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24 Dec - 25 Dec
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25 Dec - 26 Dec
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26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Santa Cruz hotels

Front of property
Hotel Vendimia Parador

Hotel Vendimia Parador

Hotel Vendimia Parador
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (79)
Set in the heart of wine country, this colonial hotel offers both outdoor and indoor swimming options near Laura Hartwig Winery and Plaza de Armas. Enjoy complimentary WiFi and parking while attentive staff ensure a memorable stay.
"Great place for a weekend of wines and relax. My gf and I really enjoyed the facilities, good breakfast, owners provide great customer service. "
United States
Stephen
The price is ฿3,079
฿3,079 total
18 Jan - 19 Jan 2026
Hotel Vendimia Parador
Seasonal outdoor pool, pool loungers
La Perla Hotel

La Perla Hotel

La Perla Hotel
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (101)
Experience Santa Cruz with this hotel's outdoor pool and children's wading area. Unwind at the bar or rejuvenate with a massage. Explore the Colchagua Museum and Plaza de Armas nearby. Enjoy free Wi-Fi and parking during your stay.
"Nice stay"
United States
George
La Perla Hotel
Outdoor pool, pool loungers
Santa Cruz Plaza

Santa Cruz Plaza

Santa Cruz Plaza
4.0 star property
Santa Cruz
8.6 out of 10, Excellent, (335)
Discover Santa Cruz comfort with an outdoor pool and free kids' club near Museo de Colchagua. After massages and hydrotherapy at the full-service spa, enjoy drinks at the bar or snacks at the café while the helpful staff ensures a memorable stay.
"Yes all great."
United States
Barrett
The price is ฿3,950
฿3,950 total
25 Dec - 26 Dec
Santa Cruz Plaza
Couples treatment room(s), hot springs/mineral springs, massages
Hotel Cava Colchagua

Hotel Cava Colchagua

Hotel Cava Colchagua
4.0 star property
Santa Cruz
8.8 out of 10, Excellent, (170)
Immerse yourself in wine country at this Santa Cruz sanctuary. Located near the train station, you'll enjoy the on-site winery, full-service spa treatments, and outdoor pool. Laura Hartwig Winery and Colchagua Campo y Vino await nearby.
"Interesting and beautiful place to stay. Barrel rooms are comfortable. Staff are very pleasant and accomodating. Food at the restaurant was fantastic. Shower was not the best."
Canada
Anonymous traveller
Hotel Cava Colchagua
Aerial view
TerraViña

TerraViña

TerraViña
3.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (203)
Immerse yourself in Chilean wine country at this inviting estate. Enjoy the outdoor pool after a day of tastings at the on-site winery. The restaurant, garden terrace, and nearby Laura Hartwig Winery create a perfect wine-lovers escape.
"It is situated in the midfle of a vineyard - so it is certainly quiet. Great base for exploring (by own car or taxi) the Uco Valley. It is a 20 minute walk to the road! Simple but stylish place. Gym is just for show… $300 dollars would sort it out! Staff were very helpful. This is a unique place for a wine aficionado! "
United Kingdom
Paul
The price is ฿5,039
฿5,039 total
25 Dec - 26 Dec
TerraViña
Outdoor pool, pool umbrellas, pool loungers
Hotel Boutique Solaz Bella Vista de Colchagua

Hotel Boutique Solaz Bella Vista de Colchagua

Hotel Boutique Solaz Bella Vista de Colchagua
3.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (96)
In the heart of Santa Cruz, this boutique hotel offers massages and body treatments at the spa. Swim in the outdoor pool, sip drinks at the bar, and explore nearby Laura Hartwig Winery with free parking and WiFi.
"Wonderful place, great people, access to wine tastings."
United States
Irving
The price is ฿2,856
฿2,856 total
26 Dec - 27 Dec
Hotel Boutique Solaz Bella Vista de Colchagua
Terrace/patio
Barrica Lodge

Barrica Lodge

Barrica Lodge
4.0 star property
Santa Cruz
8.0 out of 10, Very good, (1)
Escape to this charming lodge near MontGras Winery. A seasonal outdoor pool refreshes after exploring nearby hiking trails, while free breakfast, WiFi and parking enhance your Santa Cruz wine country stay. Enjoy the garden and terrace.
The price is ฿4,279
฿4,279 total
12 Jan - 13 Jan 2026
Barrica Lodge
Interior detail
Hotel Boutique Grand Cru

Hotel Boutique Grand Cru

Hotel Boutique Grand Cru
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (8)
This Chilean hotel with an outdoor pool and soothing steam room offers the perfect base for exploring. Located near Museo de Colchagua and Plaza de Armas, enjoy complimentary breakfast, WiFi, and parking during your stay.
"Excellent staff, beautiful rooms and amenities "
United States
Jonathan
The price is ฿3,635
฿3,635 total
25 Dec - 26 Dec
Hotel Boutique Grand Cru
Outdoor pool, pool loungers
Casa Calfu

