Santo Spirito Travel Guide
Florence
Visit Santo Spirito
Stay near popular Santo Spirito attractions
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Florence: Reserved Entrance Ticket to the Medici Chapel
Florence: Reserved Entry Ticket to Bargello Museum
Accademia timed-entry Ticket with Instant Delivery & Priority Access
Top hotels in Santo Spirito
Hotel Horto Convento
"I so love this hotel. I have been there 4 years ago. Its in an incredible part of town, quiet quaint full of artists shops. There is even an adorable ginger cat that hung out in the grass in front. We came back again now and I plan to be back as well."
Reviewed on 9 Aug 2026
La Torre Del Cestello
"I had a wonderful stay. The room was clean, spacious and comfortable. The location was convenient and a quick walk to the metro, attractions and many dining options. The room provided many extra amenities such as water, coffee and bathroom slippers. The air conditioning unit in my room was very weak ..."
Reviewed on 4 Aug 2026
UNA Hotels Vittoria Firenze
Foresteria Valdese di Firenze - Casa per Ferie
"Conveniently located. Monica was super helpful. I would definitely stay there again."
Reviewed on 20 Jul 2026
Palazzo Mannaioni Suites
"We loved this apartment! The staff were friendly and helpful, suggesting places to eat and ordering taxis to the train station. The apartment was perfect for what we wanted - would highly recommend and would absolutely stay here again"
Reviewed on 5 Aug 2026
Hostel Santa Monaca
"No"
Reviewed on 30 Jul 2026
Where to stay in Santo Spirito
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Piazza del Duomo are major draws. Catch the metro at UnitĆ Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Piazza del Duomo while you're exploring the neighbourhood.
San Giovanni
If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
Santa Croce
Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.
