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Mississippi County Accommodation: Most Popular Cities to Stay

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HotelsHotels

Charleston

Charleston
A tree-lined landscape with a river and fields.
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East Prairie

East Prairie

Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Mississippi County hotels

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1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (441 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is ฿2,232
฿2,499 total
includes taxes & fees
17 Oct - 18 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (677 reviews)
"This place was so dirty and in much need of repair. We got in late or there’s no way we would have stayed here. They tried to use perfume to cover up the smell but it made it so much worse!"
United States
William
The price is ฿1,997
฿2,237 total
includes taxes & fees
20 Oct - 21 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is ฿2,220
฿2,485 total
includes taxes & fees
16 Oct - 17 Oct
Eagle Inn Charleston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is ฿2,316
฿2,570 total
includes taxes & fees
2 Nov - 3 Nov
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Very friendly & professional staff. Trustworthy room attendants, with attention to details. Beds comfortable. Everyone enjoyed the morning breakfast, with a good menu. Cocktail hour widely attended. Would definitely stay here again!"
Sherri 2-night trip
Posted 2 hours ago
Drury Inn & Suites Sikeston, MO