Search Hotels in Serra Mesa, San Diego

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Top Trending Hotels Near Serra Mesa, San Diego

Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3097)
"Our stay was great! Would stay here again"
United States
Carla
The price is ฿8,429
฿11,256 total
includes taxes & fees
25 Nov - 26 Nov
Hard Rock Hotel San Diego
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6059)
"I enjoyed my stay."
United States
Kevin
The price is ฿4,380
฿6,018 total
includes taxes & fees
25 Nov - 26 Nov
Wyndham San Diego Bayside
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1226)
"Very friendly staff!"
United States
Glenn
The price is ฿4,104
฿4,758 total
includes taxes & fees
26 Nov - 27 Nov
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 10.1 km from Serra Mesa
8.6 out of 10, Excellent, (2045)
"staff was very friendly and hotel was clean"
United States
Stephany
The price is ฿3,403
฿3,945 total
includes taxes & fees
25 Nov - 26 Nov
Palihotel San Diego Gaslamp Quarter
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3445)
"Clean, staff friendly, great place for a stay"
United States
Derrick
The price is ฿3,471
฿3,825 total
includes taxes & fees
30 Nov - 1 Dec
Best Western Plus Marina Gateway Hotel
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (2664)
"Beautiful and historic, very comfortable. Would definitely stay there again. "
United States
Amy
The Horton Grand, Downtown/Gaslamp Quarter
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
9.0 out of 10, Wonderful, (1008)
"Great room, clean, spacious and quiet. "
United States
Maria
The price is ฿3,208
฿3,649 total
includes taxes & fees
25 Nov - 26 Nov
Gaslamp Plaza Suites
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1436)
"Great stay, clean room. Staff was very friendly as well. Would stay again. "
United States
Alexis
The price is ฿4,060
฿4,708 total
includes taxes & fees
8 Dec - 9 Dec
The Bristol Hotel San Diego
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1001)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ฿3,380
฿4,855 total
includes taxes & fees
25 Nov - 26 Nov
Staypineapple, Hotel Z, Gaslamp San Diego
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very good, (1635)
"Excellent stay all-around!"
United States
Nalani
The Sofia Hotel
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1926)
"Great hotel"
United States
Farzana
The price is ฿5,152
฿7,678 total
includes taxes & fees
30 Nov - 1 Dec
Marriott Marquis San Diego Marina
Presidential Suite, 2 Bedrooms | Living room | 36-inch LCD TV with digital channels, TV, pay films
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4.0 star property
9.9 km from Serra Mesa
9.0 out of 10, Wonderful, (854)
"Lovely hotel. Really enjoyed the complimentary bottle of wine as well as how convenient it was to walk to restaurants & bars . "
United States
Gisselle
The price is ฿3,834
฿5,760 total
includes taxes & fees
16 Dec - 17 Dec
Alma San Diego Downtown, a Tribute Portfolio Hotel
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
5.7 km from Serra Mesa
9.2 out of 10, Wonderful, (2959)
"Great stay"
United States
Songkwon
The price is ฿5,220
฿6,001 total
includes taxes & fees
7 Dec - 8 Dec
Legacy Resort Hotel & Spa
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3136)
"Great staff and beautiful location. "
United States
elaine
The price is ฿3,704
฿4,257 total
includes taxes & fees
25 Nov - 26 Nov
Bay Club Hotel & Marina
Exterior
La Pensione Hotel

La Pensione Hotel

3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1909)
"Friendly staff, very nice room, great location!"
United States
Lisa
La Pensione Hotel
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (669)
"Great staff, great location, great value. "
United States
Juan
The price is ฿2,903
฿3,366 total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Diego Mission Bay

La Quinta Inn & Suites by Wyndham San Diego Mission Bay

3.0 star property
North Pacific Beach, 7.4 km from Serra Mesa
8.0 out of 10, Very good, (1409)
"Great place We will stay here again. "
United States
Derek
The price is ฿3,002
฿3,452 total
includes taxes & fees
25 Nov - 26 Nov
La Quinta Inn & Suites by Wyndham San Diego Mission Bay
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1034)
"Spacious rooms , great staff "
United States
Jessica
The price is ฿3,834
฿5,384 total
includes taxes & fees
20 Dec - 21 Dec
The Westin San Diego Bayview
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1133)
"Great Hotel - good position and very helpful staff. "
United Kingdom
James
The price is ฿5,206
฿7,351 total
includes taxes & fees
14 Dec - 15 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

3.5 star property
Mission Bay, 10.1 km from Serra Mesa
8.8 out of 10, Excellent, (3879)
"Overall, nice place to stay!"
United States
Jazmine
The price is ฿5,152
฿6,570 total
includes taxes & fees
25 Nov - 26 Nov
The Dana on Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Would recommend "
Zulma 4-night trip
Posted 3 days ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

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Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.