Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,291 reviews)
"Hotel clean and convenient "
Mitzi
The price is ฿3,284
฿3,842 total
includes taxes & fees
10 May - 11 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,003 reviews)
"Really clean and friendly staff 10/10 would definitely stay again!"
Gisselle
The price is ฿2,841
฿3,324 total
includes taxes & fees
24 May - 25 May
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Great location"
Jeremy
The price is ฿2,568
฿3,005 total
includes taxes & fees
17 May - 18 May
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is ฿2,183
฿2,554 total
includes taxes & fees
29 May - 30 May
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (855 reviews)
"Kitchen fully equipped "
Royale
The price is ฿2,113
฿2,472 total
includes taxes & fees
24 May - 25 May
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (49 reviews)
"Great place! Very clean"
Donnette
The price is ฿2,158
฿2,525 total
includes taxes & fees
10 May - 11 May
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.4 out of 10, Exceptional, (46 reviews)
"Had good snacks area"
Ashley
The price is ฿3,316
฿3,880 total
includes taxes & fees
4 May - 5 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (30 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is ฿2,633
฿3,081 total
includes taxes & fees
30 Apr - 1 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (233 reviews)
"I always go to this hotel after comparing my stay at other hotels. This hotel is perfect for solo travelers and families."
Regina
The price is ฿2,897
฿3,390 total
includes taxes & fees
18 May - 19 May
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (166 reviews)
"This was a great location from downtown. The price was fair, and the rooms were spacious and clean. Great customer service!"
Tarevea
The price is ฿2,963
฿3,570 total
includes taxes & fees
30 Apr - 1 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,201 reviews)
"Super clean and close to the AirPort "
Keiry
The price is ฿4,067
฿4,759 total
includes taxes & fees
1 May - 2 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,855 reviews)
"Very nice and clean and the staff was very friendly."
Lynnette
The price is ฿3,480
฿4,093 total
includes taxes & fees
25 May - 26 May
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (780 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
David
The price is ฿2,597
฿2,935 total
includes taxes & fees
13 May - 14 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Everything was perfect and good and very clean"
Russell
The price is ฿2,679
฿3,134 total
includes taxes & fees
18 May - 19 May
Crystal Inn - NorthWest - 290
Crystal Inn - NorthWest - 29024.8 km from South Main
9.8 out of 10, Exceptional, (52 reviews)
"The best hotel I’ve been in excellent rooms perfect customer service rooms are phenomenal"
Michael
The price is ฿3,364
฿3,869 total
includes taxes & fees
30 Apr - 1 May
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Clean, friendly people, perfect "
Luis
The price is ฿2,991
฿3,499 total
includes taxes & fees
13 May - 14 May
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,727 reviews)
"Ideal hotel close to the airport. Good size rooms, comfy and decent breakfast selection "
Paul
The price is ฿3,482
฿4,074 total
includes taxes & fees
9 May - 10 May
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Magnolia Hotel Houston, A Tribute Portfolio HotelHouston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,496 reviews)
"Great location, great hotel and staff. Will stay here again. "
larry
The price is ฿4,909
฿5,844 total
includes taxes & fees
10 May - 11 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,896 reviews)
"easy to get to airport and staff was friendly and very helpful!"
Kendra
The price is ฿3,014
฿3,526 total
includes taxes & fees
3 May - 4 May
Moxy Houston Downtown
Moxy Houston DowntownDowntown Houston, 11.2 km from South Main
8.6 out of 10, Excellent, (913 reviews)
"Great location wonderful staff"
lakira
The price is ฿4,118
฿4,894 total
includes taxes & fees
21 May - 22 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,003 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 855 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,291 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,003 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
8/10 Good
