The Best Hotels in Santa Ana, Panama City - 2026 Updated Prices

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Compare popular hotels in Santa Ana

Property	Property class	Guest rating
Casco View Apartments	3.5 star property	9.0 Wonderful 94 reviews	View
Hostal La Cigarra	2.0 star property	7.6 Good 71 reviews	View
Hotel República	2.0 star property	6.8 193 reviews	View
ART CASCO The Hotel	2.0 star property	6.0 11 reviews	View
Hotel Riazor	3.0 star property	3.8 11 reviews	View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

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Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

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Panama City Old Town streets and buildings

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

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The Bridge of the Americas in summer, Panama City

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

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Panoramic view of Panama City Skyline - Panama City, Panama

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Estación Lotería or Santo Tomas Station to explore sights like Via Espana.

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Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

10/10 Excellent

"Todo limpio buen trato personal amable muy confortable el bufet muy bueno toda variedad y buena higiene en fin la pasamos espectacular"

Las Americas Golden Tower Panama

6/10 Okay

"The location was great! The room was nice with a coffeemaker and refrigerator, but the bathroom area could use an upgrade. Breakfast was mediocre and the restaurant service was slow and food okay. The dinner we had on our first night was very good; however, we had a problem getting 20% off that meal, which Expedia said we could have. The best thing was one of the young men at the concierge desk (can’t remember his name) but he was a delight!"

The Executive Hotel

8/10 Good

"The room was rather small and Hotel is centrally located. I will say that the highlight was the friendly staff. Just so you know come out of the rooms and bathrooms are pretty tiny, the balconies are pretty small as well so it’s a good spot if you’re looking to not stay super long or you are traveling solo"

Principe Hotel and Suites

4/10 Poor

"I couldn't get a response regarding an airport shuttle so contacted hotels.com who also failed. It was going to cost $30. My Uber cost less than $20. Clean room, but very uninviting and worn. AC was not on when I entered. It finally got too cold, but there was no way to adjust it. No coffee or water. Very nice shower, but towel rack was across the room. Only a tiny soap dish so nowhere to place your shower items. Toilet only flushed if you held the handle for a while. Hot water faucet in bathroom was broken, so tepid water only. All I needed was a place to sleep and shower between flights, so it worked for me, but it wasn't worth the money in my opinion."

Frequently asked questions

What's it like in Santa Ana?

Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Ana?

Based on our traveller data, Casco View Apartments is one of the top choices for your stay in Santa Ana. This condo is a short 8-minute walk from Avenida Balboa, and it offers an outdoor pool and in-room kitchens.

How many hotels can I expect to find in Santa Ana?

Expedia has 117 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.

If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.

What is there to do in this Panama City neighbourhood?

If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.

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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hotel República

La Manzana by Wynwood House

ART CASCO The Hotel

Casco View Apartments

Hotel Riazor

Riande Aeropuerto Hotel & Casino

Panama House Bed & Breakfast

Albrook Inn

Crowne Plaza Panama Airport by IHG

ORHO Hotel Boutique 15 Minutes from PTY Airport

Courtyard by Marriott Panama Metromall

Hotel Milan

MARINN Tropical Vibes Hotel

Ramada Plaza by Wyndham Panama Punta Pacifica

Waymore Hotel Spa & Casino

Principe Hotel and Suites

The Executive Hotel

Hotel Lisboa

Residencial & Hotel Palazzo

Compare popular hotels in Santa Ana

Where to stay in Santa Ana

Casco Viejo

Bella Vista

El Cangrejo

San Francisco

Calidonia

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Frequently asked questions