South Main Travel Guide
Houston
Visit South Main
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
฿402
per adult
80% of travellers recommend
Houston: Space Center Houston Admission Ticket
฿1,002
per adult
92% of travellers recommend
Houston: Holocaust Museum Houston Entry Ticket
฿736
per adult
90% of travellers recommend
Houston's Official City & Mural Tour!
฿1,504
per adult
88% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
฿3,647
per adult
92% of travellers recommend
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
8686 Kirby Drive Houston TX
The price is ฿3,087 per night from 2 Aug to 3 Aug
฿3,087
฿3,612 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
7/10 Good! (1,359 reviews)
"the rooms looked very old and smelled of smoke, the ceiling in the bathroom leaked, and it looks molded, there was mildew on the windows, there were roaches in the first room they had us in. The flooring was stained and disgusting, there is also an old motel part in the back that looks like it has ..."
Reviewed on 20 Jul 2026
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
The price is ฿3,665 per night from 16 Aug to 17 Aug
฿3,665
฿4,327 total
16 Aug - 17 Aug
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...
8.4/10 Very good! (2,038 reviews)
"Clean room, friendly staff, great location"
Reviewed on 20 Jul 2026
Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Fully refundableReserve now, pay when you stay
The price is ฿3,904 per night from 22 Jul to 23 Jul
฿3,904
฿4,568 total
22 Jul - 23 Jul
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
The price is ฿4,296 per night from 31 Jul to 1 Aug
฿4,296
฿5,062 total
31 Jul - 1 Aug
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
8.4/10 Very good! (4,290 reviews)
"The parking situation needs work. You have to pay to park your vehicle in their garage."
Reviewed on 20 Jul 2026
Marriott Marquis Houston
1777 Walker Street Houston TX
The price is ฿9,382 per night from 30 Jul to 31 Jul
฿9,382
฿11,949 total
30 Jul - 31 Jul
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 4 restaurants. Our guests praise the pool and the helpful staff in their reviews. ...
9/10 Wonderful! (1,168 reviews)
"The view was amazing. The pool was nice and cute. The room was clean and small for the price."
Reviewed on 20 Jul 2026
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
The price is ฿5,538 per night from 25 Jul to 26 Jul
฿5,538
฿6,479 total
25 Jul - 26 Jul
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy a full-service spa, 2 bars/lounges and a rooftop terrace. Our guests praise the pool and the helpful staff in their ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
