A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

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Our top choices for Mytilene luxury hotels

Free daily continental breakfast

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (164 reviews)
  • cleanliness
    Luxuriate in this Lesvos boutique haven where pillowtop beds meet spa indulgences, all within steps of the beach and local art.
The price is ฿5,547
฿6,457 total
includes taxes & fees
26 Jul - 27 Jul
Theofilos Paradise Boutique Hotel
Garden

Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (87 reviews)
The price is ฿4,600
฿5,420 total
includes taxes & fees
5 Aug - 6 Aug
Loriet Hotel
Seasonal outdoor pool

Heliotrope Hotels

Heliotrope Hotels
4.0 star property
Lesvos
8.6 out of 10, Excellent, (197 reviews)
The price is ฿4,777
฿5,613 total
includes taxes & fees
12 Aug - 13 Aug
Heliotrope Hotels
Terrace/patio

Elysion Hotel

Elysion Hotel
5.0 star property
Lesvos
9.2 out of 10, Wonderful, (48 reviews)
  • cleanliness
    Experience tranquil luxury and refined comfort at this 5-star seaside retreat with outdoor tennis courts and multiple dining options.
The price is ฿5,767
฿7,837 total
includes taxes & fees
17 Jul - 18 Jul
Elysion Hotel
Exterior

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.8 out of 10, Excellent, (50 reviews)
  • cleanliness
    Seaside luxury awaits at this Greek retreat, where beachfront bliss meets wellness indulgence with 3 indoor pools and a full-service spa.
The price is ฿4,709
฿5,729 total
includes taxes & fees
27 Jul - 28 Jul
Mythical Coast Wellness Retreat
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mytilene Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Mytilene holiday?
Mytilene has some interesting things to see and do including Port of Mytilene and Mytilini Castle, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Mytilene?
Mythical Coast Wellness Retreat is a luxury hotel with 5 restaurants and 5 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Theofilos Paradise Boutique Hotel and Elysion Hotel are two other upscale options for your stay.
When can I expect good weather in Mytilene?
Planning for the weather is a good way to make your trip to Mytilene relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Mytilene is 873 mm.
What's there to see and do in Mytilene?
Take in the sights and attractions that Mytilene offers with a visit to Port of Mytilene, Mytilini Castle and Teriade Museum. If you have a little extra time during your trip, you might want to make a stop at Roman Aqueduct at Moria and Museum of the Memorial of the Refugees of 1922.