Search Hotels in Zona 21, Guatemala City

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14 Dec - 15 Dec
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15 Dec - 16 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Zona 21 hotels

Outdoor banquet area
Barceló Guatemala City

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
Zona 9, 6.1 km from Zona 21
9.2 out of 10, Wonderful, (3116)
"Friendly staff , wonderful beds. Breakfast was great and large variety of foods. "
United States
Parker
The price is ฿2,118
฿2,584 total
includes taxes & fees
6 Jan - 7 Jan 2026
Barceló Guatemala City
Front of property
Why Not Hotel

Why Not Hotel

Why Not Hotel
3.0 star property
20.3 km from Zona 21
8.4 out of 10, Very good, (146)
"Great hotel! Absolutely recommend it. "
United States
Jorge
The price is ฿1,331
฿1,624 total
includes taxes & fees
15 Jan - 16 Jan 2026
Why Not Hotel
Family Quadruple Room | Free WiFi, bed sheets
Hostal Donde Regina

Hostal Donde Regina

Hostal Donde Regina
3.0 star property
Zona 13, 4.4 km from Zona 21
9.2 out of 10, Wonderful, (168)
"Spotless room and good staff service"
United States
Christian
The price is ฿1,518
฿1,852 total
includes taxes & fees
20 Dec - 21 Dec
Hostal Donde Regina
Garden
Good Hotel Guatemala City

Good Hotel Guatemala City

Good Hotel Guatemala City
3.0 star property
Zona 4, 8.4 km from Zona 21
9.4 out of 10, Exceptional, (242)
"Great place to stay in the city"
United States
Cesar
The price is ฿3,032
฿3,699 total
includes taxes & fees
16 Dec - 17 Dec
Good Hotel Guatemala City
Exterior
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

Wyndham Garden Guatemala City
4.0 star property
Zona 10, 6.6 km from Zona 21
9.2 out of 10, Wonderful, (1617)
"Location and hotel is amazing and the staff is very helpful"
United States
Martha
The price is ฿2,839
฿3,464 total
includes taxes & fees
24 Dec - 25 Dec
Wyndham Garden Guatemala City
Reception
In & Out Hotel

In & Out Hotel

In & Out Hotel
3.0 star property
Zona 13, 4.4 km from Zona 21
8.6 out of 10, Excellent, (803)
"We needed a place close to the airport for just one night, preferably with transport to the airport included. In & Out was a good fit. It is not a fancy place, but is clean and comfortable and they provide a good breakfast menu."
United States
Cynthia
In & Out Hotel
Exterior
Hotel Panchoy

Hotel Panchoy

Hotel Panchoy
3.0 star property
19.7 km from Zona 21
8.4 out of 10, Very good, (274)
"Nice staff and good location "
United States
Luis
The price is ฿1,830
฿2,232 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Panchoy
Comfort Quadruple Room | Living area
Casa Quetzalli Los Nazarenos

Casa Quetzalli Los Nazarenos

Casa Quetzalli Los Nazarenos
2.0 star property
20.8 km from Zona 21
9.4 out of 10, Exceptional, (24)
"The room was very clean and large. I stayed in room 1 and the car noises were very present but after a day of hiking it was not hard to fall asleep."
United States
Tina
The price is ฿818
฿998 total
includes taxes & fees
16 Dec - 17 Dec
Casa Quetzalli Los Nazarenos
Interior entrance
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
Zona 11, 8.3 km from Zona 21
9.0 out of 10, Wonderful, (1005)
"Very nice hotel"
United States
Jeudy
The price is ฿3,382
฿4,126 total
includes taxes & fees
4 Jan - 5 Jan 2026
Tikal Futura Hotel & Convention Center
Outdoor pool
Holiday Inn Guatemala City by IHG

Holiday Inn Guatemala City by IHG

Holiday Inn Guatemala City by IHG
3.5 star property
Zona 10, 6.5 km from Zona 21
9.2 out of 10, Wonderful, (1002)
"Best Holiday Inn I've ever stayed in! Really nice. Good restaurant, nice staff. Be patient with the hot water. It'll arrive in a minute or two, and be good thereafter."
United States
Alan
The price is ฿2,902
฿3,541 total
includes taxes & fees
23 Dec - 24 Dec
Holiday Inn Guatemala City by IHG
Economy Room | 1 bedroom, free WiFi
Casa 96

Casa 96

Casa 96
3.0 star property
Zona 13, 4.6 km from Zona 21
9.0 out of 10, Wonderful, (325)
"Clean room, very helpful staff and very convenient for the airport "
United States
Ashley
The price is ฿1,529
฿1,865 total
includes taxes & fees
14 Jan - 15 Jan 2026
Casa 96
Indoor pool, outdoor pool, pool loungers
Kawilal Hotel