Casa Calfu

Casa Calfu
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (63)
This relaxed B&B in Santa Cruz offers poolside lounging under the Chilean sun and garden strolls. Close to Plaza de Armas and Museo de Colchagua, guests enjoy complimentary breakfast, WiFi, and parking for easy wine country adventures.
"Charming place ! "
France
Ruxandra
Casa Calfu
Courtyard
Hotel Boutique Vendimia Premium

Hotel Boutique Vendimia Premium

Hotel Boutique Vendimia Premium
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (136)
Set in Chile's entertainment district, this colonial hotel offers a seasonal outdoor pool, children's pool, and terrace near Museo de Colchagua and Plaza de Armas. Free WiFi and parking add extra value to your wine country escape.
"Loved the rustic hotel and Mauricio and Carla are awesome hosts! Great location and an amazing place to stay. Highly recommended. "
United States
Orlando
The price is ฿3,779
฿3,779 total
25 Dec - 26 Dec
Hotel Boutique Vendimia Premium
1 bedroom, laptop workspace, free WiFi
Colchagua Tiny Lodge

Colchagua Tiny Lodge

Colchagua Tiny Lodge
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (4)
Rustic charm meets modern comfort at this Santa Cruz lodge with private hot tubs in each cabin. Explore nearby wineries like Lapostolle and Viña Viu Manent, then relax on the terrace surrounded by garden views.
"The Tiny Lodge has so many amenities thoughtfully packed into a cozy package. Loved the thought put into surfaces and spaces to sit your personal belongings. The bed is luxurious. 10 out of 10. "
United States
Trisha
The price is ฿6,339
฿6,339 total
25 Dec - 26 Dec
Colchagua Tiny Lodge
Separate bathtub and shower, deep-soaking bathtub, free toiletries
Vik Chile

Vik Chile

Vik Chile
5.0 star property
San Vicente
9.2 out of 10, Wonderful, (157)
Immersed in San Vicente's wine country, this luxury retreat offers two restaurants including Milla Milla serving international cuisine. The outdoor pool and spa treatments complement vineyard explorations, while free breakfast fuels adventures to nearby Viña Vik.
"If I could rate this place 11/10 I would. Despite the fact the hotel and surrounding grounds are incredible, the staff and experiences are what make this place. We have never been somewhere with such exceptional service. Would highly recommend the trip out of Santiago to anyone visiting Chile"
United Kingdom
Amy
The price is ฿21,752
฿21,752 total
7 Jan - 8 Jan 2026
Vik Chile
Seasonal outdoor pool, pool umbrellas, pool loungers
Noi Blend Colchagua

Noi Blend Colchagua

Noi Blend Colchagua
3.0 star property
Palmilla
9.0 out of 10, Wonderful, (137)
Enjoy regional cuisine at Ensamblaje Restaurant after a day exploring nearby Viña Maquis and MontGras Winery. This Palmilla hotel offers free breakfast, massage services, and a seasonal outdoor pool with a poolside bar, all praised by travellers for its exceptional staff.
"Great place, attentive staff, made our stay very enjoyable. "
United States
Raymond
The price is ฿4,653
฿4,653 total
25 Dec - 26 Dec
Noi Blend Colchagua
Exterior
Hotel Ontiveros

Hotel Ontiveros

Hotel Ontiveros
3.5 star property
San Fernando
9.6 out of 10, Exceptional, (21)
Elegant accommodation at this welcoming retreat come with complimentary breakfast, WiFi, and parking. Unwind at the bar/lounge or enjoy a meal at the restaurant. The garden and terrace offer peaceful spots to relax near Iglesia de San Francisco.
"Amplia y comoda habitacion. Personal de recepcion muy amable y colaborador "
Mexico
Eileen
Hotel Ontiveros
Seasonal outdoor pool, open 10:00 AM to 8:00 PM, pool umbrellas
Hacienda Histórica Marchigüe

Hacienda Histórica Marchigüe

Hacienda Histórica Marchigüe
3.5 star property
Marchihue
8.0 out of 10, Very good, (13)
Escape to wine country in Marchihue, where this hacienda offers poolside relaxation, fitness centre, and pampering spa treatments. Savour meals at the restaurant after exploring nearby Clos Santa Ana Winery.
"An unusual place to stay. the staff were great and very helpful. Enjoyed the quiet and food"
United States
Anonymous traveller
Hacienda Histórica Marchigüe
Interior detail
Hotel Boutique Raices

