Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
USS Midway Museum
Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Stand up Paddle Board Lesson on The San Diego Bay
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Top hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"The place is unique and very peaceful Food was amazing ,also the cocktails were delicious., we were very impressed with the hospitality from the staff and restaurant."
Reviewed on 26 May 2026
The Sofia Hotel
"Hotel is really nice, located in a good part of downtown. Public transit stops are nearby. I would say my only down is our fridge didn’t work. Other than that our stay was great!"
Reviewed on 26 May 2026
Manchester Grand Hyatt San Diego
"Great place to stay I recommend it"
Reviewed on 26 May 2026
Paradise Point Resort & Spa
"Beautiful Vacation spot."
Reviewed on 26 May 2026
Hard Rock Hotel San Diego
"The furniture in the room was a bit weathered but other than that the stay was great."
Reviewed on 26 May 2026
The DEXTRO Little Italy, BW Premier Collection
"Nice vibe, clean, and central location."
Reviewed on 26 May 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
