Search Hotels in Santa Ana, Panama City

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29 Dec - 30 Dec
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30 Dec - 31 Dec
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for Santa Ana hotels

Bar (on property)
Hostal La Cigarra

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is ฿787
฿866 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hostal La Cigarra
Luxury Apartment | Balcony
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (57)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Balcony
Hotel República

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ฿1,852
฿2,907 total
includes taxes & fees
19 Jan - 20 Jan 2026
La Manzana by Wynwood House
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is ฿4,543
฿4,997 total
includes taxes & fees
4 Jan - 5 Jan 2026
Room-sofa Bed Stay Rooftop Pool & Gym, A
Terrace/patio
Panama House Bed & Breakfast

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (186)
"It was a great stay in a great neighborhood with many food and beverage options, fantastic hosts and an interesting mix of people "
Canada
Brad
The price is ฿1,282
฿1,410 total
includes taxes & fees
3 Jan - 4 Jan 2026
Panama House Bed & Breakfast
Double Room | In-room safe, desk, free WiFi, bed sheets
Hotel Montreal

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 2.7 km from Santa Ana
6.0 out of 10, (398)
"Friendly staff alright room"
Canada
Ryan
Hotel Montreal
Terrace/patio
Toscana Inn

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (728)
"Very comfortable, clean, located in El Cangrejo, a lively area. Breakfast was good and saved us time for our coming trip."
United States
Alberto
Toscana Inn
Outdoor pool
Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (272)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is ฿2,638
฿2,902 total
includes taxes & fees
4 Jan - 5 Jan 2026
Ramada Panama Centro Via Argentina
Outdoor pool
MARINN PLACE Financial District

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.2 out of 10, Wonderful, (299)
"Second stay, very nice"
Canada
Xiaozhi
The price is ฿3,476
฿3,824 total
includes taxes & fees
1 Jan - 2 Jan 2026
MARINN PLACE Financial District
Outdoor pool, pool loungers
Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.2 out of 10, Very good, (212)
"We chose the wrong hotel! We thought we were staying at the crowne plaza near the airport "
United States
Carmen
The price is ฿2,917
฿3,209 total
includes taxes & fees
9 Jan - 10 Jan 2026
Crowne Plaza Panama by IHG
Outdoor spa tub
Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1001)
"Stay was ok "
United States
suhail
The price is ฿2,927
฿3,219 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hilton Garden Inn Panama City Downtown, Panama
Lobby sitting area
Hotel y Casino Central Park Panama

Hotel y Casino Central Park Panama

Hotel y Casino Central Park Panama
3.0 star property
Bethania, 5.6 km from Santa Ana
7.6 out of 10, Good, (428)
"Great service, clean, great location "
United States
EDGAR
The price is ฿1,810
฿1,991 total
includes taxes & fees
31 Dec - 1 Jan 2026
Hotel y Casino Central Park Panama
Outdoor pool, pool loungers
Gran Evenia Panama

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
El Cangrejo, 3.8 km from Santa Ana
9.2 out of 10, Wonderful, (196)
"The property was conveniently located near shops, restaurants and casinos. The food at breakfast was good. Although the pancakes could be better. "
United States
Nicole
Gran Evenia Panama
Outdoor pool, pool loungers
Hampton by Hilton Panama

Hampton by Hilton Panama

Hampton by Hilton Panama
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.8 out of 10, Good, (1002)
"The hotel is good for the price , the lobby didn’t have any air conditioning,also the rooms where clean but needed to be updated , the breakfast buffet had multiple choices and it was very good . The hotel is in great location near walking distance to restaurants and stores . I will stay again. "
United States
Yusneilys amores
The price is ฿2,290
฿2,519 total
includes taxes & fees
24 Jan - 25 Jan 2026
Hampton by Hilton Panama
Standard Apartment | Living area | Flat-screen TV
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.8 out of 10, Excellent, (485)
"Room was clean, neat great staff"
United States
Alfredo
Torres de Alba Hotel & Suites
Classic Double Room, 1 Double Bed, Non Smoking | In-room safe, desk, soundproofing, free WiFi
Hotel Acapulco

Hotel Acapulco

Hotel Acapulco
3.0 star property
Calidonia, 1.3 km from Santa Ana
7.6 out of 10, Good, (128)
"Excelente"
United States
Alejandro
The price is ฿962
฿1,058 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hotel Acapulco
Lobby
Metro Hotel Panama

Metro Hotel Panama

Metro Hotel Panama
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
7.8 out of 10, Good, (406)
"This is a a convenient hotel, located in a prime area in the city. The staff is friendly, helpful and the room is cleaned every day. "
United States
Warren
Metro Hotel Panama
Outdoor pool, pool umbrellas, pool loungers
Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG

Holiday Inn Panama Canal by IHG
3.5 star property
6 km from Santa Ana
8.6 out of 10, Excellent, (444)
"The staff was so cordial and nice "
United States
Sonny
The price is ฿3,197
฿3,516 total
includes taxes & fees
30 Jan - 31 Jan 2026
Holiday Inn Panama Canal by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"The staff were very friendly. The room was cleaned on time. They even gave me a little gift for my birthday, which I was surprised and impressed!"
Tracia 3-night trip
Posted 1 day ago
Hotel Riu Plaza Panama

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 111 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.