Santo Spirito Travel Guide
Florence
Visit Santo Spirito
Stay near popular Santo Spirito attractions
Things to do
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
City Sightseeing Florence Hop-on Hop-off Bus Tour
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Florence: Reserved Entrance Ticket to the Medici Chapel
Small-Group Wine Tasting Experience in the Tuscan Countryside
Accademia timed-entry Ticket with Instant Delivery & Priority Access
Top hotels in Santo Spirito
Hotel Horto Convento
"Super beautiful location off the beaten path, but easily walkable into the center of town! Wonderful, clean, professional and elegant!"
Reviewed on 20 Jul 2026
La Torre Del Cestello
"Very nice and large room.host at reception always very nice. Could use a little update.The walls repainted,fridge freezer not working and our sink was clogged. Location was 10 out of 10"
Reviewed on 20 Jul 2026
UNA Hotels Vittoria Firenze
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
Reviewed on 12 May 2026
Foresteria Valdese di Firenze - Casa per Ferie
"Conveniently located. Monica was super helpful. I would definitely stay there again."
Reviewed on 20 Jul 2026
Palazzo Mannaioni Suites
"Very clean room and wonderful staff."
Reviewed on 20 Jul 2026
Torre di Bellosguardo
"This was by far the best hotel I have ever stayed at, as someone who travels solo often sometimes you are just looking for some peace and not having to do everything on your own. I am in awe of the property. If you are looking for privacy, story book views, and gardens this is the place to be. The ..."
Reviewed on 29 Oct 2025
Where to stay in Santo Spirito
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Piazza della Signoria are major draws. Catch the metro at UnitĆ Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza del Duomo while you're exploring the neighbourhood.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Signoria and Cathedral of Santa Maria del Fiore are top sights worth seeing.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
