21C Museum Hotel St Louis

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Luxury
4.5 star property
9.0

Wonderful

Luxury hotel near Enterprise Center

Close to City Museum and St. Louis Union Station, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business centre, guests can connect to free in-room WiFi.

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning
The current price is ฿4,828
฿5,813 total
includes taxes & fees
15 Nov - 16 Nov

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(137 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

A hotel room with two beds, a large window, a modern ceiling light, and a view of a staircase.

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(43 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

A hotel room with a bunk bed, a round table with a chair, a potted plant, and a colorful abstract painting on the wall.

Room (Bunk Bed)

8.6 out of 10
Excellent
(10 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

A hotel room with two beds, a large padded headboard, a flat-screen TV, a window with a city view, and a small side table with a plant.

Loft, 2 Queen Beds

7.6 out of 10
Good
(5 reviews)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

A hotel room with a large bed, a desk, a chair, a nightstand, and a mirror.

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

A hotel room with a large bed, a wooden headboard, a nightstand with a lamp, a green armchair, and a large painting on the wall.

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Room

Luxury Suite, 1 King Bed

9.4 out of 10
Exceptional
(3 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

A hotel room with two beds, a sofa, a TV, and a large abstract painting.

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

A hotel room with a large bed, a desk with a chair, a small table, and a lamp.

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About the area

Located in St. Louis, 21C Museum Hotel St Louis is in the city centre. St. Louis Union Station and Gateway Arch are notable landmarks, and some of the area's popular attractions include St. Louis Zoo and Missouri Botanical Garden. Looking to enjoy an event or a game? See what's going on at Enterprise Center or Dome at America’s Center. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • The National Blues Museum in Saint Louis, Missouri.
    Washington Avenue Historic District
    2 min walk - 0.2 km
  • A tightrope walker balancing on a wire between buildings.
    City Museum
    5 min walk - 0.4 km
  • A historic building with a clock tower and red-roofed structures.
    St. Louis Union Station
    8 min walk - 0.7 km
  • A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.
    Enterprise Center
    8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station
    11 min walk - 1.0 km

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • Lambert-St. Louis International Airport (STL)
    24 min drive

Restaurants

  • Rosalita's Cantina
    6 min walk
  • Hair of the Dog
    7 min walk
  • Good Press
    1 min walk
  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Medina Grill
    5 min walk

About this property

21C Museum Hotel St Louis

  • Luxury hotel near Enterprise Center
  • Close to City Museum and St. Louis Union Station, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business centre, guests can connect to free in-room WiFi.
  • You'll also enjoy the following perks during your stay:
    • An indoor pool
    • Cooked-to-order breakfast (surcharge), valet parking (surcharge) and a vending machine
    • A 24-hour front desk, concierge services and smoke-free property
    • Luggage storage, meeting rooms and ATM/banking services
    • Guest reviews say great things about the dining options, pool and helpful staff
  • Room features
  • All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks such as free WiFi and desk chairs. Guest reviews highly rate the cleanliness rooms at the property.
  • More amenities include:
    • Free toiletries and hairdryers
    • Flat-screen TVs with premium channels
    • Wardrobes/cupboards, heating and daily housekeeping

Awards and affiliations

  • Eco-certified property
  • This property is certified by this third-party sustainability certification scheme: Green Key Global. For more information on what this certification requires and verifies, please visit their website.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 55 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Non-plastic coffee stirrers available
  • Non-plastic drinking straws available
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available

Payment types at the property

  • American Express
  • Mastercard
  • Visa

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 55 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 21 Oct 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 15 Nov 2026 start from ฿4,828, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at 21C Museum Hotel St Louis ?

