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Check prices for these dates

In two weeks
30 Oct - 1 Nov
In two months
11 Dec - 13 Dec
In three months
8 Jan - 10 Jan
In four months
5 Feb - 7 Feb

Our top choices for Santa Cruz holiday rentals

A neatly made bed with a wooden headboard, a bedside table with a bottle and a glass, and a chair in a bright room with a large window.

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (297 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is ฿2,284
฿2,284 total
13 Oct - 14 Oct
Portal del Rodeo ApartaHotel - Arkadia Mall
A modern hotel room with a large bed, a desk, a chair, a potted plant, and a view of the mountains.

2. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (139 reviews)
"Excellent Stay!"
United States
Esdras
The price is ฿1,646
฿1,646 total
13 Oct - 14 Oct
Go Living and Suites by Jalo
A woman standing by a balcony with a view of a rural landscape.

3. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (495 reviews)
"Very clean and a good rear view of landscape"
United States
roberto
The price is ฿3,576
฿3,576 total
13 Oct - 14 Oct
Travelers Rio Verde Living Suites
A modern living room with a large window, a sofa set, a coffee table, and a potted plant.

4. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.0 out of 10, Wonderful, (92 reviews)
"Clean, good location, nice staff"
United States
Sau Yeng
The price is ฿1,473
฿2,210 total
26 Oct - 27 Oct
Metropolitan Living by HOUSY
A modern hotel room with a bed, bedside table, lamp, and a TV.

5. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (219 reviews)
"VERY CONVENIENT, CLOSE TO EVERYTHING AND SAFE."
United States
Rulph
The price is ฿1,935
฿1,935 total
13 Oct - 14 Oct
Origen Local Suites
A modern apartment with a living area, kitchenette, and large windows offering city views.

6. Kyux by Jalo

Kyux by Jalo
4.0 star property
Laureles
9.2 out of 10, Wonderful, (189 reviews)
"Great hotel highly recommended will stay again"
United States
Howard
The price is ฿1,730
฿1,730 total
18 Oct - 19 Oct
Kyux by Jalo
A modern hotel room with a large bed, a flat-screen TV, and a view of the city through large windows.

7. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (145 reviews)
"The staff were terrific and helpful. The room was perfect in an ideal location."
United States
Amy
The price is ฿2,452
฿3,398 total
20 Oct - 21 Oct
Factory Lofts
A modern interior with marble flooring, a reception area, and a seating area with tables and chairs.

8. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (747 reviews)
"Haven is the best"
United States
JASON
The price is ฿3,033
฿3,033 total
28 Oct - 29 Oct
Haven, A Design Hotel
An outdoor café with tables and chairs, surrounded by potted plants and a view of buildings.

9. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (106 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is ฿1,508
฿1,508 total
13 Oct - 14 Oct
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
A balcony with a hot tub, wooden steps, and a potted plant.

10. Wake Living

Wake Living
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (235 reviews)
"Great place"
United States
Pedro
The price is ฿5,982
฿5,982 total
14 Oct - 15 Oct
Wake Living
A modern restaurant with high ceilings, large windows, and a city view. Tables are set with dishes and drinks.

11. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (75 reviews)
"Room was as expected, didn’t reward the fine print of cooling condition for the room , had a fan available in the room which helped. Appreciate the host, and the security of the building and room especially being I was a solo traveler"
United States
jocelyne
The price is ฿1,599
฿1,599 total
15 Oct - 16 Oct
Edificio Helena
A modern hotel room with a large bed, a TV mounted on the wall, and a view of the cityscape through large windows.

12. HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (111 reviews)
"The staff was helpfull"
United States
Elsje
The price is ฿1,765
฿2,838 total
13 Oct - 14 Oct
HOUSY Laureles
A modern hotel room with a large bed, a small table, a potted plant, and a city view through the window.

13. Estelar Apartamentos Medellin

Estelar Apartamentos Medellin
3.5 star property
El Poblado
8.8 out of 10, Excellent, (500 reviews)
"Great location"
United States
Andrew
The price is ฿4,084
฿4,084 total
16 Oct - 17 Oct
Estelar Apartamentos Medellin
A modern bedroom with a large bed, a built-in wardrobe, a kitchen area, and a balcony with plants.

14. Living by Armoniko

Living by Armoniko
4.0 star property
Laureles
9.6 out of 10, Exceptional, (85 reviews)
"Amazing gem in Laureles! This place is addictive and I will surely return and reccommend to others for staying in Medellin. Great service, beautiful and clean property and facilities @ great value."
United States
Ryan
The price is ฿4,053
฿4,263 total
13 Oct - 14 Oct
Living by Armoniko
A rooftop patio with tables and chairs, a bar area, and a view of the cityscape.

15. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (26 reviews)
"Exceptionally friendly staff, the property is top notch. Cafe Soler is incredible."
United States
Frederick
The price is ฿1,790
฿1,790 total
13 Oct - 14 Oct
B 48 Living by B Rent
A modern living room with a large window, a sofa, a coffee table, and a kitchen area with a marble island.

16. Loft 43

Loft 43
3.0 star property
Laureles
8.8 out of 10, Excellent, (37 reviews)
"We stayed 1 week. The unit was clean, friendly staff and location was the best. Near several restaurants, grocery. Not noisy"
United States
Mario
The price is ฿1,930
฿1,930 total
26 Oct - 27 Oct
Loft 43
A person relaxing in a hot tub with a scenic view of mountains and clouds.

17. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (44 reviews)
"Good location with amazing views, a bit difficult finding . But overall great place to visit."
United States
Giovanni
The price is ฿1,979
฿2,482 total
20 Oct - 21 Oct
Skyline Ecoliving
A building with a brick facade, storefronts for jewelry and MUZEM, and a tree in front.

18. Living 10-36 Dieztreintayseis Short & Long Term

Living 10-36 Dieztreintayseis Short & Long Term
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (65 reviews)
"Loved the room I stayed in and the staff was always accommodating. Great Boutique Hotel to stay."
United States
Rob
The price is ฿2,299
฿2,299 total
14 Oct - 15 Oct
Living 10-36 Dieztreintayseis Short & Long Term
A modern living room with a white sofa, round coffee table, and a dining area with a wooden table and chairs.

19. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very good, (460 reviews)
"Great location, secure place, quiet, private parking"
United States
CAMILO
The price is ฿1,602
฿3,111 total
26 Oct - 27 Oct
Apartment Go Living & Suites by HOUSY HOST
A rooftop terrace with two hot tubs, a dining area with chairs and a table, and a view of a cityscape with mountains in the background.

20. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (114 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
The price is ฿1,673
฿1,673 total
13 Oct - 14 Oct
Quadrato Studios
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Blues Suites Medellin

Blues Suites Medellin

10/10 Excellent
"Muy comodo"
Israel 1-night trip
Posted 1 hour ago
Blues Suites Medellin

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a holiday rental in Santa Cruz?

Yes, there are holiday rentals close to the most popular sights in Santa Cruz, or you can select a more secluded option if you're looking for a relaxing stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the wider area, you’ll find University of Antioquia and Arvi Park.

What’s a holiday rental in Santa Cruz like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Santa Cruz. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can offer a sense of safety away from public hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also find more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a popular option for families.