Southeast Missouri Travel Guide

Tourist Guide

Southeast Missouri
Southeast Missouri
Southeast Missouri
Photo by Jessica Richter
Photo by Jessica Richter
Photo by Jessica Richter
Photo by Jessica Richter
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is ฿2,926 per night from 26 Oct to 27 Oct
฿2,926
฿3,301 total
26 Oct - 27 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,015 reviews)
"Great staff"

Reviewed on 12 Oct 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is ฿1,795 per night from 8 Nov to 9 Nov
฿1,795
฿2,044 total
8 Nov - 9 Nov
includes taxes & fees
Stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,012 reviews)
"Overall it’s a good place to stay for the night. Left to early to have breakfast. Had requested a rollaway, apparently none were available, didn’t find that out till we checked in. A heads up would have been nice. We managed. Would stay again, not enough reason not to."

Reviewed on 12 Oct 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
The price is ฿3,717 per night from 19 Oct to 20 Oct
฿3,717
฿4,193 total
19 Oct - 20 Oct
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free Wi-Fi, free parking and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and ...
9.2/10 Wonderful! (433 reviews)
"Newer hotel so clean. Walk-in shower with no door but works. Control is on opposite side of shower head so alittle awkward. Starbucks was nice. Front desk very accommodating. Close to old downtown but too far to walk. Railroad tracks on east side but didn’t reallly hear."

Reviewed on 7 Oct 2025

The Riverview
See all 594 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St. Francois

Postcard Cabins St. Francois

2 out of 5
7555 State Hwy Y, French Village, MO
Stay at this cabin in French Village. Enjoy free parking, patios and climate control.
9.8/10 Exceptional! (39 reviews)
"Everything was very clean and many things provided to make our stay more fun and comfortable. Staff were very nice and informative. Definitely looking forward to another stay."

Reviewed on 3 Oct 2025

Postcard Cabins St. Francois
Sam A Baker State Park

Sam A Baker State Park

2 out of 5
5732 State Hwy Missouri 143, Patterson, MO
Stay at this cabin in Patterson. Enjoy free parking, a picnic area and furnished patios. Popular attraction Sam A. Baker State Park is located nearby.
9/10 Wonderful! (4 reviews)
"We stayed two nights and we loved it. The property grounds and cabins are well maintained we will be back"

Reviewed on 5 Oct 2025

Sam A Baker State Park
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172, Williamsville, MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
10/10 Exceptional! (1 review)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."

Reviewed on 28 Sept 2025

Lake Wappapello
See all properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Elephant Rocks State Park

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Elephant Rocks State Park
Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls
Lake Wappapello

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Lake Wappapello

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Southeast Missouri State University

Century Casino Caruthersville

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Century Casino Caruthersville

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

Current River State Park

Things to do

St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

฿1,115
per adult
St. Louis: Museum of Illusions Entry Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

฿765
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
Best of St. Louis Small Group Tour w/ Arch & River Cruise

Best of St. Louis Small Group Tour w/ Arch & River Cruise

฿5,385
per adult
84% of travellers recommend
Best of St. Louis Small Group Tour w/ Arch & River Cruise
Step into the shadows and discover the haunting tales of our city's past.

St. Louis Ghosts: Gateway Ghouls and Hauntings

฿956
per adult
100% of travellers recommend
St. Louis Ghosts: Gateway Ghouls and Hauntings
St. Louis Arch Walking Tour and Entrance Ticket

St. Louis Arch Walking Tour and Entrance Ticket

฿1,513
per adult
74% of travellers recommend
St. Louis Arch Walking Tour and Entrance Ticket
St. Louis: Guided Small Group City Tour with River Cruise

St. Louis Premium Driving Tour with Boat Ride & Arch

฿5,544
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
See all activities in Southeast Missouri

Cities near Southeast Missouri

Photo by Karissa Krull

Farmington