Find hotels in Santee, SC from ฿2,052

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Check prices for these dates

This weekend
29 May - 31 May
Next weekend
5 Jun - 7 Jun

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Our top choices for Santee hotels

Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,460 reviews)
"Great overnight stop"
United States
Gary
The price is ฿2,447
฿2,716 total
includes taxes & fees
31 May - 1 Jun
Baymont by Wyndham Santee
Free daily full breakfast

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (535 reviews)
"Rooms are clean and staff was super nice and accommodating "
United States
Will
The price is ฿1,775
฿2,151 total
includes taxes & fees
18 Jun - 19 Jun
Quality Inn & Suites Santee I-95
Property amenity

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,000 reviews)
"Convenient location & clean with very nice staff"
United States
Michael
The price is ฿4,376
฿4,858 total
includes taxes & fees
8 Jun - 9 Jun
Fairfield Inn & Suites by Marriott Santee
Free breakfast

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,001 reviews)
"Great stay!"
United States
Preston
The price is ฿4,180
฿4,640 total
includes taxes & fees
14 Jun - 15 Jun
Hampton Inn Santee-I-95
In-room safe, iron/ironing board, free WiFi, bed sheets

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (731 reviews)
"Staff was very friendly. "
United States
Sriram
The price is ฿2,056
฿2,282 total
includes taxes & fees
1 Jun - 2 Jun
Travelodge by Wyndham Santee
Free daily buffet breakfast

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (836 reviews)
"This property is convenient to I-95 and is clean with a welcoming staff, lots of amenities, and great breakfast. Will be back on my next travels."
United States
June
The price is ฿3,492
฿3,876 total
includes taxes & fees
14 Jun - 15 Jun
Tru By Hilton Santee
Frette Italian sheets, premium bedding, pillow-top beds

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,002 reviews)
"This property is right off the interstate with no traffic. The staff was very friendly and the hotel was clean. Breakfast and coffee were delicious. Highly recommend "
United States
Kimberley
The price is ฿3,301
฿3,664 total
includes taxes & fees
28 Jun - 29 Jun
Comfort Inn & Suites Santee
Exterior

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,001 reviews)
"Great breakfast bar - beautiful location in golf course and easy parking. "
United States
Nicole
The price is ฿3,800
฿4,218 total
includes taxes & fees
21 Jun - 22 Jun
Best Western Plus Santee Inn
Lobby

Super 8 by Wyndham Santee

Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (465 reviews)
"Ok hotel when money is tight. Only stayed one night but the room was clean and the beds were pretty comfy."
United States
Christalyn
The price is ฿2,080
฿2,309 total
includes taxes & fees
3 Jun - 4 Jun
Super 8 by Wyndham Santee
Children’s activities

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"Room was super clean and nice. Convenient location off of 95 and near Santee state park. Only minor complaint is the pool wasn't heated as stated. "
United States
Stefanie
The price is ฿3,100
฿3,441 total
includes taxes & fees
28 Jun - 29 Jun
Holiday Inn Santee by IHG
Lobby

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (562 reviews)
"Clean room and good staff"
United States
Herbert
The price is ฿2,328
฿2,584 total
includes taxes & fees
22 Jun - 23 Jun
Ramada by Wyndham Santee I-95
Exterior

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (655 reviews)
"The check in lady was uncooperative & unhelpful. Only 1 towel for each person. Would not recommend. "
United States
Dave
The price is ฿2,056
฿2,282 total
includes taxes & fees
1 Jun - 2 Jun
Red Roof Inn Santee
Desk, iron/ironing board, free WiFi, bed sheets

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (314 reviews)
"Very clean room, fast staff, a lot of food spots nearby! "
United States
Santiana
The price is ฿2,481
฿2,754 total
includes taxes & fees
11 Jun - 12 Jun
Econo Lodge Santee
Dining

Southern Lodge 601

Southern Lodge 601
Orangeburg
7.6 out of 10, Good, (9 reviews)
"The front desk and housekeeping staff were friendly and accommodating. The room was clean and comfortable but had a little "stale" odor but I became accustomed to it quickly. I felt safe in my room, and the neighbors were very quiet. Will stay here again, great bargain and convenient to I-26!"
United States
Stephanie
The price is ฿2,203
฿2,446 total
includes taxes & fees
2 Jun - 3 Jun
Southern Lodge 601
Suite, 1 King Bed, Accessible, Smoking | Desk, blackout curtains, iron/ironing board, free WiFi