Hotel Boutique Raices

Hotel Boutique Raices
3.5 star property
Curicó
9.4 out of 10, Exceptional, (40)
Relax with a drink at the inviting bar or grab a bite at the café. Just 8 minutes from Curicó Station and near Plaza de Armas, this hotel offers free breakfast, WiFi, and parking for a comfortable business trip.
"I enjoyed my stay here. "
Canada
Nick
Hotel Boutique Raices
Premium Twin | Free WiFi, bed sheets
Hotel Viña La Playa

Hotel Viña La Playa

Hotel Viña La Playa
3.5 star property
Peralillo
8.2 out of 10, Very good, (17)
Unwind at this countryside sanctuary offering indulgent spa treatments, fusion cuisine at Tinguiririca restaurant, and tennis courts. Near Hacienda El Huique, this hotel combines vineyard charm with recreation and complimentary breakfast.
"Nice place, if you want to rest this is the place"
Mexico
Manuel
Hotel Viña La Playa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Cruz attractions

Lapostolle Clos Apalta Winery

4.7/5 (10 reviews)
Carved into the hillside, Clos Apalta Winery produces award-winning Bordeaux-style wines using a gravitational system. Reserve a private tour to taste premium vintages overlooking the stunning Colchagua Valley.
See properties

Casino Colchagua

Chile's first thematic casino blends gaming with colonial-inspired decor that celebrates local heritage. Enjoy slot machines and table games while savouring Chilean cuisine from the adjacent Hotel Santa Cruz Plaza.
See properties

Learn more about Santa Cruz

Nestled in the heart of wine country, Santa Cruz invites visitors to taste world-class Colchagua Valley wines at family-owned vineyards. Museum of Colchagua showcases impressive pre-Columbian artefacts while the Plaza de Armas offers local crafts and regional foods on weekends.

See all hotels in Santa Cruz
Rows of vineyards, Santa Cruz, Chile

Top Santa Cruz Hotel Reviews

Hotel Boutique Grand Cru

Hotel Boutique Grand Cru

10/10 Excellent
"We thoroughly enjoyed our time with the great people who own and manage this hidden gem."
Jim 2-night trip
Posted 4 days ago
Hotel Boutique Grand Cru

More cheap stays in Santa Cruz

Hostal Vida 2000

Hostal Vida 2000

Ismael Valdes 245 Santa Cruz
Get rates

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Hotel Vendimia Parador is a favourite property for Expedia customers. This hotel offers an outdoor pool and an indoor pool. Reviews from our site also recommend Casa Calfu and La Perla Hotel as top options for your visit. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
Hosteria No me Olvides: This holiday home rental outside Santa Cruz offers a terrace and cable TV to help you feel comfortable in your new surroundings. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! The majority of hotel room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's the best place to stay on a budget in Santa Cruz?
Based on our traveller reviews, Hostal Gomero is a top choice for a less expensive stay. Other options to stay on the cheap include Casa Suiza - Hostel and Hostal Cepa Noble. View all budget hotels in Santa Cruz.
What's the best family accommodation in Santa Cruz?
Santa Cruz Plaza is a hotel with an outdoor pool and a free children's club, and it's a top choice on Expedia for families. Also, children of all ages will enjoy a visit to Colchagua Campo y Vino. Find more child-friendly accommodations in Santa Cruz.
What's the best dog-friendly accommodation option in Santa Cruz?
Hotel Vendimia Parador is a top hotel for people travelling with their pets, and offers an indoor pool and an outdoor pool for its human guests. Two other good options for you and your pet include Hotel Hoja de Parra and El Refugio de Santa Cruz. See more pet-friendly hotel accommodations in Santa Cruz.
What's the best luxury hotel in Santa Cruz?
Vibo Wine Lodge is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Find more luxury hotels in Santa Cruz.
What are some accommodation options with pools in Santa Cruz?
Hotel Vendimia Parador is a top hotel with an indoor pool, an outdoor pool and free WiFi. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Santa Cruz Plaza is a top spa hotel featuring a rooftop terrace, a 24-hour fitness centre, a free children's club and a bar. Treat yourself to a facial, body scrub or hydrotherapy at the on-site spa. Other popular spa hotels in Santa Cruz include Hotel Cava Colchagua and Hotel Boutique Solaz Bella Vista de Colchagua. See all spa hotels in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely enjoy the wineries, local tours and restaurants. Tourists can also enjoy so much more including its casinos. In Santa Cruz, there are 34 hotels and other accommodation options to choose from. Find out more about Santa Cruz.
What is there to see in Santa Cruz?
Wine tasting is a great activity, and Lapostolle Clos Apalta Winery is one place to visit. A couple of additional sights to add to your itinerary are Casino Colchagua and Millahue Valley. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
What's the seasonal weather in Santa Cruz?
The hottest months are usually January and February, with an average temperature of 21°C, while the coldest months are July and August, with an average of 10°C. Average annual precipitation for Santa Cruz is 743 mm.