A beach with waves, a boat, and a forested hill in the background.

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Check prices for these dates

In two weeks
23 Oct - 25 Oct
In two months
4 Dec - 6 Dec
In three months
1 Jan - 3 Jan
In four months
29 Jan - 31 Jan

Our top choices for Santa Clara holiday rentals

A beach with rocky terrain and a distant building.

1. Habitación con entrada Privada en Playa Dorada + Kitchenette y baño.

Habitación con entrada Privada en Playa Dorada + Kitchenette y baño.
3.0 star property
Vacamonte
8.4 out of 10, Very good, (5 reviews)
"Really recommended! Omar is a superhost, very helpfull and lovely! Good facilities and there is a swimmingpool and a nice little beach."
United States
Cynthia
The price is ฿652
฿1,004 total
includes taxes & fees
11 Oct - 12 Oct
Habitación con entrada Privada en Playa Dorada + Kitchenette y baño.
An outdoor seating area with tables and chairs, a view of the beach, and string lights.

2. Refugio Frente al Mar Vista Venao

Refugio Frente al Mar Vista Venao
3.0 star property
Veracruz
7.4 out of 10, Good, (3 reviews)
"The staff was very welcoming, the room was very clean and had all the commodities needed for a great experience! I highly recommend it and I'll definitely pay a second visit!"
United States
Victor
The price is ฿1,962
฿2,158 total
includes taxes & fees
11 Oct - 12 Oct
Refugio Frente al Mar Vista Venao
A modern hotel room with a large bed, bedside tables with lamps, and artwork on the walls.

3. La Palma Experience

La Palma Experience
3.0 star property
Amador
8.2 out of 10, Very good, (14 reviews)
"I would recommend this hotel. It has a great location and offers a very pleasant experience."
United States
Juan Luis Perez
The price is ฿2,640
฿2,905 total
includes taxes & fees
11 Oct - 12 Oct
La Palma Experience
A modern outdoor swimming pool with a clear view of a tall building in the background.

4. Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
4.0 star property
San Francisco
8.6 out of 10, Excellent, (38 reviews)
"Modern and clean, including a pool and gym with stunning view. Staff were wonderful. Basic but good breakfast included. Better than a hotel."
United States
David
The price is ฿5,190
฿5,709 total
includes taxes & fees
9 Nov - 10 Nov
Dovle Residences by HMS-Preferred Member
A modern living room with a sofa, a coffee table with flowers, a TV, and a large window with a city view.

5. Boutique Apartments Panamá Coco del Mar

Boutique Apartments Panamá Coco del Mar
3.5 star property
San Francisco
7.8 out of 10, Good, (236 reviews)
"very nice place to stay"
United States
purabi
The price is ฿1,569
฿6,427 total
includes taxes & fees
12 Oct - 13 Oct
Boutique Apartments Panamá Coco del Mar
A rooftop pool with lounge chairs, offering a city view.

6. Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
8.0 out of 10, Very good, (49 reviews)
"Staff was great. Room has spectacular views. Air conditioning was great, super quiet in the bedroom. Rooftop pool and patio was delightful. Loved our stay!"
Canada
Gary
The price is ฿1,134
฿4,916 total
includes taxes & fees
11 Oct - 12 Oct
Boutique Apartments Atlapa
A rooftop pool with a city view, lounge chairs, and a clear sky.

7. Corporate Stays Arcadia | Executive Furnished Apartments

Corporate Stays Arcadia | Executive Furnished Apartments
4.0 star property
Costa del Este
9.2 out of 10, Wonderful, (394 reviews)
"Nice place good location"
United States
Rame
The price is ฿3,219
฿3,762 total
includes taxes & fees
29 Oct - 30 Oct
Corporate Stays Arcadia | Executive Furnished Apartments
Living room

8. Cozy La Chorrera Villa With Private Patio & Nature Views

Cozy La Chorrera Villa With Private Patio & Nature Views
2.0 star property
La Chorrera
The price is ฿1,746
฿1,921 total
includes taxes & fees
10 Nov - 11 Nov
Cozy La Chorrera Villa With Private Patio & Nature Views
A modern living room with a sofa, a TV, a small table, and a balcony with a view of the city.

9. Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
9.0 out of 10, Wonderful, (2 reviews)
"Perfect"
United States
Lorenz
The price is ฿1,503
฿6,793 total
includes taxes & fees
1 Nov - 2 Nov
Living 73 Panamá by Boutique Apartments
A spacious indoor courtyard with tiled flooring, multiple seating areas, and hanging plants.

