Search Hotels in South Main, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Main hotels
1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,015 reviews)
"Clean rooms and staff is great."
Tamy
The price is ฿3,006
฿3,517 total
includes taxes & fees
23 Nov - 24 Nov
2. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,490 reviews)
"Great stay!!"
Matthew
The price is ฿4,135
฿4,838 total
includes taxes & fees
6 Nov - 7 Nov
3. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"We had a excellent stay"
Jasmine
The price is ฿2,164
฿2,532 total
includes taxes & fees
22 Nov - 23 Nov
4. Wingate Houston near Reliant Park/Medical Center
Wingate Houston near Reliant Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Great place"
Crystal
The price is ฿3,003
฿3,513 total
includes taxes & fees
22 Nov - 23 Nov
5. 3 BR Condo near Reliant/NRG Stadium
3 BR Condo near Reliant/NRG StadiumSouth Main
8.0 out of 10, Very good, (1 review)
"Checkin was unpleasant because I was given the wrong lockbox information and had trouble reaching the management company. Finally I did and after an hour I got the key. They the WiFi didn’t work and I couldn’t reach anyone - another frustrating hour wasted. The hidden router just needed to be plugged in. The place itself was very comfortable and very convenient for the Reliant Stadium."
Jeffrey
The price is ฿3,815
฿12,556 total
includes taxes & fees
29 Nov - 30 Nov
6. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (901 reviews)
"Amazing friendly staff."
Olga
The price is ฿2,632
฿3,079 total
includes taxes & fees
2 Nov - 3 Nov
7. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,001 reviews)
"Great stay."
Francisco
The price is ฿4,690
฿5,514 total
includes taxes & fees
2 Nov - 3 Nov
8. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,711 reviews)
"Excellent place to stay while visiting family in Houston."
Christina
The price is ฿4,855
฿5,711 total
includes taxes & fees
25 Nov - 26 Nov
9. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,273 reviews)
"Nice place to stay, very clean"
Chafae
The price is ฿4,670
฿5,493 total
includes taxes & fees
7 Nov - 8 Nov
10. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Excellent service and location. TV’s need upgrading."
Asif
The price is ฿3,158
฿3,734 total
includes taxes & fees
23 Nov - 24 Nov
11. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,589 reviews)
"clean hotel, very nice I enjoyed my stay!"
aundrea
The price is ฿2,374
฿2,946 total
includes taxes & fees
10 Nov - 11 Nov
12. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,804 reviews)
"Very nice hotel super clean good location"
Brooke
The price is ฿4,952
฿5,813 total
includes taxes & fees
22 Nov - 23 Nov
13. InterContinental Houston by IHG
InterContinental Houston by IHGTexas Medical Center, 4.1 km from South Main
9.4 out of 10, Exceptional, (1,005 reviews)
"Great stay!"
Luke
The price is ฿5,365
฿6,951 total
includes taxes & fees
29 Nov - 30 Nov
14. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.6 out of 10, Excellent, (2,229 reviews)
"The bar/restaurant and staff was excellent."
Stephen
The price is ฿2,593
฿3,073 total
includes taxes & fees
29 Nov - 30 Nov
15. Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,077 reviews)
"Loved our stay here, will definitely be staying here again."
Franchansca
The price is ฿3,569
฿4,176 total
includes taxes & fees
8 Nov - 9 Nov
16. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (482 reviews)
"Happy to stayed there!"
AYTUNC
The price is ฿2,733
฿3,198 total
includes taxes & fees
2 Nov - 3 Nov
17. DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria8.9 km from South Main
8.4 out of 10, Very good, (4,664 reviews)
"Excellent service and nice rooms"
Jennifer
The price is ฿3,786
฿4,461 total
includes taxes & fees
27 Nov - 28 Nov
18. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,670 reviews)
"Great place to stay"
Katrina
The price is ฿4,560
฿5,358 total
includes taxes & fees
22 Nov - 23 Nov
19. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,028 reviews)
"Rooms were spacious and squeaky clean. Staff were so friendly and helpful. Hotel is close to a lot of places to eat and things to do. I absolutely loved my stay and will be staying here again in the future!"
Jakourtney
The price is ฿4,116
฿4,816 total
includes taxes & fees
22 Nov - 23 Nov
20. The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,387 reviews)
"Very nice place, great breakfast"
artur
The price is ฿4,352
฿5,092 total
includes taxes & fees
25 Nov - 26 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,015 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 901 reviews | View | ||||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,490 reviews | View | ||||||
 Wingate Houston near Reliant Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Heritage Place Houston Brookhollow
10/10 Excellent
