South Main Travel Guide

Houston

A city skyline with modern buildings and a park with a lake.
A modern urban street with a metro train, buildings, and a clear blue sky.

Things to do


Top hotels in South Main

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

3.5 out of 5
8686 Kirby Drive Houston TX
The price is ฿2,558 per night from 1 Sept to 2 Sept
฿2,558
฿2,993 total
1 Sept - 2 Sept
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, a 24-hour fitness centre and a 24-hour front desk. Our guests praise the helpful staff and ...
Wyndham Houston near NRG Park/Medical Center
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street Houston TX
The price is ฿3,925 per night from 5 Aug to 6 Aug
฿3,925
฿4,592 total
5 Aug - 6 Aug
includes taxes & fees
Stay at this business-friendly hotel in Houston. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the restaurant and the helpful staff ...
8.6/10 Excellent! (4,406 reviews)
"great locaton for us and good value."

Reviewed on 1 Aug 2026

Club Quarters Hotel Downtown, Houston
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd Houston TX
The price is ฿4,683 per night from 11 Aug to 12 Aug
฿4,683
฿5,517 total
11 Aug - 12 Aug
includes taxes & fees
Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge) and a free local area shuttle. Our guests praise the helpful staff and the clean ...
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4 out of 5
7118 Bertner Ave Houston TX
The price is ฿6,433 per night from 15 Aug to 16 Aug
฿6,433
฿7,527 total
15 Aug - 16 Aug
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy a full-service spa, 2 bars/lounges and a rooftop terrace. Our guests praise the pool and the helpful staff in their ...
Blossom Hotel Houston, Curio Collection by Hilton
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 out of 5
6633 Travis St Houston TX
The price is ฿5,283 per night from 11 Aug to 12 Aug
฿5,283
฿6,220 total
11 Aug - 12 Aug
includes taxes & fees
Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in their reviews. ...
Hilton Houston Plaza/Medical Center
Marriott Marquis Houston

Marriott Marquis Houston

4 out of 5
1777 Walker Street Houston TX
The price is ฿8,660 per night from 13 Aug to 14 Aug
฿8,660
฿11,090 total
13 Aug - 14 Aug
includes taxes & fees
Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 4 restaurants. Our guests praise the pool and the helpful staff in their reviews. ...
9/10 Wonderful! (1,203 reviews)
"Muy decepcionada. Esperaba mucho más de un hotel que se vende como de lujo. Todo es exageradamente caro y constantemente intentan venderte servicios adicionales. La comida fue una gran decepción. El desayuno no está a la altura del precio del hotel y las opciones para comer son muy limitadas. Uno ..."

Reviewed on 31 Jul 2026

Marriott Marquis Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.



South Main Travel Guide