A historic building with ornate architecture, a central staircase, and lush garden landscaping.

Search Hotels in Medical Center Area, Boston

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
11 Sep - 13 Sep
Next weekend
18 Sep - 20 Sep

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Medical Center Area hotels

A hotel with a prominent sign reading "The Inn."

1. The Inn at Longwood Medical

The Inn at Longwood Medical
3.5 star property
Medical Center Area
8.4 out of 10, Very good, (1,000 reviews)
"Ideal location, with parking garage. Nice staff and clean rooms."
United States
Jennifer
The price is ฿10,632
฿13,339 total
includes taxes & fees
11 Sept - 12 Sept
The Inn at Longwood Medical
A modern hotel room with a geometric patterned floor, a brown leather sofa, a flat-screen TV mounted on the wall, and a small table with a lamp.

2. Arcadian Hotel

Arcadian Hotel
3.5 star property
1.2 km from Medical Center Area
8.2 out of 10, Very good, (4,412 reviews)
"Great to stay a night or two. Location was amazing walking distance to explore and even get food or shop."
United States
Lloyd
The price is ฿6,016
฿7,823 total
includes taxes & fees
13 Sept - 14 Sept
Arcadian Hotel
A hotel with a pool area, multiple rooms with beds, and a view of the pool.

3. The Verb Hotel

The Verb Hotel
3.5 star property
0.9 km from Medical Center Area
9.6 out of 10, Exceptional, (2,119 reviews)
"Amazing absolutely unique place to stay, will stay again and again."
United States
Heather
The price is ฿4,709
฿7,016 total
includes taxes & fees
20 Sept - 21 Sept
The Verb Hotel
An outdoor seating area with tables and chairs, a bar, and a view of Fenway Park.

4. Hotel Commonwealth

Hotel Commonwealth
4.5 star property
Fenway–Kenmore, 1.3 km from Medical Center Area
9.4 out of 10, Exceptional, (2,302 reviews)
"Great hotel in a wonderful location."
United States
Lissa
The price is ฿8,363
฿11,272 total
includes taxes & fees
20 Sept - 21 Sept
Hotel Commonwealth
An outdoor seating area with a fire pit, sofas, and chairs.

5. Hyatt Place Boston/Seaport District

Hyatt Place Boston/Seaport District
3.0 star property
Seaport District, 5.6 km from Medical Center Area
9.6 out of 10, Exceptional, (2,415 reviews)
"Great hotel in a great location lovely property will definitely stay again"
United Kingdom
Adam
The price is ฿8,522
฿9,924 total
includes taxes & fees
20 Sept - 21 Sept
Hyatt Place Boston/Seaport District
A modern living room with a fireplace, leather sofas, a glass coffee table, and a framed picture on the wall.

6. Residence Inn by Marriott Boston Downtown / South End

Residence Inn by Marriott Boston Downtown / South End
3.0 star property
1.9 km from Medical Center Area
8.8 out of 10, Excellent, (1,004 reviews)
"It's a great place to stay, very clean and nice."
United States
Marvin Alonzo
The price is ฿7,524
฿8,762 total
includes taxes & fees
20 Sept - 21 Sept
Residence Inn by Marriott Boston Downtown / South End
A room with a large window overlooking a historic building with a dome.

7. The Midtown Hotel MOD Collection by Sonesta

The Midtown Hotel MOD Collection by Sonesta
3.0 star property
Prudential - St. Botolph, 1.8 km from Medical Center Area
8.0 out of 10, Very good, (1,045 reviews)
"Perfect hotel for the price. Conveniently located with comfortable beds."
United States
Jason
The price is ฿7,206
฿8,392 total
includes taxes & fees
13 Sept - 14 Sept
The Midtown Hotel MOD Collection by Sonesta
A high-rise building with a distinctive dome structure and reflective glass facade, surrounded by other tall buildings in a cityscape.

8. Sheraton Boston, a Marriott Hotel

Sheraton Boston, a Marriott Hotel
4.0 star property
Prudential - St. Botolph, 1.8 km from Medical Center Area
8.8 out of 10, Excellent, (1,920 reviews)
"We loved the location! It was close to everything and all the amenities were excellent!"
United States
Ioulia
The price is ฿7,865
฿9,158 total
includes taxes & fees
20 Sept - 21 Sept
Sheraton Boston, a Marriott Hotel
A modern indoor pool with clear blue water, surrounded by lounge chairs and a city view through large windows.

