Our top choices for Southwestern Virginia hotels

Sleep Inn Wytheville I-77 and I-81

Wytheville

George

฿3,026 total

includes taxes & fees

23 Jun - 24 Jun

Suite, 1 King Bed, Accessible, Non Smoking | Desk, iron/ironing board, rollaway beds, free WiFi

Comfort Inn & Suites Hillsville I-77

Hillsville

Scott

฿3,920 total

includes taxes & fees

21 Jun - 22 Jun

La Quinta Inn & Suites by Wyndham Roanoke Salem

Salem

Kelly

฿3,547 total

includes taxes & fees

16 Jun - 17 Jun

The Bolling Wilson Hotel

Wytheville

john

฿6,038 total

includes taxes & fees

1 Jun - 2 Jun

Studio Suite, 1 King Bed, Non Smoking, Hot Tub | Individually decorated, individually furnished, desk, blackout curtains

Super 8 by Wyndham Fort Chiswell/Wytheville Area

Max Meadows

Autumn

฿2,097 total

includes taxes & fees

31 May - 1 Jun

Country Inn & Suites by Radisson, Roanoke, VA

Alpine Hills

Mark

฿4,186 total

includes taxes & fees

7 Jun - 8 Jun

Holiday Inn Express and Suites Wytheville by IHG

Wytheville

Kyle

฿5,106 total

includes taxes & fees

28 Jun - 29 Jun

Travelodge by Wyndham Wytheville

Wytheville

tracy

฿2,293 total

includes taxes & fees

31 May - 1 Jun

Hyatt Place Blacksburg / University

McBryde

Prajakta

฿3,687 total

includes taxes & fees

29 Jun - 30 Jun

General Francis Marion Hotel

Marion

Liviu

฿3,828 total

includes taxes & fees

1 Jun - 2 Jun

Americas Best Value Inn & Suites Independence VA

Independence

Deborah

฿2,772 total

includes taxes & fees

2 Jun - 3 Jun

Comfort Suites Wytheville near Conference Center

Wytheville

Bernice

฿3,504 total

includes taxes & fees

28 Jun - 29 Jun

Desk, free cots/infant beds, free WiFi, bed sheets

Red Roof Inn Hillsville

Hillsville

Richard

฿2,833 total

includes taxes & fees

14 Jun - 15 Jun

Fairfield Inn & Suites by Marriott Roanoke Salem

Salem

Oliver

฿4,206 total

includes taxes & fees

21 Jun - 22 Jun

Tru by Hilton Wytheville

Wytheville

Alan

฿3,964 total

includes taxes & fees

22 Jun - 23 Jun

Country Inn & Suites by Radisson, Wytheville, VA

Wytheville

David

฿3,777 total

includes taxes & fees

21 Jun - 22 Jun

Hampton Inn by Hilton Abingdon

Abingdon

Paul

฿4,759 total

includes taxes & fees

28 Jun - 29 Jun

Days Inn by Wyndham Wytheville

Wytheville

Renee

฿2,294 total

includes taxes & fees

29 Jun - 30 Jun

Garner Hotel Wytheville East by IHG

Wytheville

Naveen

฿3,448 total

includes taxes & fees

4 Jun - 5 Jun

Motel 6 Bristol, VA

Bristol

Matthew

฿2,737 total

includes taxes & fees

2 Jun - 3 Jun

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Holiday Rentals in Southwestern Virginia

Aparthotel

The West End Flats

West End

"It's a beautiful space. The host was super helpful. Check in and check out was easy. The location is great. We visited several local restaurants and the transportation museum because of the informational packet within the unit. We would definitely stay again and recommend this place to our friends and family."

Apartment

Apt w/ Lake Views - Day Trip to Virginia Tech!