Valet parking is available for USD 55 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Checkout is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Washington Avenue Historic District, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2

Cleanliness

9.0

Amenities

9.0

Staff & service

9.2

Property conditions & facilities
Rating 10 - Excellent. 1498 out of 2129 reviews
Rating 8 - Good. 329 out of 2129 reviews
Rating 6 - Okay. 157 out of 2129 reviews
Rating 4 - Poor. 67 out of 2129 reviews
Rating 2 - Terrible. 78 out of 2129 reviews

Reviews

Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Unique and beautiful hotel. Staff is efficient and friendly.
Stayed 1 night in Oct 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Love this hotel. Great stay for our entire family.
Stayed 3 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was wonderful
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean, staff were helpful, Art was really neat. Also one of the nicest hotel gyms I’ve ever experienced. Very large pool and hot plus other spa accommodations. Overall really enjoyed our stay here and would definitely go back.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent hotel , friendly , loved all public area including the pool
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Wonderful, fun place to stay! Staff was great. Clean and inviting with amazing art. And want to return!
Stayed 2 nights in Sep 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, property conditions & facilities
Wonderful vibrant bar and restaurant scene. Location is walkable, but we had to use the valet parking which was an additional cost of $55 per day since the hotel did not have parking.
Stayed 2 nights in Oct 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Fun hotel. Nice restaurant. I did not use the pool. Good location. Front desk pleasant and helpful.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room clean. Staff friendly.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beds were very comfy
Stayed 3 nights in Jul 2026
Verified review

8/10 Good

Liked: Staff & service, amenities
The hot tub and pool were great. The room was okay. The service at the restaurant and bar was great as well.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful property. Everyone was so kind and so helpful. The art museum was very impressive for a free hotel museum! We unfortunately didn’t have time for the pool and spa areas! Also a great location.
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel full of art. Bathrooms were nicely clean and renovated. Staff were very nice.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The property was clean, comfortable, and well maintained. The staff was friendly and helpful throughout my stay. I enjoyed the location and overall atmosphere. It was a pleasant experience, and I would consider staying here again.
Stayed 1 night in Aug 2026
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Pool and hot tub where great
Stayed 2 nights in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Friendly staff Helpful Courteous Great location for downtown activities
Stayed 1 night in Jul 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Cool hotel with a great restaurant and bar! Not much around there to speak of though.
Stayed 3 nights in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A bit off the beating path, but well worth the walk or ride there. Unfortunately I was only there for a day, so missed out on many of the amenities. But will definitely book here again and take advantage of all they have to offer. P.S. The room are well kept, roomy, and comfortable.
Stayed 1 night in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Such an amazing place. We were on a road trip and needed a place where everything was there. This was it! We LOVED the pool and spa. And the art exhibit was beautiful!
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!
Stayed 1 night in Feb 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
21C Museum St Louis is my favorite hotel. It is so vibrant. I love to swim and that YMCA pool built in the 1920s is gorgeous with hot tub and sauna. You get great coffee in the room, not the typical swill. The museum exhibits are thoughtfully curated and edgy. And they are featured in the old YMCA basketball court! Our room was lovely—the whole place is. This hotel is a destination for locals, it’s the place to be. Idol Wolf is the first outstanding restaurant experience I’ve had in a hotel.
Stayed 2 nights in Sep 2026
Verified review

6/10 Okay

Liked: Cleanliness, staff & service
Disliked: Property conditions & facilities
Room was clean amenities were okay but the tub shower head and tap were not functioning properly. I was not able to turn it to tap fromshower head.
Stayed 2 nights in Sep 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, Nice, comfortable.
Stayed 1 night in Aug 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great interesting hotel. The steam room and sauna and gym are an absolute bonus!
Stayed 1 night in Jul 2026
Verified review

6/10 Okay

Liked: Amenities
Disliked: Cleanliness, property conditions & facilities
The property it itself is beautiful and the staff was incredibly helpful from the Valet to housekeeping and front desk but it’s clear they have some operational issues that are impacting the timelines of housekeeping and the overall cleanliness of the guest room end public areas. Good property with a ton of potential just needs better management.
Stayed 4 nights in Sep 2026