9. Boston Marriott Copley Place

Boston Marriott Copley Place
4.0 star property
Prudential - St. Botolph, 2.2 km from Medical Center Area
9.4 out of 10, Exceptional, (1,850 reviews)
"Great location!"
United States
Beatriz
The price is ฿9,971
฿12,952 total
includes taxes & fees
20 Sept - 21 Sept
Boston Marriott Copley Place
A rooftop pool area with lounge chairs and umbrellas, overlooking a cityscape.

10. The Colonnade Hotel Back Bay

The Colonnade Hotel Back Bay
4.0 star property
Prudential - St. Botolph, 2 km from Medical Center Area
9.2 out of 10, Wonderful, (2,466 reviews)
"Great location and super helpful staff!"
United States
Lee Anne
The price is ฿10,860
฿13,796 total
includes taxes & fees
18 Sept - 19 Sept
The Colonnade Hotel Back Bay
A modern hotel with a prominent Hampton Inn sign, featuring a multi-story structure with a central courtyard and a landscaped area.

11. Hampton by Hilton at the Boston Seaport District

Hampton by Hilton at the Boston Seaport District
3.0 star property
Seaport District, 5.4 km from Medical Center Area
9.2 out of 10, Wonderful, (2,881 reviews)
"Very good place to stay."
United States
Darin
The price is ฿6,781
฿7,897 total
includes taxes & fees
13 Sept - 14 Sept
Hampton by Hilton at the Boston Seaport District
A buffet area with various food items, a coffee station, and a seating area in the background.

12. Hampton Inn & Suites Boston Crosstown Center

Hampton Inn & Suites Boston Crosstown Center
3.0 star property
2.6 km from Medical Center Area
8.0 out of 10, Very good, (1,843 reviews)
"Great stay"
United States
Amanda
The price is ฿6,024
฿7,015 total
includes taxes & fees
13 Sept - 14 Sept
Hampton Inn & Suites Boston Crosstown Center
A hotel room with a large bed, a sofa, a desk, and a view of a cityscape with a bridge.

13. Courtyard by Marriott Boston Downtown/North Station

Courtyard by Marriott Boston Downtown/North Station
3.0 star property
West End, 4.7 km from Medical Center Area
9.4 out of 10, Exceptional, (1,469 reviews)
"Excellent location , grate hotel"
United States
Jennifer
The price is ฿6,964
฿8,110 total
includes taxes & fees
13 Sept - 14 Sept
Courtyard by Marriott Boston Downtown/North Station
A spacious hotel lobby with a high ceiling, large windows, and a blue carpet.

14. Embassy Suites Boston Logan Airport

Embassy Suites Boston Logan Airport
3.5 star property
6.9 km from Medical Center Area
8.8 out of 10, Excellent, (2,615 reviews)
"Great stay, close to the airport."
United States
Maria Criselda
The price is ฿8,784
฿10,229 total
includes taxes & fees
13 Sept - 14 Sept
Embassy Suites Boston Logan Airport
A cityscape with a prominent hotel featuring a classic facade, a modern high-rise, and a historic building with arched windows.

15. The Westin Copley Place, Boston, a Marriott Hotel

The Westin Copley Place, Boston, a Marriott Hotel
4.0 star property
Prudential - St. Botolph, 2.4 km from Medical Center Area
9.2 out of 10, Wonderful, (1,504 reviews)
"Great stay"
United States
Tara
The price is ฿9,714
฿12,653 total
includes taxes & fees
13 Sept - 14 Sept
The Westin Copley Place, Boston, a Marriott Hotel
A bar area with a city view, bar stools, and a bar counter.

16. citizenM Boston Back Bay

citizenM Boston Back Bay
4.0 star property
1.6 km from Medical Center Area
9.4 out of 10, Exceptional, (3,149 reviews)
"Very nice hotel definitely would stay again"
United States
Adrian
The price is ฿5,232
฿6,093 total
includes taxes & fees
13 Sept - 14 Sept
citizenM Boston Back Bay
A high-rise hotel with multiple floors, large windows, and a waterfront view.

17. Seaport Hotel Boston

Seaport Hotel Boston
4.0 star property
Seaport District, 5.3 km from Medical Center Area
9.6 out of 10, Exceptional, (4,995 reviews)
"Nice location and good accommodations."
United States
Cordell
The price is ฿6,548
฿8,748 total
includes taxes & fees
11 Sept - 12 Sept
Seaport Hotel Boston
A restaurant named "SWEENEYS ON BOYLTON" with outdoor seating and a black facade.

