Search Hotels in South Main, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,291 reviews)
"Hotel clean and convenient "
Mitzi
The price is ฿3,278
฿3,835 total
includes taxes & fees
17 May - 18 May
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is ฿2,201
฿2,575 total
includes taxes & fees
30 May - 31 May
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Great location"
Jeremy
The price is ฿2,590
฿3,030 total
includes taxes & fees
17 May - 18 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,003 reviews)
"Really clean and friendly staff 10/10 would definitely stay again!"
Gisselle
The price is ฿2,849
฿3,333 total
includes taxes & fees
31 May - 1 Jun
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (857 reviews)
"Kitchen fully equipped "
Royale
The price is ฿2,131
฿2,493 total
includes taxes & fees
24 May - 25 May
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Everything was great parking food clean everything was awesome"
Sergio
The price is ฿3,093
฿3,557 total
includes taxes & fees
3 May - 4 May
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,849 reviews)
"Excellent breakfast and property was very clean!"
Brett
The price is ฿3,763
฿4,328 total
includes taxes & fees
3 May - 4 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,201 reviews)
"Super clean and close to the AirPort "
Keiry
The price is ฿4,101
฿4,798 total
includes taxes & fees
1 May - 2 May
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,159 reviews)
"Friendly staffs clean room good location "
Adeyemi
The price is ฿2,736
฿3,146 total
includes taxes & fees
28 May - 29 May
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (51 reviews)
"Great place! Very clean"
Donnette
The price is ฿2,176
฿2,546 total
includes taxes & fees
10 May - 11 May
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (780 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
David
The price is ฿2,619
฿2,960 total
includes taxes & fees
17 May - 18 May
Hampton Inn Houston-Pearland
Hampton Inn Houston-Pearland15.7 km from South Main
8.6 out of 10, Excellent, (611 reviews)
"Nice and decent property. "
Sylvia
The price is ฿3,632
฿4,134 total
includes taxes & fees
13 May - 14 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (233 reviews)
"Great breakfast and good A/C. No swimming pool.
"
Summer
The price is ฿3,098
฿3,625 total
includes taxes & fees
22 May - 23 May
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (686 reviews)
"Amazing staff and breakfast"
Tiffany
The price is ฿1,770
฿2,036 total
includes taxes & fees
6 May - 7 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (30 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is ฿2,633
฿3,081 total
includes taxes & fees
5 May - 6 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,900 reviews)
"easy to get to airport and staff was friendly and very helpful!"
Kendra
The price is ฿2,832
฿3,314 total
includes taxes & fees
3 May - 4 May
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,728 reviews)
"Ideal hotel close to the airport. Good size rooms, comfy and decent breakfast selection "
Paul
The price is ฿3,901
฿4,564 total
includes taxes & fees
15 May - 16 May
Embassy Suites by Hilton Houston Energy Corridor
Embassy Suites by Hilton Houston Energy Corridor21 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean room,omg breakfast was so good and happy hour was great. Front desk staff was great "
Tamashia
The price is ฿5,023
฿5,877 total
includes taxes & fees
8 May - 9 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Breakfast was great"
Tracy
The price is ฿2,648
฿3,098 total
includes taxes & fees
24 May - 25 May
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (865 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
Travis
The price is ฿3,520
฿4,118 total
includes taxes & fees
24 May - 25 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,003 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 857 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,291 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
10/10 Excellent
