Find hotels in Charleston, MO from ฿1,978

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24 Dec - 25 Dec
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25 Dec - 26 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Charleston hotels

Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
"Staff was great! Room was nice. "
United States
Lana
The price is ฿1,932
฿2,144 total
includes taxes & fees
19 Jan - 20 Jan 2026
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The on-site health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.
"Middle of nowhere hotel was ok"
United States
David
The price is ฿1,882
฿2,088 total
includes taxes & fees
25 Dec - 26 Dec
Eagle Inn Charleston
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
This centrally located hotel offers convenient access to restaurants and shopping. Take advantage of the indoor pool and fitness centre after exploring nearby Cape Splash Family Aquatic Centre. Free breakfast, WiFi, and parking enhance your stay with attentive staff ready to assist.
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ฿2,832
฿3,195 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness centre. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is ฿3,035
฿3,437 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness centre keeps your routine intact while complimentary breakfast energises your day exploring nearby Central Park and Sikeston Depot Museum.
"Everything was clean, staff was friendly "
United States
Matthew
The price is ฿2,333
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Sikeston
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1009)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ฿2,353
฿2,682 total
includes taxes & fees
29 Dec - 30 Dec
Best Western Plus Sikeston
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
Wake up to Mississippi River views at this city centre hotel, steps from Riverfront Park and Shawnee National Forest. After exploring, return to The Bistro for American cuisine or unwind at the bar. The 24-hour fitness centre and in-room refrigerators enhance your stay.
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ฿3,888
฿4,406 total
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard by Marriott Cape Girardeau Downtown
Basic Double Room | Free WiFi
La Center Motel

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
Just 15 minutes from Ohio River Valley, this La Centre hotel offers convenient amenities including complimentary WiFi and parking. Easy access to Paducah and Barkley Regional Airport makes exploration effortless.
"Quiet and convenient."
United States
Alma
La Center Motel
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1004)
This peaceful hotel offers a quiet atmosphere just minutes from Shawnee National Forest and Cape Splash Family Aquatic Centre. Nearby restaurants and stores enhance convenience while helpful staff ensure a comfortable stay with free WiFi and daily housekeeping.
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ฿2,177
฿2,456 total
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
Walking distance to restaurants and shops, this peaceful hotel offers complimentary breakfast, WiFi, and parking. Swim year-round in the indoor pool or unwind in the hot tub after exploring nearby attractions like Cape Splash Family Aquatic Centre.
"Very friendly staff and great breakfast"
United States
Ray
The price is ฿2,799
฿3,158 total
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Cape Girardeau
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is ฿3,764
฿9,020 total
includes taxes & fees
27 Dec - 28 Dec
Quiet Country Stay: Modern Home Near Paducah
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness centre. Near Central Park and Sikeston Depot Museum, travellers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.
"Room was clean, breakfast was very good. "
United States
Connie
The price is ฿2,750
฿3,134 total
includes taxes & fees
22 Jan - 23 Jan 2026
Comfort Inn & Suites Sikeston I-55
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
Discover comfort at this Sikeston hotel with an indoor pool and fitness centre. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ฿3,266
฿3,698 total
includes taxes & fees
18 Jan - 19 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Courtyard
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
Located near Shawnee National Forest and Mississippi River, this hotel offers complimentary breakfast, WiFi and parking. Unwind in the indoor pool, utilise the fitness centre or relax on the terrace. Clean rooms feature refrigerators and microwaves.
"Excellent stay"
United States
Christina
The price is ฿3,163
฿3,568 total
includes taxes & fees
31 Dec - 1 Jan 2026
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
Explore Shawnee National Forest from this Cape Girardeau hotel offering complimentary breakfast, WiFi, and parking. Enjoy the indoor pool and hot tub after a day out, or dine at The Southerner restaurant. Each room includes handy refrigerators and microwaves.
"Great place and staff, very accommodating!"
United States
Megan
The price is ฿2,799
฿3,158 total
includes taxes & fees
29 Dec - 30 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (41)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ฿3,144
฿3,559 total
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
Start your day with complimentary breakfast at this Sikeston hotel. Enjoy free WiFi and parking while staying minutes from Central Park and the Sikeston Depot Museum. Cape Girardeau Municipal Airport is just a 29-minute drive away.
"Awesomeness "
United States
Rick
The price is ฿1,848
฿2,106 total
includes taxes & fees
13 Jan - 14 Jan 2026
Super 8 by Wyndham Sikeston/Miner Area
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (476)
Located near Riverfront Park and Isle Casino, this business-friendly hotel offers exciting gaming, 2 restaurants including Beacon 53 for American cuisine, plus free WiFi and parking for convenient exploration of Cape Girardeau.
"The room was clean and the mattress was extremely comfortable "
United States
Stacy
The price is ฿2,996
฿3,379 total
includes taxes & fees
29 Dec - 30 Dec
The Riverview
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is ฿2,799
฿3,218 total
includes taxes & fees
28 Dec - 29 Dec
Drury Inn & Suites Sikeston, MO
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
This Sikeston motel offers a convenient base for exploring nearby Central Park and Sikeston Depot Museum. Enjoy thoughtful amenities like free WiFi and parking alongside 24-hour front desk service for assistance anytime.
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is ฿1,662
฿1,978 total
includes taxes & fees
25 Dec - 26 Dec
Country Yard Inn and Suite
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, cathedral and more.

See all hotels in Charleston
Cypress Trees on the Horizon. A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.

Top Charleston Hotel Reviews

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent
"Very clean environment. Staff is very nice and friendly. Will not mind staying here again in future. "
Rahveen 2-night trip
Posted 10 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

More cheap stays in Charleston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is ฿1,957 per night from 20 Jan to 21 Jan
฿1,957
฿2,230 total
20 Jan - 21 Jan 2026
includes taxes & fees
7.2/10 Good! (1,000 reviews)

Frequently asked questions

Where is the best place for a stay in Charleston?
Quality Inn Charleston - Sikeston is a favourite with Expedia customers. This hotel offers free breakfast and free parking. Traveller reviews also recommend Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston as top choices for your stay. See all available top hotels, or vacation rentals in Charleston.
If I need to cancel my hotel reservation in Charleston, will I receive a refund?
Yes, most hotel bookings are fully refundable if cancelled prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Charleston.
What's the best dog-friendly accommodation option in Charleston?
Quality Inn Charleston - Sikeston is a top hotel for people travelling with their pets and offers free WiFi for its human guests. Other good options to stay with your pet include Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See more pet-friendly hotel accommodations in Charleston.
How is it staying in Charleston?
Visitors to Charleston will definitely enjoy the restaurants. Tourists can also enjoy the city's entertainment choices, theatres and churches. In Charleston, there are 3 hotels and other accommodation options to choose from. Find out more about Charleston.
What should I do while I'm visiting Charleston?
The picturesque setting of Mississippi River and Ohio River exemplify the area's natural beauty. You'll also find Central Park and Ballard Wildlife Management Area in the area. Take a look at what more there is to see and do in Expedia's Charleston guide.
What's the seasonal weather like in Charleston?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Charleston is 1509 mm.