Search Hotels in South Main, Houston

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
28 Dec - 29 Dec
Tomorrow
29 Dec - 30 Dec
Next weekend
2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1002)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is ฿2,758
฿3,227 total
includes taxes & fees
22 Jan - 23 Jan 2026
Comfort Suites Houston near Medical Center- NRG Stadium
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (824)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is ฿2,172
฿2,542 total
includes taxes & fees
1 Jan - 2 Jan 2026
Candlewood Suites Houston Medical Center by IHG
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1004)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is ฿1,705
฿1,995 total
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn & Suites NRG Park - Medical Center
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (992)
"Easy access to stadium "
United States
Richard
The price is ฿2,141
฿2,505 total
includes taxes & fees
29 Dec - 30 Dec
Wingate Houston near NRG Park/Medical Center
Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1199)
"This place is great if you want an overnight stay for a Texans game."
United States
Jeremy
The price is ฿2,762
฿3,232 total
includes taxes & fees
29 Dec - 30 Dec
Wyndham Houston near NRG Park/Medical Center
Lobby sitting area
Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1002)
"Nice Rooms, Good atmosphere"
United States
SARGENT
The price is ฿2,453
฿2,870 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Houston West at Clay Road
Coffee service
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.8 km from South Main
9.0 out of 10, Wonderful, (968)
"Friendly staff and clean room"
United States
Doyoung
The price is ฿2,458
฿2,876 total
includes taxes & fees
31 Dec - 1 Jan 2026
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
Full-sized fridge, microwave, oven, stovetop
WoodSpring Suites Houston Northwest

WoodSpring Suites Houston Northwest

WoodSpring Suites Houston Northwest
2.5 star property
23.8 km from South Main
7.6 out of 10, Good, (510)
"Easy check in"
United States
Bryant
The price is ฿1,893
฿2,177 total
includes taxes & fees
29 Dec - 30 Dec
WoodSpring Suites Houston Northwest
Exterior
Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.3 km from South Main
8.8 out of 10, Excellent, (660)
"Great staff, Clean room. "
United States
Corliss
The price is ฿2,210
฿2,605 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites Houston I-10 West Park Row
Front of property – evening/night
Moxy Houston Downtown

Moxy Houston Downtown

Moxy Houston Downtown
3.0 star property
Downtown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (678)
"Great hotel "
United States
Norma
The price is ฿3,041
฿3,631 total
includes taxes & fees
1 Jan - 2 Jan 2026
Moxy Houston Downtown
Room, Multiple Beds, Non Smoking | Pillow-top beds, desk, iron/ironing board, free WiFi
Baymont by Wyndham Houston Hobby Airport

Baymont by Wyndham Houston Hobby Airport

Baymont by Wyndham Houston Hobby Airport
2.5 star property
18.5 km from South Main
8.6 out of 10, Excellent, (877)
"Yes they were really awesome and great staff "
United States
Jorge A
The price is ฿1,899
฿2,234 total
includes taxes & fees
5 Jan - 6 Jan 2026
Baymont by Wyndham Houston Hobby Airport
View from property
Fairfield Inn & Suites Houston Intercontinental Airport

Fairfield Inn & Suites Houston Intercontinental Airport

Fairfield Inn & Suites Houston Intercontinental Airport
3.0 star property
30.5 km from South Main
8.6 out of 10, Excellent, (1001)
"Great place, nice room"
United States
Lester
The price is ฿2,334
฿2,781 total
includes taxes & fees
31 Dec - 1 Jan 2026
Fairfield Inn & Suites Houston Intercontinental Airport
Lobby
Embassy Suites Houston Downtown

Embassy Suites Houston Downtown

Embassy Suites Houston Downtown
3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1006)
"Great breakfast!,made fresh if front of you if requested! Great overall staff as well."
United States
Loren
The price is ฿4,301
฿5,032 total
includes taxes & fees
5 Jan - 6 Jan 2026
Embassy Suites Houston Downtown
Reception
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
2.5 star property
19.4 km from South Main
8.2 out of 10, Very good, (900)
"Employees were very gentle and friendly, food was always warm, very clean spaces."
United States
Melvin
The price is ฿2,203
฿2,578 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
Outdoor pool, pool loungers
Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
10.2 km from South Main
9.2 out of 10, Wonderful, (1073)
"Great place! Awesome location. "
United States
Irena Ademaj
The price is ฿3,476
฿4,067 total
includes taxes & fees
29 Dec - 30 Dec
Best Western Plus Downtown Inn & Suites
Lobby
Comfort Suites Westchase Houston Energy Corridor

Comfort Suites Westchase Houston Energy Corridor

Comfort Suites Westchase Houston Energy Corridor
2.5 star property
Westchase, 16.3 km from South Main
8.4 out of 10, Very good, (677)
"Very comfortable stay, nice rooms and incredible staff "
United States
Austin
The price is ฿1,745
฿2,352 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Westchase Houston Energy Corridor
Exterior
La Quinta Inn & Suites by Wyndham Richmond-Sugarland

La Quinta Inn & Suites by Wyndham Richmond-Sugarland

La Quinta Inn & Suites by Wyndham Richmond-Sugarland
3.0 star property
30.1 km from South Main
8.6 out of 10, Excellent, (1007)
"Great place"
United States
Andre
The price is ฿2,421
฿2,784 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
Cocktail bar
Le Meridien Houston Downtown

Le Meridien Houston Downtown

Le Meridien Houston Downtown
4.0 star property
Houston Central Business District, 10.7 km from South Main
8.8 out of 10, Excellent, (1008)
"Very nice staff, felt safe, very clean and at a nice location. "
United States
Shalita
The price is ฿4,196
฿4,909 total
includes taxes & fees
30 Dec - 31 Dec
Le Meridien Houston Downtown
Restaurant
Home2 Suites by Hilton Houston Westchase

Home2 Suites by Hilton Houston Westchase

Home2 Suites by Hilton Houston Westchase
3.0 star property
Westchase, 16.1 km from South Main
8.8 out of 10, Excellent, (891)
"Had a great stay. Staff was welcoming, the room was clean and breakfast was good. In a great location, definitely would stay here again! "
United States
Joy
The price is ฿2,730
฿3,242 total
includes taxes & fees
10 Jan - 11 Jan 2026
Home2 Suites by Hilton Houston Westchase
Lobby
Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
30 km from South Main
8.4 out of 10, Very good, (1007)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
United States
Debra
The price is ฿2,607
฿3,050 total
includes taxes & fees
1 Jan - 2 Jan 2026
Four Points by Sheraton Houston Intercontinental Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green showing city views, modern architecture and a high-rise building

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Menil Collection featuring interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

10/10 Excellent
"Everything "
christye 1-night trip
Posted 19 hours ago
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.