Find hotels in East Prairie, MO from ฿2,018

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Our top choices for East Prairie hotels

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (53 reviews)
"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! "
United States
Sue
The price is ฿2,136
฿2,440 total
includes taxes & fees
3 Apr - 4 Apr
Super 8 By Wyndham Marston

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (557 reviews)
"Very clean nice staff and well run "
United States
zach
The price is ฿2,077
฿2,466 total
includes taxes & fees
28 Mar - 29 Mar
Country Hearth Inn & Suites Union City

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"Very nice for overnight stay"
United States
Scott
The price is ฿3,099
฿3,563 total
includes taxes & fees
5 Apr - 6 Apr
Drury Inn & Suites Sikeston, MO

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (410 reviews)
"Clean "
United States
Chris
The price is ฿1,899
฿2,107 total
includes taxes & fees
29 Mar - 30 Mar
The Riverstone Hotel Charleston-Sikeston

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (368 reviews)
"Great stay. "
United States
Paul
The price is ฿2,631
฿3,124 total
includes taxes & fees
5 Apr - 6 Apr
Sleep Inn at Discovery Park of America

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (65 reviews)
"Nice quiet hotel "
United States
Steven
The price is ฿3,330
฿3,770 total
includes taxes & fees
5 Apr - 6 Apr
Fairfield Inn & Suites by Marriott Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (754 reviews)
"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"
United States
Mark
The price is ฿2,159
฿2,461 total
includes taxes & fees
29 Mar - 30 Mar
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (513 reviews)
"Great stay"
United States
grant
The price is ฿3,254
฿3,685 total
includes taxes & fees
12 Apr - 13 Apr
Hampton Inn Sikeston

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (500 reviews)
"Overall, a decent stay. No fancy bells or whistles, exactly what was advertised and delivered. Only issue of note was that the room smelled of body odder when we stayed. "
United States
John
The price is ฿2,605
฿3,093 total
includes taxes & fees
29 Mar - 30 Mar
Quality Inn Union City US 51

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (475 reviews)
"Ok one night stay."
United States
David
The price is ฿2,299
฿2,638 total
includes taxes & fees
29 Mar - 30 Mar
Reelfoot Lake Inn

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (754 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is ฿1,869
฿2,018 total
includes taxes & fees
29 Mar - 30 Mar
New Orleans Inn Portageville

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (627 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is ฿2,047
฿2,272 total
includes taxes & fees
28 Mar - 29 Mar
Super 8 by Wyndham Charleston/Sikeston East MO

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,000 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is ฿3,054
฿3,481 total
includes taxes & fees
2 Apr - 3 Apr
Best Western Plus Sikeston I-55

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (450 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is ฿3,066
฿3,472 total
includes taxes & fees
12 Apr - 13 Apr
Holiday Inn Express & Suites Sikeston Southwest by IHG

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (15 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is ฿3,755
฿4,252 total
includes taxes & fees
5 Apr - 6 Apr
TownePlace Suites by Marriott Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is ฿2,242
฿2,555 total
includes taxes & fees
29 Mar - 30 Mar
Days Inn and Suites by Wyndham Sikeston

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is ฿2,519
฿2,795 total
includes taxes & fees
28 Mar - 29 Mar
Quality Inn Cairo I-57

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (175 reviews)
"Spotless , friendly staff."
United States
Gail
The price is ฿4,542
฿5,393 total
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn Union City

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105 reviews)
"The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected."
United States
Britani
The price is ฿2,089
฿2,318 total
includes taxes & fees
28 Mar - 29 Mar
Eagle Inn Charleston

Travel Inn

Travel Inn
2.5 star property
Marston
6.0 out of 10, (119 reviews)
"Had a great time loved it "
United States
Shyianne
The price is ฿1,813
฿2,070 total
includes taxes & fees
30 Mar - 31 Mar
Travel Inn
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.