18. The Lenox Hotel Boston

The Lenox Hotel Boston
4.5 star property
Prudential - St. Botolph, 2.3 km from Medical Center Area
9.6 out of 10, Exceptional, (1,727 reviews)
"Excellent hotel! Looking forward to staying there again."
United States
Michelle
The price is ฿12,883
฿15,002 total
includes taxes & fees
13 Sept - 14 Sept
The Lenox Hotel Boston
A modern living room with a sectional sofa, a round coffee table, and a chandelier.

19. Hyatt Regency Boston

Hyatt Regency Boston
4.0 star property
Downtown Crossing, 3.9 km from Medical Center Area
9.2 out of 10, Wonderful, (2,239 reviews)
"Hotel was very nice and in a great location."
Canada
Chris
The price is ฿6,548
฿8,777 total
includes taxes & fees
13 Sept - 14 Sept
Hyatt Regency Boston
A grand entrance with an arched doorway, two large potted plants, and ornate lanterns.

20. Hotel AKA Back Bay

Hotel AKA Back Bay
4.5 star property
Prudential - St. Botolph, 2.8 km from Medical Center Area
9.4 out of 10, Exceptional, (1,359 reviews)
"Great, great place"
United States
Justin
The price is ฿9,675
฿12,609 total
includes taxes & fees
12 Sept - 13 Sept
Hotel AKA Back Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Medical Center Area

Find the best Medical Center Area areas for the activities you enjoy most.
A nighttime street scene with illuminated trees, a market stall, and historic buildings.

Downtown Boston

The heart of America’s revolutionary history lies in the center of this city. Uncover the story of the nation and enjoy excellent arts and dining venues.

A historic church with a large central tower and multiple spires, surrounded by modern buildings and a public square with people and greenery.

Back Bay

Parisian boulevards and elegant brownstones conjure a truly romantic atmosphere, perfect for strolling and window shopping.

A large, illuminated ship docked at a pier with fireworks in the background.

Seaport District

Join excited crowds enjoying harbor-side views, Revolutionary War-era landmarks, as well as superb restaurants and museums along this thriving waterfront.

A narrow alley with brick buildings, green ivy, and street lamps.

Beacon Hill

Lose yourself in the charming streetscapes, historic buildings and village-like atmosphere of Boston’s oldest and wealthiest suburbs.

A statue of a man on horseback in a park with trees, a clock tower, and brick buildings in the background.

North End

The ample dining options and captivating waterfront views are just a few popular features of the neighbourhood. Make a stop by Boston Harbor or New England Aquarium while you're visiting, and jump aboard the metro at Aquarium to get around town.

Top Medical Center Area Hotel Reviews

Omni Boston Hotel at the Seaport

Omni Boston Hotel at the Seaport

10/10 Excellent
"Liz at front desk was great. Team members were friendly."
Kevin 1-night trip
Posted 1 hour ago
Omni Boston Hotel at the Seaport

Frequently asked questions

What's it like in Medical Center Area?
Guests are sure to enjoy their time checking out all that Boston's Medical Center Area neighbourhood has to offer. Make sure that you visit Isabella Stewart Gardner Museum and Joseph B. Martin Conference Center as part of your Medical Center Area travel plans.
What's the best accommodation in Medical Center Area?
Based on Expedia customer reviews, The Inn at Longwood Medical is the highest ranked property in Medical Center Area. This hotel is a short 1-minute walk from Boston Children's Hospital, and it offers a restaurant and a fitness centre.
How many hotels will I be able to find in Medical Center Area?
When you want to put your feet up after a day of exploring the sights in Boston, you can choose from 14 Expedia hotels and other accommodation options in Medical Center Area.
If I need to cancel my hotel reservation in Medical Center Area, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to view the best deals in Medical Center Area.
What can I see and do in this Boston neighbourhood?
Sights like Isabella Stewart Gardner Museum and Warren Anatomical Museum can be part of your cultural tour of Medical Center Area. A visit to Joseph B. Martin Conference Center is also worth the trip while you're discovering the neighbourhood. Don't miss favourite places to visit in the surrounding area, such as Fenway Park, Copley Square and Harvard Square. TD Garden and Faneuil Hall Marketplace are also worth a visit when you're out sightseeing in Boston.
How can I get around Medical Center Area and the greater Boston area?
If you want to see more of the city, Longwood Medical Area Station is the closest metro stop. Others nearby include Brigham Circle Station and Museum of Fine Arts Station.