South Main Travel Guide
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
MD Anderson Cancer Center
If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art galleries and great live music in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.
Things to do
Space Center Houston Admission Ticket
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Space Center Houston Admission Ticket
Houston: Museum of Natural Science General Admission Ticket
NASA's Space Center & Official Houston City Tour with tickets
Houston: Holocaust Museum Houston Entry Ticket
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
A/c did not work in the room
Reviewed on 27 Apr 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The lobby smelt like weed and there was one person working the desk during check in with a long line of people waiting. The breakfast wasn't free like we were told. The Valet regularly blocked out ability to get into the parking garage.
Reviewed on 28 Apr 2026
Club Quarters Hotel Downtown, Houston
Club Quarters is hands down the best
Reviewed on 28 Apr 2026
Blossom Hotel Houston, Curio Collection by Hilton
Advertising says THREE restaurants, there is only ONE. The original restaurant closed after 3 months. Coffee bar in the lobby has minimal options.
Reviewed on 28 Apr 2026
The Whitehall Houston
We stayed a total of 4 nights. Was told we’d get house keeping
Reviewed on 28 Apr 2026
Hilton Houston Plaza/Medical Center
Good stay for price and location. The room was fairly clean except shower, which was an easy fix. AC worked well and was turned on for check in. The staff were excellent.
Reviewed on 25 Apr 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Arena, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Continental Club or Children's Museum of Houston and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travellers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
