Search Hotels in Santa Ana, Panama City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Ana hotels

Bar (on property)
Hostal La Cigarra

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is ฿787
฿866 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hostal La Cigarra
Luxury Apartment | Balcony
Casco View Apartments

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (57)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments
Balcony
Hotel República

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República
Apartment (20) | Iron/ironing board, free WiFi, bed sheets
La Manzana by Wynwood House

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ฿1,852
฿2,907 total
includes taxes & fees
19 Jan - 20 Jan 2026
La Manzana by Wynwood House
Room, Multiple Bedrooms, Accessible, Smoking | Pool | Outdoor pool
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is ฿4,543
฿4,997 total
includes taxes & fees
12 Jan - 13 Jan 2026
Room-sofa Bed Stay Rooftop Pool & Gym, A
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4734)
"The rooms were nice and the food was great..great staff!!"
United States
Tffany
The price is ฿3,800
฿4,181 total
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Riu Plaza Panama
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG
4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very good, (2332)
"Great breakfast was included and the airport shuttle was conveniently located "
United States
Adrienne
The price is ฿3,482
฿3,830 total
includes taxes & fees
8 Jan - 9 Jan 2026
Crowne Plaza Panama Airport by IHG
2 outdoor pools, pool umbrellas, pool loungers
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.4 out of 10, Very good, (1002)
"Unbeatable location if your visit is all about the Panama Canal. "
United States
Vitaliy
The price is ฿2,480
฿2,728 total
includes taxes & fees
30 Jan - 31 Jan 2026
Radisson Hotel Panama Canal
Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1851)
"Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. "
United States
Marty
The price is ฿3,881
฿4,269 total
includes taxes & fees
1 Jan - 2 Jan 2026
Riande Aeropuerto Hotel & Casino
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport
2.5 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (40)
"It was a cool unique antique place that had modern touches. The staff was very friendly and helpful. Will definitely stay again. "
United States
Clarissa
The price is ฿3,724
฿4,834 total
includes taxes & fees
5 Jan - 6 Jan 2026
ORHO HOTEL BOUTIQUE PANAMA Airport
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1008)
"Location Location Location! Clean, safe, beautiful. Loved it!"
United States
Sharon Gobern Dorray and Jason
The price is ฿3,403
฿3,743 total
includes taxes & fees
12 Jan - 13 Jan 2026
Courtyard by Marriott Panama Metromall
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ฿6,960
฿7,656 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Meeting facility
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1003)
"Everything was clean and the staff was very cooperative."
United States
Deangelo
The price is ฿4,935
฿5,428 total
includes taxes & fees
3 Jan - 4 Jan 2026
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
Outdoor pool, pool umbrellas, pool loungers
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1130)
"The room was clean and the location was great."
United States
Wendy
The price is ฿3,429
฿3,772 total
includes taxes & fees
8 Jan - 9 Jan 2026
Ramada Plaza by Wyndham Panama Punta Pacifica
Restaurant
Hyatt Regency Panama City

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Campo Alegre, 3.3 km from Santa Ana
10.0 out of 10, Exceptional, (143)
"Great hotel fair price"
United States
Santiago
The price is ฿5,056
฿5,562 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hyatt Regency Panama City
50-inch LED TV with satellite channels
Arcadia Condo Suites

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este, 10.2 km from Santa Ana
9.4 out of 10, Exceptional, (177)
"Was a great buy. Beautiful views and spacious rooms. Great amenities. "
United States
Lesley
The price is ฿2,598
฿4,291 total
includes taxes & fees
3 Jan - 4 Jan 2026
Arcadia Condo Suites
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2148)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ฿3,350
฿3,685 total
includes taxes & fees
8 Jan - 9 Jan 2026
Plaza Paitilla Inn Hotel
Lobby
The Executive Hotel

The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1013)
"A nice hotel to stay great location"
United States
angela
The Executive Hotel
2 bars/lounges, gastropub
Riande Urban Hotel

Riande Urban Hotel

Riande Urban Hotel
3.5 star property
El Cangrejo, 3.8 km from Santa Ana
8.8 out of 10, Excellent, (1059)
"Good hotel and nice staff"
United States
Jose
The price is ฿2,610
฿2,871 total
includes taxes & fees
3 Jan - 4 Jan 2026
Riande Urban Hotel
Terrace/patio
Marriott Panama Hotel

Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
2.1 km from Santa Ana
9.0 out of 10, Wonderful, (1001)
"Great hotel and staff!"
United States
Catherine
The price is ฿4,717
฿5,189 total
includes taxes & fees
30 Jan - 31 Jan 2026
Marriott Panama Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"The staff were very friendly. The room was cleaned on time. They even gave me a little gift for my birthday, which I was surprised and impressed!"
Tracia 3-night trip
Posted 1 day ago
Hotel Riu Plaza Panama

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 111 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.