Find hotels in Byron, MN from ฿2,342
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Our top choices for Byron hotels
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHGDowntown Rochester
8.8 out of 10, Excellent, (892)
Located within walking distance of Mayo Clinic, this hotel offers quiet rooms and convenient access to Rochester Public Library. The on-site Crave restaurant serves American cuisine, while the rooftop terrace provides a serene escape after a busy day.
"Room was clean and comfortable
Staff courteous
Comfortable beds
Great restaurant"
Matney
The price is ฿2,393
฿2,755 total
includes taxes & fees
24 Jan - 25 Jan 2026
Americas Best Value Inn & Suites Spring Valley
Americas Best Value Inn & Suites Spring ValleySpring Valley
8.2 out of 10, Very good, (434)
Enjoy free morning meals and convenient parking at this well-maintained property. Work out in the fitness centre after exploring nearby Masonic Park and Four Daughters Vineyard & Winery. Clean rooms and business-friendly amenities create a comfortable base for your stay.
"The place was very clean, very quiet and the staff was extremely helpful. We will be back"
Melissa
The price is ฿2,642
฿2,916 total
includes taxes & fees
19 Jan - 20 Jan 2026
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic SRochester
7.2 out of 10, Good, (1026)
Located within a 10-minute drive of Mayo Clinic, this Rochester hotel offers complimentary perks including daily buffet breakfast, Wi-Fi, and self parking. Guests can maintain routines at the fitness centre while enjoying clean, comfortable rooms praised by travellers.
"Staff was courteous and breakfast was well stocked."
Doug
The price is ฿2,238
฿2,576 total
includes taxes & fees
28 Dec - 29 Dec
8.0 out of 10, Very good, (419)
Just 15 minutes from Mayo Clinic, this Stewartville hotel provides complimentary breakfast, Wi-Fi and parking. Guests appreciate the clean rooms and convenient access to Maple Valley Golf & Country Club.
"Room was nicer and furnished better than most high end places I’ve stayed at. It’s a small hotel on a busy road, but comfortable bed and clean."
Robert
Holiday Inn Express Rochester South - Mayo Area by IHG
Holiday Inn Express Rochester South - Mayo Area by IHGRochester
8.8 out of 10, Excellent, (1002)
This welcoming hotel puts you just 10 minutes from Mayo Clinic. Start each morning with complimentary breakfast before unwinding in the hot tub. The fitness centre, free parking, and helpful staff ensure a comfortable, convenient visit.
"As usual Helpful and kind staff. "
Shahram
The price is ฿2,269
฿2,612 total
includes taxes & fees
1 Jan - 2 Jan 2026
9.0 out of 10, Wonderful, (1001)
Enjoy tranquility at this Rochester hotel with an indoor pool and hot tub to unwind after Mayo Clinic visits. Free WiFi, parking, and breakfast await, with Olmsted County Fairgrounds and Apache Mall nearby. Guests praise the quiet atmosphere and helpful staff.
"We had a wonderful stay!"
Sarah
The price is ฿2,501
฿2,879 total
includes taxes & fees
24 Jan - 25 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Byron attractions
Top Byron Hotel Reviews
Spark by Hilton Rochester South
10/10 Excellent
More cheap stays in Byron
Microtel Inn & Suites by Wyndham Rochester North Mayo Clinic
4210 Highway 52 North Rochester MN
The price is ฿2,034 per night from 28 Dec to 29 Dec
฿2,034
฿2,342 total
28 Dec - 29 Dec
includes taxes & fees
7.8/10 Good! (1,000 reviews)
