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The current price is ฿4,833
฿5,819 total
includes taxes & fees
18 Aug - 19 Aug

Room options

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Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(118 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(36 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(8 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed
  • Free Wi-Fi

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

9.0 out of 10
Wonderful
(2 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | In-room safe, desk, laptop workspace, blackout curtains

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | In-room safe, desk, laptop workspace, blackout curtains

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed
  • Free Wi-Fi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed
  • Free Wi-Fi

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About the area

Located in St. Louis, 21C Museum Hotel St Louis is in the city centre. St. Louis Union Station and Gateway Arch are notable landmarks, and the area's natural beauty can be seen at Mississippi River and Forest Park. Check out an event or a game at Dome at America’s Center, and consider making time for St. Louis Zoo, a top attraction not to be missed. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • A city street with a red car, a blue fire hydrant, and a building with a spire.
    Washington Avenue Historic District
    2 min walk - 0.2 km
  • A tightrope walker balancing on a wire between buildings.
    City Museum
    5 min walk - 0.4 km
  • A historic building with a clock tower and red-roofed structures.
    St. Louis Union Station
    8 min walk - 0.7 km
  • A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.
    Enterprise Center
    8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station
    11 min walk - 1.0 km

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • Lambert-St. Louis International Airport (STL)
    24 min drive

Restaurants

  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Rosalita's Cantina
    6 min walk
  • Medina Grill
    5 min walk
  • City Museum Rooftop Cafe
    5 min walk
  • Good Press
    1 min walk

About this property

21C Museum Hotel St Louis

  • Luxury hotel near City Museum
  • A short walk from St. Louis Union Station and Enterprise Center, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business centre, guests can connect to free in-room WiFi.
  • You'll also enjoy the following perks during your stay:
    • An indoor pool
    • Cooked-to-order breakfast (surcharge), valet parking (surcharge) and a lift
    • A billiards/pool table, meeting rooms and ATM/banking services
    • Smoke-free property, a vending machine and a banquet hall
    • Guest reviews say great things about the dining options, pool and helpful staff
  • Room features
  • All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks such as free WiFi and desk chairs. Guest reviews highly rate the cleanliness rooms at the property.
  • More amenities include:
    • Free toiletries and hairdryers
    • Flat-screen TVs with premium channels
    • Wardrobes/cupboards, heating and daily housekeeping

Awards and affiliations

  • Eco-certified property
  • This property participates in Green Key Global – a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available

Payment types at the property

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 21 Jul 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 18 Aug 2026 start from ฿4,833, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at 21C Museum Hotel St Louis ?

Valet parking is available for USD 50 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Checkout is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

Have a question?

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Reviews

Reviews

9.0

Wonderful

9.2

Cleanliness

9.0

Amenities

9.0

Staff & service

9.2

Property conditions & facilities
Rating 10 - Excellent. 1398 out of 1982 reviews
Rating 8 - Good. 302 out of 1982 reviews
Rating 6 - Okay. 144 out of 1982 reviews
Rating 4 - Poor. 64 out of 1982 reviews
Rating 2 - Terrible. 74 out of 1982 reviews

Reviews

Verified

10/10 Excellent

Joe

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Gretchen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Has to be one of the most beautiful hotels we have ever stayed at. All of the employees were amazing. And the best amenities. Pool, shuffle board, pool table and the 2nd floor is a beautiful art museum. Rooms were clean with plenty of room
Stayed 1 night in Jul 2026
Verified

10/10 Excellent

Katrina

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice place great location
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Michele

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
the hotel was well appointed and staff very attentive.
Stayed 1 night in Jun 2026
Verified

10/10 Excellent

Matthew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice classic clean hotel
Stayed 1 night in May 2026
Verified

10/10 Excellent

Evan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property, great food, great drinks, great staff. I love a 21C
Stayed 1 night in Jun 2026
Verified

10/10 Excellent

Lauren

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was clean and the bathroom was great! The shower was the absolute best!! The property was very nice, there was plenty to do in the hotel itself and was close by to other activities in St. Louis.
Stayed 3 nights in May 2026
Verified

10/10 Excellent

ADIS

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice room size and clean
Stayed 1 night in Jun 2026
Verified

10/10 Excellent

Porsha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I loved this hotel! It truly felt like a nice getaway and was absolutely beautiful! The Staff was very nice and professional. We ate breakfast where the coffee shop was and the breakfast burrito was so good! We will be back!
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms were clean and common areas well maintained. Breakfast was the best and the staff were all helpful and very kind to all guests. It was the best stay I've had in a hotel.
Stayed 1 night in May 2026
Verified

10/10 Excellent

Erika

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel. It has multiple restaurants and an art gallery along with an Olympic sized pool and Jacuzzi. I travelled with teenage boys and we thoroughly enjoyed our stay. Very unique property.
Stayed 2 nights in May 2026
Verified

10/10 Excellent

Emily

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was an experience the minute you walk in the door. Very positive and artsy. Comfy beds and great smelling, clean rooms. Great experience!
Stayed 1 night in Jun 2026
Verified

10/10 Excellent

Leslie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I loved my stay, but evidently this is in a relatively rough part of town. I didn’t realise that when I booked it so it’s probably not very good in terms of walking around, but I was just there for one quick overnight stay so it was lovely. In addition the restaurant was absolutely fantastic and worth going to! Quite a crowd and an amazing menu.
Stayed 1 night in Jun 2026
Verified

10/10 Excellent

Brigitte

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
As a first time guest, I absolutely loved the entire experience. Being able to view the art on display, enjoy the arty decor throughout the hotel was a pleasure. We stayed in Deluxe King room.The room was nice and quiet, clean, welcoming and the shower stall is spacious.
Stayed 3 nights in May 2026
Verified

10/10 Excellent

Quintin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We loved how welcoming and accommodating the staff was throughout our stay. Upon arrival, our room was not as clean as we expected, but after notifying the concierge, the issue was addressed promptly and the room was cleaned to perfection. We enjoyed breakfast, lunch, and dinner at the hotel, and every meal was excellent. Overall, I would rate our experience a 10 out of 10 and would highly recommend this hotel to anyone looking for outstanding service and hospitality.
Stayed 2 nights in Jun 2026
Verified

8/10 Good

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, crisp and comfortable youthful vibe. The art exhibition was stunning. The staff are so friendly and helpful. Both the cafe and restaurant had great food and drinks. Highly recommend. The security hold is $400 FYI
Stayed 4 nights in Jun 2026
Verified

10/10 Excellent

Salvatore

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room are clean
Stayed 1 night in May 2026
Verified

10/10 Excellent

Jared

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
ABSOLUTELY PERFECT STAY! We loved the bar downstairs and the museum exhibit was perfect. We love the room, the game room, and the staff 10/10 recommend and will be staying again
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Absolutely beautiful, amazing breakfast, comfy bed!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Heather

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean, staff was friendly and knowledgeable
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

Chad

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A fantastic stay. Great breakfast and excellent pool area. Would stay again
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Donna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great hotel with a friendly staff. The on-site restaurant is a great spot fir a cocktail after a day of exploring.
Stayed 2 nights in Mar 2026
Verified

8/10 Good

Heather

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room | quick check-in | coffee shop, restaurant and bar inside | small art museum inside | beautiful floral stairwell
Stayed 1 night in Apr 2026
Verified

8/10 Good

Charles

Liked: Cleanliness, amenities
A very unique hotel with art center, excellent à la cart breakfast (included) and ample parking options.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!
Stayed 2 nights in Mar 2026