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Find hotels in Southeast Missouri, MO from ฿1,952

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Our top choices for Southeast Missouri hotels

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1007)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ฿2,492
฿2,840 total
includes taxes & fees
9 Jan - 10 Jan
Best Western Plus Sikeston

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (467)
Surrounded by tranquil environments for rest and relaxation, this Caruthersville hotel offers gaming excitement at the on-site casino. Clean rooms and helpful staff earn praise from guests, while Century Casino and the public library wait just minutes away.

"Clean room, very nice staff"
United States
Mack
The price is ฿2,695
฿3,065 total
includes taxes & fees
6 Jan - 7 Jan
The Farmstead Hotel

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1005)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"Great place. Friendly staff clean"
United States
Jeff
The price is ฿2,837
฿3,261 total
includes taxes & fees
11 Jan - 12 Jan
Drury Inn & Suites Sikeston, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1007)
Enjoy a welcoming stay at this motel with free WiFi and parking near North Main Street Historic District. Staff receives praise for helpfulness, while convenient access to Margaret Harwell Art Museum enriches your Poplar Bluff experience.

"It was a nice stay."
United States
Rebecca
The price is ฿2,396
฿2,629 total
includes taxes & fees
6 Jan - 7 Jan
Motel 6 Poplar Bluff, MO

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (727)
Enjoy tranquil accommodation at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Clean room and easy access to room"
United States
Anne
The price is ฿1,749
฿1,994 total
includes taxes & fees
6 Jan - 7 Jan
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (682)
"Conveniently located, clean, friendly staff."
United States
Philip
The price is ฿2,653
฿2,871 total
includes taxes & fees
11 Jan - 12 Jan
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Town House Inn

Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (428)
This well-located motel offers complimentary WiFi and self parking, with easy access to Shawnee National Forest and Mississippi River. Near attractions like Litz Park and Lazy L Safari Park, guests praise the helpful 24-hour staff.

"The staff member Tim was very friendly and nice. "
United States
Julie
The price is ฿2,213
฿2,395 total
includes taxes & fees
6 Jan - 7 Jan
Town House Inn

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
This centrally located hotel offers convenient access to restaurants and shopping. Take advantage of the indoor pool and fitness centre after exploring nearby Cape Splash Family Aquatic Centre. Free breakfast, WiFi, and parking enhance your stay with attentive staff ready to assist.

"Breakfast was very good and staff was extremely friendly and rooms were very clean "
United States
Rex
The price is ฿2,995
฿3,379 total
includes taxes & fees
25 Jan - 26 Jan
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (733)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.

"Friendly sta"
United States
Melissa
New Orleans Inn Portageville

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1011)
Explore Shawnee National Forest from this Cape Girardeau hotel offering complimentary breakfast, WiFi, and parking. Enjoy the indoor pool and hot tub after a day out, or dine at The Southerner restaurant. Each room includes handy refrigerators and microwaves.

"This is one of the best properties. We are in the area often, it's the best."
United States
James
The price is ฿2,837
฿3,200 total
includes taxes & fees
14 Jan - 15 Jan
Drury Plaza Hotel Cape Girardeau Conference Center

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (915)
Peaceful hotel close to Sunset Park offers free breakfast, WiFi, and parking. Guests love the minimal noise levels and helpful staff. The fitness centre provides workout options while being just a 10-minute drive from Mississippi River attractions.

"Clean room. Easy check in"
United States
Henrick
The price is ฿2,385
฿2,787 total
includes taxes & fees
7 Jan - 8 Jan
Comfort Inn Festus - St Louis South

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (335)
Set in scenic Mountain View, this welcoming hotel offers free breakfast, WiFi, and parking. Enjoy 24-hour fitness facilities or explore nearby hiking trails. Guests consistently praise the helpful staff and immaculate rooms.

"Staff was very friendly."
United States
Joyce
The price is ฿2,837
฿3,075 total
includes taxes & fees
11 Jan - 12 Jan
Honeysuckle Inn - Mountain View

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1005)
This quiet retreat offers an indoor pool for morning swims and a relaxing hot tub to end your day. Clean rooms provide a peaceful atmosphere near Litz Park and Lazy L Safari Park, with free breakfast, WiFi, and parking to enhance your stay.

"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ฿2,616
฿2,766 total
includes taxes & fees
6 Jan - 7 Jan
Drury Inn & Suites Jackson MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (456)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness centre. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.

"Very clean and super friendly staff!"
United States
Katherine
The price is ฿3,178
฿3,599 total
includes taxes & fees
11 Jan - 12 Jan
Hampton Inn Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (616)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.

"Staff was great! Room was nice. "
United States
Lana
The price is ฿1,958
฿2,172 total
includes taxes & fees
6 Jan - 7 Jan
Super 8 by Wyndham Charleston/Sikeston East MO

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
This welcoming Ironton hotel sits near the train station and Shepherd Mountain Bike Park. Enjoy a complimentary breakfast before heading out, then return for drinks at the bar. Clean rooms, free WiFi, and attentive staff create a pleasant, convenient base for your adventures.

"Everything was wonderful- the family that owns this is very kind, and it’s in a beautiful location!"
United States
Nathan
Shepherd Mountain Inn

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (864)
"The size of the room. The staff were great. The room was very clean. Will definitely stay there again."
United States
Brenda
The price is ฿3,279
฿3,704 total
includes taxes & fees
9 Jan - 10 Jan
Fairfield Inn & Suites by Marriott Poplar Bluff

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (445)
Discover comfort at this Sikeston hotel with an indoor pool and fitness centre. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.

"Stay was excellent "
United States
Kourtney
The price is ฿2,932
฿3,319 total
includes taxes & fees
11 Jan - 12 Jan
Holiday Inn Express & Suites Sikeston Southwest by IHG

Quality Inn Farmington

Quality Inn Farmington
2.5 star property
Farmington
7.6 out of 10, Good, (863)
In Farmington, this welcoming hotel offers an indoor pool and free breakfast, parking, and WiFi. Hiking trails beckon nearby, while clean rooms provide a comfortable base for exploring Bicentennial Park. Guests consistently praise the helpful staff.

"The staff was friendly. We had a few issues with our stay but overall was good. Love there breakfast variety "
United States
edith
The price is ฿1,661
฿1,981 total
includes taxes & fees
1 Feb - 2 Feb
Quality Inn Farmington

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (901)
Enjoy a peaceful retreat at this Festus hotel offering complimentary breakfast, WiFi, and parking. The fitness centre provides workout options while the helpful staff ensures a pleasant stay. Located conveniently near Jorkerst Memorial Park and Sunset Park.

"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is ฿2,921
฿3,340 total
includes taxes & fees
11 Jan - 12 Jan
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southeast Missouri

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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

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