Otay Mesa Travel Guide
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tijuana Downtown Self Guided Walking Tour
฿326
per adult
100% of travellers recommend
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
฿5,008
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
฿3,776
per adult
Stand up Paddle Board Lesson on The San Diego Bay
฿835
per adult
100% of travellers recommend
Top hotels in Otay Mesa
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is ฿5,102 per night from 25 Oct to 26 Oct
฿5,102
฿7,082 total
25 Oct - 26 Oct
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.4/10 Very good! (6,359 reviews)
"Ms. Laily was absolutely wonderful! She was exceptionally friendly, welcoming, and professional. She patiently answered all my questions and went above and beyond to help us with every request. Her warm smile and kind attitude made us feel truly welcome and made our stay much more enjoyable. She ..."
Reviewed on 10 Oct 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is ฿6,928 per night from 8 Nov to 9 Nov
฿6,928
฿9,743 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (2,928 reviews)
"We paid a pretty penny for this place because of all the amenities, however, you have to pay another pretty penny just to use them."
Reviewed on 10 Oct 2026
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
The price is ฿4,661 per night from 25 Oct to 26 Oct
฿4,661
฿7,053 total
25 Oct - 26 Oct
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 outdoor pools and 5 restaurants. Our guests praise the pool and the restaurant in their ...
Handlery Hotel
950 Hotel Cir N San Diego CA
The price is ฿3,107 per night from 15 Oct to 16 Oct
฿3,107
฿3,957 total
15 Oct - 16 Oct
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and 2 bars/lounges. Our guests praise the pool and the helpful staff in their ...
8.4/10 Very good! (2,989 reviews)
"Staff was helpful and welcoming. The room was clean and quiet. Would go back again!"
Reviewed on 10 Oct 2026
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
The price is ฿5,311 per night from 9 Nov to 10 Nov
฿5,311
฿6,105 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, a marina and a health club. Our guests praise the breakfast and the restaurant in their ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is ฿5,529 per night from 3 Nov to 4 Nov
฿5,529
฿8,035 total
3 Nov - 4 Nov
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
9/10 Wonderful! (4,500 reviews)
"Excellent staff, excellent room. Great amenities. I would stay there again. I was impressed."
Reviewed on 10 Oct 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.
