Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Hotel Circle
Hotel Circle is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops and top-notch restaurants in this family-friendly area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Stand up Paddle Board Lesson on The San Diego Bay
Top hotels in Otay Mesa
Sheraton San Diego Resort
Great hotel! Enjoyed our rooms and the staff was very accommodating to our party with two small children.
Reviewed on 17 Dec 2025
Lafayette Hotel & Club
My favorite hotel in San Diego. Staff is always helpful, kind and professional. The rooms are comfortable, clean, eclectic and possibly the best minibar selection of top shelf products anywhere. The property invites you to discover and play and socialize. The bar and food programs are superb.
Reviewed on 17 Dec 2025
The DEXTRO Little Italy, BW Premier Collection
The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick.
Reviewed on 18 Dec 2025
Legacy Resort Hotel & Spa
Overall- the staff, property and room were great
Reviewed on 17 Dec 2025
Hard Rock Hotel San Diego
Wish there was a fridge and not just the "alcohol fridge", etc that they put in there (which you need to pay for).
Reviewed on 16 Dec 2025
Best Western Plus Marina Gateway Hotel
N/A
Reviewed on 17 Dec 2025
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