Kawilal Hotel

Kawilal Hotel
3.5 star property
10.3 km from Zona 21
9.0 out of 10, Wonderful, (132)
"Beautiful pool and spa with thermal water! Only hotel guests are allowed to have use of the installations. The massage was amazing! I would love to go back "
United States
Ana
The price is ฿3,407
฿4,157 total
includes taxes & fees
6 Jan - 7 Jan 2026
Kawilal Hotel
Restaurant
Villas Santander - Deluxe Stay

Villas Santander - Deluxe Stay

Villas Santander - Deluxe Stay
3.0 star property
Zona 10, 6.7 km from Zona 21
7.4 out of 10, Good, (220)
"The balcony view was a little scenic. Enjoyed how clean the rooms were "
United States
Rosa
The price is ฿1,299
฿1,584 total
includes taxes & fees
16 Dec - 17 Dec
Villas Santander - Deluxe Stay
Classic Quadruple Room, Multiple Beds, Non Smoking | Iron/ironing board, free WiFi, bed sheets
Aurora Express

Aurora Express

Aurora Express
3.5 star property
Zona 13, 3.6 km from Zona 21
9.0 out of 10, Wonderful, (579)
"This is my 3rd time booking this place and is amazing very close to the airport, very spacious and clean. "
United States
Luis Pablo
The price is ฿1,675
฿2,044 total
includes taxes & fees
13 Jan - 14 Jan 2026
Aurora Express
Breakfast, lunch, dinner served; international cuisine, garden views
Clarion Suites Guatemala City

Clarion Suites Guatemala City

Clarion Suites Guatemala City
4.0 star property
Zona 10, 6.4 km from Zona 21
9.0 out of 10, Wonderful, (1011)
"Loved the stay here!"
United States
Nora
The price is ฿3,180
฿3,880 total
includes taxes & fees
25 Dec - 26 Dec
Clarion Suites Guatemala City
Interior
Hotel Don Felipe Airport

Hotel Don Felipe Airport

Hotel Don Felipe Airport
2.0 star property
Zona 13, 3.8 km from Zona 21
8.2 out of 10, Very good, (22)
"Close to the airport "
United States
Alejandro
Hotel Don Felipe Airport
Hallway
Hotel Casa Antigua

Hotel Casa Antigua

Hotel Casa Antigua
3.0 star property
20.2 km from Zona 21
8.2 out of 10, Very good, (546)
"The room was very good and the staff very nice"
United States
Carmen
The price is ฿2,650
฿3,233 total
includes taxes & fees
25 Dec - 26 Dec
Hotel Casa Antigua
Reception
Hotel La Sin Ventura

Hotel La Sin Ventura

Hotel La Sin Ventura
2.0 star property
20.2 km from Zona 21
9.0 out of 10, Wonderful, (142)
"Really glad we stayed here. This hotel has the best staff ever. Perfect location. "
United States
Greg
Hotel La Sin Ventura
4 restaurants, breakfast, lunch, dinner served; international cuisine
InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG
5.0 star property
Zona 10, 6.4 km from Zona 21
9.2 out of 10, Wonderful, (1001)
"Very friendly staff and clean room"
United States
Julia
The price is ฿4,259
฿5,581 total
includes taxes & fees
20 Dec - 21 Dec
InterContinental Real Guatemala by IHG
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
20.2 km from Zona 21
9.4 out of 10, Exceptional, (646)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is ฿4,574
฿6,350 total
includes taxes & fees
29 Dec - 30 Dec
Hotel Posada de Don Rodrigo Antigua
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Zona 21

Find the best Zona 21 areas for the activities you enjoy most.

Zona 10

Zona 10 is known for its abundant dining options, and you can plan a trip to Oakland Mall and Plaza Fontabella Shopping Center while you're in town.

Zona 1

Zona 1 is noteworthy for its historical sites, and you can make a stop at top attractions like Guatemala City Hall and Central Market.

Zona 9

Travellers come to Zona 9 for its abundant dining options, and you can see top attractions like Avenida La Reforma and Torre del Reformador while you're in town.

Zona 13

Zona 13 is noteworthy for its gardens, and you can make a stop at top attractions like Avenida Las Américas and El Obelisco.

Zona 16

Travellers like the festivals in Zona 16, and Paseo Cayala is a top attraction you might want to visit.

Top Zona 21 Hotel Reviews

The Westin Camino Real, Guatemala

The Westin Camino Real, Guatemala

10/10 Excellent
"Very friendly staff, clean room, great restaurants!"
Adam 1-night trip
Posted 10 days ago
The Westin Camino Real, Guatemala

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Frequently asked questions

What's it like in Zona 21?
Travellers are sure to enjoy a stay in Guatemala City's Zona 21 neighbourhood.
If I need to cancel my hotel reservation in Zona 21, will I receive a refund?
Yes, most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in Zona 21.
What is there to do around this Guatemala City neighbourhood?
Mundo Petapa, Guatemalan Exporters Association and Parque Las Américas are just a few of the places to visit in and around Zona 21. When you're sightseeing in Guatemala City, Embassy of Peru and Avenida Las Américas are also worth a stop.