Otay Mesa Travel Guide
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Stand up Paddle Board Lesson on The San Diego Bay
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Top hotels in Otay Mesa
Sheraton San Diego Resort
Spotless
Reviewed on 6 Jan 2026
Bay Club Hotel & Marina
Beautiful views from room 248! Great service throughout our stay from all the departments! Quiet, serenely quiet which we really enjoyed. Everything was clean, spacious, kept up and easy to navigate.
Reviewed on 6 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
The big surprise is the Saturday farmers market right around the corner—such a great location!
Reviewed on 2 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Linen service for the room, staff, and fruit-infused water.
Reviewed on 5 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
The staff was kind and courteous , the rooms were clean, well and supplied with necessities. We received free cookies upon entry, the gym, indoor pool and jacuzzi were amazing. The only surprise that was quite significant and is not mentioned in the Expedia or hotel site description is that doubletree ...
Reviewed on 5 Jan 2026
Hilton San Diego Mission Valley
The room was nice, clean, and quiet.
Reviewed on 6 Jan 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
