Search Hotels in Otay Mesa, San Diego
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Our top choices for Otay Mesa hotels
1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.2 out of 10, Very good, (1,872 reviews)
"Good hotel for the area, can’t go wrong with a holiday inn express."
Kuljit
The price is ฿4,377
฿4,978 total
includes taxes & fees
11 Oct - 12 Oct
2. Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.2 out of 10, Good, (1,010 reviews)
"Very quiet and friendly staff excellent breakfast"
Mia
The price is ฿3,473
฿3,951 total
includes taxes & fees
11 Oct - 12 Oct
3. Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
8.8 out of 10, Excellent, (1,378 reviews)
"Great stay"
Luis
The price is ฿3,735
฿4,249 total
includes taxes & fees
20 Sept - 21 Sept
4. Ayres Hotel San Diego South - Chula Vista
Ayres Hotel San Diego South - Chula Vista6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,066 reviews)
"We love this hotel: all the staff are very nice and helpful."
Shan Shan
The price is ฿6,338
฿6,984 total
includes taxes & fees
11 Oct - 12 Oct
5. Best Western Plus Marina Gateway Hotel
Best Western Plus Marina Gateway Hotel16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,092 reviews)
"Great place to stay, very clean and comfortable beds."
Alexander
The price is ฿5,301
฿5,842 total
includes taxes & fees
20 Sept - 21 Sept
6. La Quinta Inn by Wyndham San Diego Chula Vista
La Quinta Inn by Wyndham San Diego Chula Vista12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,733 reviews)
"Great amenities, clean rooms, staff is extremely helpful."
Sharon
The price is ฿3,384
฿3,723 total
includes taxes & fees
11 Oct - 12 Oct
7. Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South13 km from Otay Mesa
8.2 out of 10, Very good, (1,653 reviews)
"Great hotel to stay."
Katsuya
The price is ฿3,338
฿3,679 total
includes taxes & fees
11 Oct - 12 Oct
8. Holiday Inn Express San Diego South - Chula Vista by IHG
Holiday Inn Express San Diego South - Chula Vista by IHG14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,519 reviews)
"Enjoyed my stay"
Cathie
The price is ฿5,006
฿5,507 total
includes taxes & fees
20 Sept - 21 Sept
9. SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (767 reviews)
"Nice hotel"
Alfonso
The price is ฿6,198
฿6,829 total
includes taxes & fees
11 Oct - 12 Oct
10. The Rambler Hotel
The Rambler Hotel14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,203 reviews)
"Just a great place to stay!"
Tracy
The price is ฿3,841
฿4,752 total
includes taxes & fees
23 Sept - 24 Sept
11. Hercor Hotel - Urban Boutique
Hercor Hotel - Urban Boutique13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,513 reviews)
"The room was clean, and the staff was very helpful"
Mahmoud
The price is ฿3,256
฿3,588 total
includes taxes & fees
27 Sept - 28 Sept
12. Hotel Palmeras Chula Vista
Hotel Palmeras Chula Vista14.4 km from Otay Mesa
7.4 out of 10, Good, (2,322 reviews)
"Great place to stay and very convenient"
Idanesha
The price is ฿2,332
฿2,565 total
includes taxes & fees
11 Oct - 12 Oct
13. Howard Johnson by Wyndham National City/San Diego South
Howard Johnson by Wyndham National City/San Diego South18.3 km from Otay Mesa
7.4 out of 10, Good, (1,132 reviews)
"Great hotel"
Erika
The price is ฿2,458
฿2,709 total
includes taxes & fees
1 Oct - 2 Oct
14. Lamplighter Inn & Suites at SDSU
Lamplighter Inn & Suites at SDSU24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,429 reviews)
"Great stay"
Bernadette
The price is ฿4,319
฿4,869 total
includes taxes & fees
7 Oct - 8 Oct
15. Motel 6 El Cajon, CA - San Diego
Motel 6 El Cajon, CA - San Diego27 km from Otay Mesa
7.4 out of 10, Good, (1,769 reviews)
"Decent and clean stay for the price"
Melissa
The price is ฿2,152
฿2,466 total
includes taxes & fees
1 Oct - 2 Oct
16. Hampton Inn & Suites San Diego Airport Liberty Station
Hampton Inn & Suites San Diego Airport Liberty Station29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,708 reviews)
"Loved the staff and location."
David
The price is ฿5,767
฿6,629 total
includes taxes & fees
5 Oct - 6 Oct
17. Springhill Suites San Diego Mission Valley
Springhill Suites San Diego Mission Valley28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,001 reviews)
"Kind receiption, very well-managed hotel, and nice location."
Jin Soo
The price is ฿5,232
฿6,014 total
includes taxes & fees
20 Sept - 21 Sept
18. Sheraton San Diego Resort
Sheraton San Diego Resort28.1 km from Otay Mesa
8.6 out of 10, Excellent, (3,679 reviews)
"Great place"
Kathleen
The price is ฿5,561
฿8,057 total
includes taxes & fees
27 Sept - 28 Sept
19. Town and Country San Diego
Town and Country San Diego29.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,867 reviews)
"Enjoyed our stay"
Sol
The price is ฿7,374
฿9,611 total
includes taxes & fees
12 Sept - 13 Sept
20. Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,101 reviews)
"Amazing stay."
Faleoalii Iereneo
The price is ฿4,639
฿5,333 total
includes taxes & fees
23 Sept - 24 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.
Top Otay Mesa Hotel Reviews
The DEXTRO Little Italy, BW Premier Collection
10/10 Excellent