10. La Isabela Suites

La Isabela Suites
3.5 star property
Casco Viejo
10.0 out of 10, Exceptional, (212 reviews)
"Location in old town, across from Plaza Simon Bolivar, is the perfect place to venture around old town and the new city. Great restaurants and shops within easy walking distance. I relied on recommendations from the staff for a couple of things and their selections exceeded my expectations. Highly recommend staying if visiting Panama City."
United States
David
The price is ฿5,281
฿5,809 total
includes taxes & fees
25 Oct - 26 Oct
La Isabela Suites
A playground with slides and climbing structures, surrounded by a fenced area with a view of tall buildings.

11. The Hub by Boutique Apartments

The Hub by Boutique Apartments
3.0 star property
San Francisco
The price is ฿1,405
฿5,904 total
includes taxes & fees
20 Oct - 21 Oct
The Hub by Boutique Apartments
Balcony

12. San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (65 reviews)
"Wonderful location. The staff is very friendly. I highly recommend a Coffee Shop right at the entrance: "La Vasquita"."
United States
Georg
The price is ฿3,667
฿4,872 total
includes taxes & fees
13 Oct - 14 Oct
San Francisco by Wynwood House
A modern hotel lobby with a marble staircase, seating areas, and a large mirror reflecting the space.

13. Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
Bella Vista
8.8 out of 10, Excellent, (589 reviews)
"Good stay here. Breakfast buffet was limited but good. Staff very friendly and helpful."
United States
Nalisa
The price is ฿3,101
฿3,412 total
includes taxes & fees
11 Oct - 12 Oct
Torres de Alba Hotel & Suites
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

14. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (110 reviews)
"It is a new place, an apartment was in pristine condition. The building is 2 blocks away from the old town."
United States
Arshak Andrew
The price is ฿2,806
฿4,093 total
includes taxes & fees
11 Oct - 12 Oct
Casco View Life Residences
A rooftop pool area with lounge chairs and a table, overlooking a cityscape with tall buildings.

15. Boutique Apartments Panama

Boutique Apartments Panama
3.5 star property
Bella Vista
8.0 out of 10, Very good, (392 reviews)
"Great stay!!!!"
United States
fitz
The price is ฿1,326
฿5,127 total
includes taxes & fees
11 Oct - 12 Oct
Boutique Apartments Panama
A rooftop pool with lounge chairs and a cityscape view.

16. Marriott Executive Apartments Panama City, Finisterre

Marriott Executive Apartments Panama City, Finisterre
4.0 star property
Bella Vista
8.8 out of 10, Excellent, (774 reviews)
"Front desk staff were very friendly and accommodating. Clear communication throughout my stay. Breakfast varied day to day which was nice. Enjoyed the omelette bar. Overall great location and clean spacious rooms."
United States
Markeisha
The price is ฿3,962
฿4,358 total
includes taxes & fees
30 Oct - 31 Oct
Marriott Executive Apartments Panama City, Finisterre
A modern hotel entrance with a well-lit facade, a prominent sign, and a landscaped garden area.

17. Yoo Panamá by Boutique Apartments

Yoo Panamá by Boutique Apartments
3.5 star property
Bella Vista
8.0 out of 10, Very good, (142 reviews)
"It was a very beautiful property and prime location! All around experience was great!"
United States
Michelle
The price is ฿1,600
฿6,421 total
includes taxes & fees
1 Nov - 2 Nov
Yoo Panamá by Boutique Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Clara Hotel Reviews

Megapolis Hotel Panamá

Megapolis Hotel Panamá

10/10 Excellent
"Hgghhggghhvhchughugg. Hughhggg"
joel 1-night trip
Posted less than an hour ago
Megapolis Hotel Panamá

Find out more about Santa Clara

Search for holiday rentals in Santa Clara on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Clara using one of the methods below:

  • View our selection of featured holiday rentals in Santa Clara
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  • Enter your travel dates to view the best deals on holiday rentals in Santa Clara while they last

Look no further and take a look at our great range of rental properties in Santa Clara!

Frequently asked questions

Can I find holiday rentals in Santa Clara?

Yes, there are holiday rentals close to the most popular sights in Santa Clara, or you can select a more secluded option if you're looking for a relaxing stay. Santa Clara is known for its monuments.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the wider area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are holiday rentals like in Santa Clara?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santa Clara. Holiday rentals offer extras like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, holiday rentals can provide a sense of privacy away from shared hotel lifts and busy lobbies while still allowing you to travel. You'll also have more space in a holiday rental than in a standard hotel, which makes a holiday rental a popular option for a family trip or a small group gathering.