Otay Mesa Travel Guide

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area or simply enjoy its restaurants.
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Things to do

Kayak on the San Diego Bay

Kayak on the San Diego Bay

฿657
per adult
Kayak on the San Diego Bay
Picture 3 for Activity Tijuana: Guided City Tour with Local Food and Beer Tasting

Tijuana: Guided City Tour with Local Food and Beer Tasting

฿3,762
per adult
Tijuana: Guided City Tour with Local Food and Beer Tasting
Tijuana Downtown Self Guided Walking Tour

Tijuana Downtown Self Guided Walking Tour

฿320
per adult
100% of travellers recommend
Tijuana Downtown Self Guided Walking Tour
Taco Tuesday Hop to Tijuana from San Diego

Taco Tuesday Hop to Tijuana from San Diego

฿2,727
per adult
Taco Tuesday Hop to Tijuana from San Diego
Tijuana Urban Art Walk from San Diego

Tijuana Urban Art Walk from San Diego

฿2,628
per adult
Tijuana Urban Art Walk from San Diego
Stand up Paddle Board Lesson on The San Diego Bay

Stand up Paddle Board Lesson on The San Diego Bay

฿821
per adult
100% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
See all activities in San Diego

Top hotels in Otay Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is ฿5,377 per night from 19 Jul to 20 Jul
฿5,377
฿7,396 total
19 Jul - 20 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, 3 restaurants and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
8.4/10 Very good! (6,286 reviews)
"Clean"

Reviewed on 9 Jul 2026

Wyndham San Diego Bayside
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
The price is ฿9,319 per night from 9 Aug to 10 Aug
฿9,319
฿12,478 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy free Wi-Fi, 5 outdoor pools and a full-service spa. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (2,723 reviews)
"We love the place we will go back"

Reviewed on 9 Jul 2026

Paradise Point Resort & Spa
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is ฿5,548 per night from 19 Jul to 20 Jul
฿5,548
฿8,045 total
19 Jul - 20 Jul
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free Wi-Fi, 2 restaurants and a nightclub. Our guests praise the helpful staff and the convenient parking in their reviews. ...
9/10 Wonderful! (4,015 reviews)
"Towel is beautiful. Staff was really nice. The amenities were great."

Reviewed on 10 Jul 2026

Hard Rock Hotel San Diego
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place San Diego CA
The price is ฿4,246 per night from 2 Aug to 3 Aug
฿4,246
฿4,880 total
2 Aug - 3 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8/10 Very good! (2,797 reviews)
"Free breakfast included!"

Reviewed on 9 Jul 2026

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Bahia Resort Hotel

Bahia Resort Hotel

3.5 out of 5
998 W Mission Bay Dr San Diego CA
The price is ฿8,682 per night from 9 Aug to 10 Aug
฿8,682
฿11,829 total
9 Aug - 10 Aug
includes taxes & fees
Stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge) and 24-hour room service. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (2,235 reviews)
"Beautiful landscaped well kept grounds. The rooms were a bit outdated and not super clean. We brought our concern to the front desk staff and they sent housekeeping to clean the room. The gorgeous grounds, pool, beachy area, pickle ball courts, little kids park and daily activities were enough to ..."

Reviewed on 9 Jul 2026

Bahia Resort Hotel
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
The price is ฿6,921 per night from 10 Aug to 11 Aug
฿6,921
฿7,956 total
10 Aug - 11 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Diego. Enjoy free Wi-Fi, a marina and a health club. Our guests praise the breakfast and the restaurant in their ...
9.2/10 Wonderful! (3,737 reviews)
"Truly enjoyed our stay here in San Diego! The staff is super friendly and helpful! Room was super comfortable and the restaurant was top notch!"

Reviewed on 10 Jul 2026

Bay Club Hotel & Marina
See all 4,876 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A plaza with a traditional building, benches, and a large tree.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Seaport Village are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A beach with surfers and swimmers during sunset.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A roller coaster under construction with scaffolding and a ticket booth in the foreground.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Spreckels Theater – discover Gaslamp Quarter, a destination also famous for its shopping.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Otay Mesa Travel Guide