5 Stars Hotels in Panama City

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Check availability on Panama City 5 Star Hotels

Tonight
27 Dec - 28 Dec
Tomorrow
28 Dec - 29 Dec
Next weekend
2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

Our top choices for Panama City 5-star hotels

Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4724)
"Awesome great place to stay "
United States
Herbert
The price is ฿3,800
฿4,181 total
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Riu Plaza Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1001)
"I loved everything about my stay "
United States
Stephanie
The price is ฿6,846
฿7,530 total
includes taxes & fees
10 Jan - 11 Jan 2026
Waldorf Astoria Panama
2 restaurants, local cuisine
W Panama

W Panama

W Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1005)
"staff and food are amazing "
Canada
Judy
The price is ฿6,679
฿7,347 total
includes taxes & fees
10 Jan - 11 Jan 2026
W Panama
4 outdoor pools, free pool cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1002)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ฿10,223
฿11,245 total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (565)
"Amazing hotel , location , staff and amenities . Clean, elegant , great service. "
United States
Nicole
The price is ฿11,357
฿12,493 total
includes taxes & fees
13 Jan - 14 Jan 2026
Sofitel Legend Casco Viejo, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1000)
"Nice room! Clean. Nice balcony, "
United States
Cassandra
The price is ฿6,253
฿6,878 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hilton Panama
3 outdoor pools, pool umbrellas, pool loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very good, (1000)
"Great place and location, excellent food choices! "
United States
Francisco
The price is ฿7,082
฿7,790 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Westin Playa Bonita Panama
40-inch Smart TV with cable channels, TV
Renaissance Panama City Hotel

Renaissance Panama City Hotel

Renaissance Panama City Hotel
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (97)
"Great location and amazing staff"
United States
Aziz
The price is ฿3,600
฿3,960 total
includes taxes & fees
10 Jan - 11 Jan 2026
Renaissance Panama City Hotel
Couples treatment room(s), sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Great staff, super accommodating. Best place to stay in Panama!"
United States
Sebastian
The price is ฿6,233
฿6,857 total
includes taxes & fees
14 Jan - 15 Jan 2026
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ฿6,960
฿7,656 total
includes taxes & fees
25 Jan - 26 Jan 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
View from property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá
Outdoor pool
Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
The price is ฿3,414 per night from 12 Jan to 13 Jan
฿3,414
฿3,755 total
12 Jan - 13 Jan 2026
includes taxes & fees
8.4/10 Very Good! (2,331 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
Panoramic view at the Downtown of Panama City - Panama

Top Panama City Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"No worries. Outstanding in every aspects. Room, food, personnel, pool, location. "
siany Gordon 3-night trip
Posted 6 days ago
Hotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

10/10 Excellent
"Amazing breakfast the 1st day, ok breakfast the 2nd day. Concierge was amazing. Loved the hotel and it's smell. Absolutely recommend! Teenage kids loved it too!"
Nancy 2-night trip
Posted 11 days ago
Waldorf Astoria Panama

Frequently asked questions

What are the best 5-star hotels in Panama City?
According to Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are among the top 5-star hotels in Panama City. Providing top-quality amenities and unmatchable service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to find the best deal on a luxurious getaway.

  • Search for the lowest price per night from ฿3,755

What makes a hotel 5 stars in Panama City?
From fine dining restaurants and 24-hour gyms to swimming pools and the finest bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Hotels also have to offer remarkable guest-centric services like in-room beauty treatments, on-site laundry and dry cleaning and room service any time day or night.