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Check availability on Mytilene Luxury Hotels

Tonight
29 Dec - 30 Dec
Tomorrow
30 Dec - 31 Dec
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Our top choices for Mytilene luxury hotels

Property entrance
Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (159)
"Our experience in here was so great! Staff is so kind and helpful. breakfast is the best and the location is the best 💙"
United Kingdom
Ezgi
Theofilos Paradise Boutique Hotel
Seasonal outdoor pool
Heliotrope Hotels

Heliotrope Hotels

Heliotrope Hotels
4.0 star property
Lesvos
8.6 out of 10, Excellent, (192)
"Nice and clean hotel , very big breakfast buffet, easy parking"
United States
AVRAM
The price is ฿2,791
฿3,167 total
includes taxes & fees
30 Dec - 31 Dec
Heliotrope Hotels
Outdoor dining
The Loriet

The Loriet

The Loriet
4.0 star property
Lesvos
8.4 out of 10, Very good, (76)
"Nice place, good breakfast"
United States
Emre
The price is ฿2,321
฿2,652 total
includes taxes & fees
8 Jan - 9 Jan 2026
The Loriet
Restaurant
Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.6 out of 10, Excellent, (46)
"Brand new hotel, lovely staff. "
United States
Timothy
The price is ฿3,109
฿3,552 total
includes taxes & fees
8 Jan - 9 Jan 2026
Mythical Coast Wellness Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mytilene Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Mytilene holiday?
Mytilene has some interesting things to see and do including Port of Mytilene and Mytilini Castle, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Mytilene?
Mythical Coast Wellness Retreat is a luxury hotel with 5 restaurants and 5 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Theofilos Paradise Boutique Hotel and Elysion Hotel are two other upscale options for your stay.
When can I expect good weather in Mytilene?
Planning for the weather is a good way to make your trip to Mytilene relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Mytilene is 873 mm.
What's there to see and do in Mytilene?
Take in the sights and attractions that Mytilene offers with a visit to Port of Mytilene, Mytilini Castle and Thermes Gera Hot Springs. If you have a little extra time during your trip, you might want to make a stop at Thermi Beach and Roman Aqueduct at Moria.