Otay Mesa Travel Guide
San Diego
Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
฿1,325
per adult
Tijuana Downtown Self Guided Walking Tour
฿323
per adult
100% of travellers recommend
Tijuana: Guided City Tour with Local Food and Beer Tasting
฿3,072
per adult
From Tijuana: Valle de Guadalupe Private Winery Tour
฿4,090
per adult
100% of travellers recommend
Top hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
The price is ฿4,482 per night from 24 Sept to 25 Sept
฿4,482
฿5,098 total
24 Sept - 25 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
The price is ฿7,034 per night from 8 Sept to 9 Sept
฿7,034
฿9,816 total
8 Sept - 9 Sept
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (2,861 reviews)
"I booked a Bayview bungalow suite. The room itself was spacious with a beautiful view however, it had an awful odor like mold, mildew, and smoke. The walls were dirty. There was mold and mildew in the bathroom. I knew that there was no availability to change rooms other than pay the same and be downgraded ..."
Reviewed on 26 Aug 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
The price is ฿6,347 per night from 8 Sept to 9 Sept
฿6,347
฿9,141 total
8 Sept - 9 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges and breakfast (surcharge). Our guests praise the pool and the helpful ...
9/10 Wonderful! (2,794 reviews)
"Outstanding experience. The hotel exceeded expectations in every way. Room was gorgeous and spotless, staff so helpful, and the sushi at the Top of the Hyatt was to die for. I highly recommend!"
Reviewed on 25 Aug 2026
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
The price is ฿4,973 per night from 3 Sept to 4 Sept
฿4,973
฿6,904 total
3 Sept - 4 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
The price is ฿5,529 per night from 31 Aug to 1 Sept
฿5,529
฿7,295 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina and 2 hot tubs. Our guests praise the pool and the restaurant in their reviews. Popular attractions ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
The price is ฿5,793 per night from 31 Aug to 1 Sept
฿5,793
฿8,296 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
9/10 Wonderful! (4,239 reviews)
"At the end of the day, it’s an old hotel. But for 350+ dollars a night plus $150 a night deposit I would expect it to be nicer. For example, it shouldn’t have frayed carpet and wallpaper peeling up from the wall walls and floorboards coming up. I think it should be made clear. The pool situation ..."
Reviewed on 26 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
