Search Luxury Hotels in Santa Cruz

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Tonight
31 Dec - 1 Jan
Tomorrow
1 Jan - 2 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Our top choices for Santa Cruz luxury hotels

Terrace/patio
Hotel Cava Colchagua

Hotel Cava Colchagua

Hotel Cava Colchagua
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (170)
"Interesting and beautiful place to stay. Barrel rooms are comfortable. Staff are very pleasant and accomodating. Food at the restaurant was fantastic. Shower was not the best."
Canada
Anonymous traveller
Hotel Cava Colchagua
Outdoor pool, pool loungers
Santa Cruz Plaza

Santa Cruz Plaza

Santa Cruz Plaza
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (336)
"Yes all great."
United States
Barrett
The price is ฿4,090
฿4,090 total
13 Jan - 14 Jan 2026
Santa Cruz Plaza
Front of property
Barrica Lodge

Barrica Lodge

Barrica Lodge
4.0 star property
Santa Cruz
8.0 out of 10, Very good, (1)
The price is ฿4,323
฿4,323 total
12 Jan - 13 Jan 2026
Barrica Lodge
Egyptian cotton sheets, premium bedding, minibar, in-room safe
Vik Chile

Vik Chile

Vik Chile
5.0 star property
San Vicente
9.2 out of 10, Wonderful, (157)
"If I could rate this place 11/10 I would. Despite the fact the hotel and surrounding grounds are incredible, the staff and experiences are what make this place. We have never been somewhere with such exceptional service. Would highly recommend the trip out of Santiago to anyone visiting Chile"
United Kingdom
Amy
The price is ฿21,999
฿21,999 total
7 Jan - 8 Jan 2026
Vik Chile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
During your visit, you might want to enjoy the tours which Santa Cruz is known for.
What's the best high-end hotel in Santa Cruz?
Vibo Wine Lodge is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travellers looking for an elegant place to stay.
When can I expect good weather in Santa Cruz?
Planning for the weather is an important factor for making your trip to Santa Cruz a success, especially when you're splurging. The hottest months are usually January and February, with an average temperature of 21°C, while the coldest months are July and August, with an average of 10°C. Average annual precipitation for Santa Cruz is 743 mm.
What's there to see and do in Santa Cruz?
Experience all that Santa Cruz has to offer when you visit Museo de Colchagua, Casino Colchagua and Colchagua Campo y Vino. If you have some spare time during your trip, you might want to check out Lapostolle Clos Apalta Winery and Millahue Valley.