Main Street

Liam Maguire's Irish Pub & Restaurant with outdoor seating and flower pots.
A restaurant named Martha's with outdoor seating and potted plants.
A large cruise ship on a calm sea with a person sitting on a bench in the foreground.
A marina with several boats docked, a person rowing a boat, and a house in the background.
A large house by the water with several boats.

Top Hotel Deals

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod

4 out of 5
1225 Iyannough Rd Hyannis MA
Margaritaville Resort Cape Cod
Craigville Beach Inn

Craigville Beach Inn

2 out of 5
1338 Craigville Beach Rd Centerville MA
Craigville Beach Inn
The Ocean View

The Ocean View

2.5 out of 5
966 Craigville Beach Road Centerville MA
The Ocean View
Captain David Kelley House Bed & Breakfast

Captain David Kelley House Bed & Breakfast

3.5 out of 5
539 Main Street Centerville MA
Captain David Kelley House Bed & Breakfast
Hyannis Harbor Hotel

Hyannis Harbor Hotel

3.5 out of 5
213 Ocean St Hyannis MA
Hyannis Harbor Hotel
Holiday Inn Express Hyannis Cape Cod by IHG

Holiday Inn Express Hyannis Cape Cod by IHG

2.5 out of 5
1470 Iyannough Road Hyannis MA
Holiday Inn Express Hyannis Cape Cod by IHG
Hyannis Plaza Hotel

Hyannis Plaza Hotel

2.5 out of 5
662 Main Street Hyannis MA
Hyannis Plaza Hotel
Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection

4 out of 5
135 Route 28 West Yarmouth MA
Uncommoner Hotel by Reverie Boutique Collection
Bayside Resort Hotel

Bayside Resort Hotel

3 out of 5
225 Route 28 West Yarmouth MA
Bayside Resort Hotel
See all 5,925 properties in Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.