A bridge over a turquoise waterfront with boats docked, surrounded by historic buildings.

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Check prices for these dates

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

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Our top choices for Santa Lucia hotels

A historic building with ornate balconies, a grand entrance, and flags of the European Union and Italy.

1. Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (709 reviews)
"We enjoyed our stay"
United States
Anna
The price is ฿2,893
฿3,298 total
includes taxes & fees
15 Nov - 16 Nov
Grande Albergo Alfeo
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.

2. Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (300 reviews)
"Staff was very friendly and helpful"
Canada
Dena
The price is ฿5,157
฿6,052 total
includes taxes & fees
6 Nov - 7 Nov
Caportigia Boutique Hotel
A modern hotel room with a flat-screen TV mounted on a dark wall, a white desk with a remote control, a bed with a black and white patterned bedspread, and a window with curtains.

3. Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (299 reviews)
"Nostos was clean and comfortable. It was well situated for city sites, tour pickup points, and public transportation. Staff was very helpful. There was no elevator (lift), but the staff carried our bags up two flights."
United States
Cosimo
The price is ฿2,063
฿2,352 total
includes taxes & fees
15 Nov - 16 Nov
Nostos rooms & Apartments
A hotel room with a large bed, a chair, a small table, and a chandelier.

4. Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (52 reviews)
"Location was very good"
United States
Jose
The price is ฿3,085
฿3,516 total
includes taxes & fees
6 Nov - 7 Nov
Hotel Palazzo Cavalieri
A balcony with wicker chairs and a glass table overlooking a marina with boats.

5. Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (45 reviews)
"Beautiful accomodation, perfect location close to restauranys and attractions, clean room/all renovated with style, friendly personnel, nice view of the port"
Canada
Martine
The price is ฿5,680
฿6,476 total
includes taxes & fees
8 Nov - 9 Nov
Fortaleza Charme House
A room with a table and chairs, a view of a harbor with boats and buildings, and a clear sky.

6. Lakkios

Lakkios
3.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (82 reviews)
"The location of this place is amazing and that balcony view iconic. Staff super helpful too."
Canada
Marsel
The price is ฿3,094
฿3,527 total
includes taxes & fees
5 Nov - 6 Nov
Lakkios
A neatly made bed with a dark quilt, white pillows, and a beige headboard. There are two bedside lamps on either side of the bed.

7. Melody rooms

Melody rooms
Santa Lucia
9.0 out of 10, Wonderful, (2 reviews)
"Custo benefícios muito bom e localização boa. Sinal do wifi fraco no quarto q estávamos e café da manha com poucas opções."
Brazil
Phillipe
The price is ฿1,317
฿1,502 total
includes taxes & fees
1 Nov - 2 Nov
Melody rooms
A balcony with a table set for two, a chair, and a view of a building with multiple windows and balconies.

8. B&B Nike

B&B Nike
Santa Lucia
9.0 out of 10, Wonderful, (93 reviews)
"The room and bathroom were large and clean. The mattress and sheets were fantastic. The room had air conditioning. The host was there at check in and was easily accessible. The location was great- just outside Ortigia. Parking was easy and close. An overall nice place to stay."
Canada
Chris
The price is ฿2,611
฿2,977 total
includes taxes & fees
25 Nov - 26 Nov
B&B Nike
A terrace with white tables and chairs, white umbrellas, and a view of the sea.

9. Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (134 reviews)
"We had an amazing time. Sabrina and Claudia were wonderful. The place is top notch in everything they do. The food was so fresh and delicious . I was sad when i had to leave them. High praise for this hotel. The views breath taking."
United States
Duane
The price is ฿6,879
฿7,945 total
includes taxes & fees
10 Nov - 11 Nov
Giuggiulena Villa
A balcony with potted plants and a metal railing.

10. Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (388 reviews)
"Very old fashioned,poor shower,no coat hangers in wardrobe and no drawers. Hard bed,basic breakfast.Good location and quiet in hotel."
United Kingdom
PETER
Piccolo Hotel Casa Mia
A hot tub with a view of a marina.

11. Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
8.8 out of 10, Excellent, (3 reviews)
"This was one of the best hotel stays I’ve ever had. Simply, you won’t be disappointed from location, excellent service and the most helpful and welcoming staffs. Highly recommended"
United States
Hossein
The price is ฿7,241
฿8,344 total
includes taxes & fees
5 Nov - 6 Nov
Casa Miranda Boutique
A modern dining area with a white table, green chairs, and a potted plant.