Radford

"This was a great stay! Quiet, peaceful, and beautiful! Host had great hospitality, super kind, and very accommodating! We will definitely stay here again when in the area next! Highly recommended! :)"

Cabin

New River 3BR - Fishing, Kayaking, Hot tub, VT Game Weekends

Belspring

Cottage

Cozy Cottage Near Dtwn Dining, Walk to Casino

Bristol

"Quiet neighborhood, close to Hard Rock casino. "

Cottage

Cozy Damascus Cottage w/ Porch & Trail Access!

Damascus

Cottage

Walk to River & Trails: Cozy Damascus Cottage!

Damascus

"Perfect little cottage, newly renovated, very clean, literally 15 feet from the AT. Very much enjoyed my stay!"

Apartment

Bristol Escape w/ Patio, 2 Mi to Downtown!

Bristol

"It was so cozy nice weekend getaway "

Cottage

Cozy Fries Escape w/ Mountain & River Views!

Fries

"The family and I loved this place. Clean, comfortable, has everything well organized, great location, great view of New River. "

Cottage

Home w/ Bunkroom: 2 Mi to Hatfield & Mccoy Trail

Bluefield

"Very nice place to stay, like brand new inside."

Apartment

Comfy Damascus Apartment - Walkable Location

Damascus

Cottage

'trout House' in Dtwn Damascus: Near Creeper Trail

Damascus

"Very clean and amazing stay. Felt at home!"

Cottage

Quiet Max Meadows Cabin, 12 Acres of Property

Max Meadows

"Great place; nothing anywhere near it"

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Stay near popular Southwestern Virginia attractions

Virginia Tech University

4.8/5 (1,791 reviews)

Explore the campus of Virginia Tech University during your trip to Blacksburg. You can attend a sporting event while in the area.

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Learn more about Southwestern Virginia

Experience the family-friendly area of Southwestern Virginia—mountain views, restaurants and sights from Wytheville Meeting Center to Wohlfahrt Haus Dinner Theatre.

See all hotels in Southwestern Virginia

Top Southwestern Virginia Hotel Reviews

Sleep Inn Wytheville I-77 and I-81

10/10 Excellent

"Quiet, snug and an excellent bed. Great night’s sleep."

The Inn at Virginia Tech and Skelton Conference Center

10/10 Excellent

"We had such a wonderful stay at the Inn. Our room was immaculately cleaned by Candy and she left us a nice note. We were celebrating our anniversary so the staff upgraded us and left us a personal note wishing us a happy anniversary. Ivola at the front desk was so kind and polite and made us feel at home. The Inn is beautiful on the inside and outside. The atmosphere was quiet and peaceful. We will definitely stay here again in the future."

Ramada by Wyndham Wytheville

6/10 Okay

"As of May 2026, this place is undergoing some much needed TLC. Rolls of carpet and padding were in the exterior corridors. All guests are being booked in one general area. Elgenius was extremely concerned when I reported a non working refrigerator. We were relieved when we realized it was not plugged in. There were unopened, warm, boxed pizzas in the refrigerator. This shows the cleaning staff did not notice there were items in the refrigerator and that it was not cooling. The room was clean but not overly so. If you are staying one night and want a reasonable place to stay, go ahead. If you are staying longer or expect clean and crisp, stay away. When the renovation project is complete, perhaps things will be better. Oh, the walkway by the exterior rooms are badly in need of a power washing."

Tru By Hilton Christiansburg

10/10 Excellent

"Everything was great. Just a quick stay while traveling. The only thing I’d like to see is more than two towels in bathroom. Women use one for their hair too so an extra one would be nice. Beds were comfy, breakfast was what you’d expect, quiet, clean and overall a great stay."

The Promissory Hotel

10/10 Excellent

"It is a lovely hotel. The room was new and well-appointed with some of the old bank building charm. It's upscale while being quaint and comfortable. We were on the 4th floor. The room had amazing upper windows. Very cool! The staff was lovely. Very accommodating and friendly. The location is ideal, right in the middle of town. We were very happy to stumble upon the Promissory Hotel!"