Charleston Holiday Rentals, Missouri: Private House Rentals

A sunset over a calm lake with tall trees reflected in the water.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Charleston

Pet friendly

Apartment

Pool

Family friendly

Waterpark

Condo

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Charleston hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

฿1,997

฿2,237 total

includes taxes & fees

11 Nov - 12 Nov

A building with a fountain and flower beds in front.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

฿2,232

฿2,499 total

includes taxes & fees

16 Oct - 17 Oct

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

3. Eagle Inn Charleston

Charleston

Jackson

฿2,215

฿2,480 total

includes taxes & fees

15 Oct - 16 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

4. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

฿3,155

฿3,627 total

includes taxes & fees

11 Nov - 12 Nov

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

5. Hampton Inn Sikeston

Sikeston

Lori

฿3,527

฿4,011 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

6. Best Western Plus Sikeston I-55

Sikeston

฿2,798

฿3,189 total

includes taxes & fees

15 Oct - 16 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A buffet with various food items, including omelets and baked goods, served in metal containers.

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

฿3,128

฿3,557 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

฿3,397

฿3,863 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

฿2,333

฿2,659 total

includes taxes & fees

10 Nov - 11 Nov

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

10. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

฿3,659

฿4,161 total

includes taxes & fees

22 Oct - 23 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

11. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

฿2,225

฿2,537 total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A motel with a covered entrance, multiple rooms, and a parking lot.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

12. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

฿1,917

฿2,185 total

includes taxes & fees

9 Nov - 10 Nov

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

13. Comfort Inn & Suites Sikeston I-55

Sikeston

Kathryn

฿2,669

฿3,042 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

14. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Darnetta

฿3,356

฿3,786 total

includes taxes & fees

26 Oct - 27 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

15. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Troy

฿2,416

฿2,726 total

includes taxes & fees

26 Oct - 27 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

16. The Riverview

Cape Girardeau

Alyssa

฿3,837

฿4,328 total

includes taxes & fees

15 Oct - 16 Oct

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

17. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Rebecca

฿3,390

฿3,859 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

18. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

฿3,395

฿3,830 total

includes taxes & fees

12 Nov - 13 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

19. Country Yard Inn and Suite

Sikeston

William

฿1,961

฿2,333 total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

20. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

฿3,021

฿3,408 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, cathedral and more.

See all hotels in Charleston

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"They serve an amazing happy hour and breakfast with à large selection of food. Very nice and comfortable room"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"We have stayed here a number of times over 20 years. It’s always clean and well maintained. Breakfast is very good. Staff is always friendly and helpful."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Excellent Stay!!!very very comfortable room and very friendly staff…I wish they had a swimming pool and workout room but,it was all around,GREAT!!!!!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"The food was excellent"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Everything perfect. Drury Inns sweat the details."

The Riverview

10/10 Excellent

"."

Hampton Inn Cape Girardeau I 55 East

8/10 Good

"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Very nice! Bed was comfortable and room had a very large bathroom and shower. Towels were thick and fluffy. Enjoyed having a bar downstairs with a fun friendly staff. Will stay there again when I’m coming through."

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

฿1,917

฿2,185 total

9 Nov - 10 Nov

includes taxes & fees

7/10 Good! (687 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

฿2,225

฿2,537 total

9 Nov - 10 Nov

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

฿2,416

฿2,726 total

26 Oct - 27 Oct

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

฿2,798

฿3,189 total

15 Oct - 16 Oct

includes taxes & fees

8.4/10 Very good! (1,000 reviews)

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

฿2,758

฿3,296 total

25 Oct - 26 Oct

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

฿3,390

฿3,859 total

25 Oct - 26 Oct

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

Frequently asked questions

Where is the best place for a stay in Charleston?

Based on our traveller data, The Riverstone Hotel Charleston-Sikeston is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good options for your trip include Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See all available top hotels, or vacation rentals in Charleston.

If I need to cancel my hotel reservation in Charleston, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Charleston.

What is the top LGBTQ-friendly accommodation in Charleston?

The Riverstone Hotel Charleston-Sikeston is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. See all available hotels listed as LGBTQ-friendly in Charleston.

What's the best dog-friendly accommodation option in Charleston?

The Riverstone Hotel Charleston-Sikeston is a top dog-friendly hotel, and offers a seasonal outdoor pool and laundry facilities for its human guests. Other good options to stay with your pet include Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See more pet-friendly hotel accommodations in Charleston.

How is it staying in Charleston?

Visitors to Charleston will definitely enjoy the restaurants. Tourists can also enjoy the city's entertainment choices, theatres and churches. In Charleston, there are 3 hotels and other accommodation options to choose from. Find out more about Charleston.

What should I do while I'm visiting Charleston?

The picturesque setting of Mississippi River and Ohio River exemplify the area's natural beauty. You'll also find Ballard Wildlife Management Area and Columbus-Belmont State Park in the area. Take a look at what more there is to see and do in Expedia's Charleston guide.

What's the seasonal weather like in Charleston?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Charleston is 1509 mm.

Explore a world of travel with Expedia

More ways to book

Book Hotels in Charleston on Expedia.com

Find hotels in Charleston, MO from ฿1,926

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Charleston

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Charleston hotels

1. Super 8 by Wyndham Charleston/Sikeston East MO

2. The Riverstone Hotel Charleston-Sikeston

3. Eagle Inn Charleston

4. Drury Inn & Suites Sikeston, MO

5. Hampton Inn Sikeston

6. Best Western Plus Sikeston I-55

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

8. Fairfield Inn & Suites by Marriott Sikeston

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. TownePlace Suites by Marriott Sikeston

11. Days Inn and Suites by Wyndham Sikeston

12. Super 8 by Wyndham Sikeston/Miner Area

13. Comfort Inn & Suites Sikeston I-55

14. Drury Plaza Hotel Cape Girardeau Conference Center

15. Pear Tree Inn Cape Girardeau West

16. The Riverview

17. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

18. Fairfield Inn & Suites by Marriott Cape Girardeau

19. Country Yard Inn and Suite

20. Drury Inn & Suites Cape Girardeau

Learn more about Charleston

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Super 8 by Wyndham Sikeston/Miner Area

Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Sikeston, MO

The Riverview

Hampton Inn Cape Girardeau I 55 East

Courtyard by Marriott Cape Girardeau Downtown

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Best Western Plus Sikeston I-55

Candlewood Suites Cape Girardeau by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app