12. San Nicola Rooms Siracusa

San Nicola Rooms Siracusa
Santa Lucia
8.8 out of 10, Excellent, (15 reviews)
"The breakfast was great! The hosts were super friendly and helpful!"
United States
Lin
The price is ฿3,961
฿4,515 total
includes taxes & fees
30 Oct - 31 Oct
San Nicola Rooms Siracusa
An open balcony with a table and chairs, potted plants, and a view of a building with balconies and windows.

13. Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
9.8 out of 10, Exceptional, (19 reviews)
"The B&B owner Anna was really friendly and helpful. The hotel was centrally located, a few minutes walk from Ortigia. The room was spacious and really clean!"
Finland
Petri
The price is ฿4,557
฿5,195 total
includes taxes & fees
2 Nov - 3 Nov
Calafatari B&B
A hotel room with a bed, a desk, a chair, a TV, and a balcony with a view of buildings.

14. Syraka Design Rooms & Suites

Syraka Design Rooms & Suites
Santa Lucia
The price is ฿3,424
฿3,903 total
includes taxes & fees
2 Nov - 3 Nov
Syraka Design Rooms & Suites
A bedroom with a stone wall, a bed with a wooden headboard, a tray with a plant, and a window with curtains.

15. B&B Siracusa

B&B Siracusa
Santa Lucia
8.8 out of 10, Excellent, (61 reviews)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is ฿2,613
฿2,979 total
includes taxes & fees
8 Nov - 9 Nov
B&B Siracusa
A marina with numerous boats docked, a clear sky, and a building with outdoor seating.

16. Regina Margherita

Regina Margherita
Santa Lucia
7.8 out of 10, Good, (22 reviews)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
The price is ฿1,884
฿2,148 total
includes taxes & fees
9 Nov - 10 Nov
Regina Margherita
A woman in a black swimsuit sitting in a hot tub overlooking a beach with a clear sky and the sun shining.

17. Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.6 out of 10, Excellent, (59 reviews)
"Wonderful property, excellent staff and the most amazing view from the apartment"
Australia
Anthony
The price is ฿8,857
฿10,121 total
includes taxes & fees
1 Nov - 2 Nov
Re Dionisio Luxury Suites
A table with two wine glasses and a decorative item, viewed through a window overlooking a parking area with cars and greenery.

18. Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (44 reviews)
"Nice kitchen area, centrally located."
United States
Richard
The price is ฿1,950
฿2,222 total
includes taxes & fees
4 Nov - 5 Nov
Gymnasium
A modern bedroom with a bed, bedside table, and a unique feature of a table with a fire effect.

19. B&B IL MORO

B&B IL MORO
Santa Lucia
4.0 out of 10, (1 review)
"Personne sur place pour nous aider. La carte de la chambre était défectueuse dès l'arrivée. Par la suite l'électricité a manqué à 21h, nous avons du contacter les propriétaires via What's App dans le noir. Nous apprécions faire affaire avec des humains et non des applications impersonnelles et des vidéos. Le lit était petit et inconfortable. Pas d'oreiller d'extra ni de boîte de mouchoirs. Le quartier est lugubre."
Canada
Celine B. La
The price is ฿1,872
฿2,997 total
includes taxes & fees
7 Nov - 8 Nov
B&B IL MORO
A modern hotel room with a bed, a bedside table, a decorative wall, and a shower area.

20. B&B L'INFIORESCENZA

B&B L'INFIORESCENZA
Santa Lucia
7.0 out of 10, Good, (4 reviews)
"A pretty good value place in Siracusa, it's not far from Ortigia so save yourself a bit of money. It's clean and the bedroom is comfy, plus all the essentials are provided, as well as a voucher for a free breakfast at the cafe downstairs. The only downside is the somewhat odd and cramped layout of the property: the bedroom and the downstairs bit are pretty spacious, but there is a narrow spiral staircase connecting them and if you want to carry your suitcases up it's a bit of a pain. Also when...
United Kingdom
Adrian
The price is ฿953
฿1,518 total
includes taxes & fees
27 Oct - 28 Oct
B&B L'INFIORESCENZA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.
A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

Ancient ruins with a large amphitheater surrounded by trees.
Photo by William Keller
Open Photo by William Keller

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

An aerial view of a coastal city with a prominent fortified structure and a densely built urban area in the background.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Top Santa Lucia Hotel Reviews

Nostos rooms & Apartments

Nostos rooms & Apartments

10/10 Excellent
"Very good situation between Ortigia and Syracuse, no car needed. Modern and clean."
Evelyne 2-night trip
Posted 4 hours ago
Nostos rooms & Apartments

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Lucia?
Based on our traveller data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.
How many hotels will I find in Santa Lucia?
Expedia has 313 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.