Quality Inn & Suites Orangeburg

Quality Inn & Suites Orangeburg
2.5 star property
Orangeburg
6.2 out of 10, (667 reviews)
"Room was very spacious and clean. Staff was very friendly and helpful. Breakfast wasn't bad (it did include hot eggs and biscuits and gravy), but was lacking compared to other similarly priced hotels we've stayed at on this road trip. The area was easy to get to, but did seem a little sketchy and was quite loud in the early morning. "
Canada
Michelle
The price is ฿2,144
฿2,380 total
includes taxes & fees
10 Jun - 11 Jun
Quality Inn & Suites Orangeburg
Front of property

Peach Tree Inn

Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (212 reviews)
"Was very clean and confortable "
United States
David
The price is ฿1,942
฿2,098 total
includes taxes & fees
1 Jun - 2 Jun
Peach Tree Inn
Desk, iron/ironing board, free WiFi, bed sheets

Baymont by Wyndham Orangeburg North

Baymont by Wyndham Orangeburg North
2.5 star property
Orangeburg
6.0 out of 10, (1,001 reviews)
"Clean rooms enjoyed my stay."
United States
Rontisha
The price is ฿1,803
฿2,001 total
includes taxes & fees
10 Jun - 11 Jun
Baymont by Wyndham Orangeburg North
Breakfast area

Travelodge by Wyndham Orangeburg

Travelodge by Wyndham Orangeburg
2.0 star property
Orangeburg
8.2 out of 10, Very good, (1,002 reviews)
"Clean rooms, great staff, easy parking"
United States
Leslie
The price is ฿2,578
฿2,862 total
includes taxes & fees
31 May - 1 Jun
Travelodge by Wyndham Orangeburg
Lobby

Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
3.0 star property
Orangeburg
8.4 out of 10, Very good, (778 reviews)
"Great stay!!"
United States
Laylany
The price is ฿3,578
฿3,972 total
includes taxes & fees
8 Jun - 9 Jun
Fairfield Inn by Marriott Orangeburg
Free daily on-the-go breakfast

Super 8 by Wyndham, Orangeburg

Super 8 by Wyndham, Orangeburg
2.0 star property
Orangeburg
7.0 out of 10, Good, (982 reviews)
"Coffee not great okay breakfast Room was comfortable for an overnight stay"
United States
sandra
The price is ฿2,056
฿2,282 total
includes taxes & fees
11 Jun - 12 Jun
Super 8 by Wyndham, Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santee attractions

Santee State Park

4.0/5 (219 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
See properties

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

10/10 Excellent
"Clean room nice respect staf"
Stephanie 1-night trip
Posted 2 hours ago
Comfort Inn & Suites Santee

More cheap stays in Santee

Peach Tree Inn

Peach Tree Inn

111 Conners Dr St. George SC
The price is ฿1,942 per night from 1 Jun to 2 Jun
฿1,942
฿2,098 total
1 Jun - 2 Jun
includes taxes & fees
7.2/10 Good! (212 reviews)

Frequently asked questions

Where is the best place for a stay in Santee?
Based on our traveller data, Baymont by Wyndham Santee is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your visit include Tru By Hilton Santee and Comfort Inn & Suites Santee. See all available top hotels, or vacation rentals in Santee.
If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What's the best place to stay on a budget in Santee?
Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Santee.
What's the best family accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another good option for your stay with the kids. Find more child-friendly accommodations in Santee.
What is the top LGBTQ-friendly accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are two other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santee.
What's the best dog-friendly hotel in Santee?
Baymont by Wyndham Santee is a top hotel for people travelling with their pets, and offers concierge services and free WiFi for its human guests. Two other good options for you and your pet include Tru By Hilton Santee and Best Western Plus Santee Inn. See more pet-friendly hotel accommodations in Santee.
What's the best accommodation for a golf trip to Santee?
Holiday Inn Santee by IHG is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Super 8 by Wyndham Santee and Ramada by Wyndham Santee I-95. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.
What are some accommodation options with pools in Santee?
Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast and free WiFi. Quality Inn & Suites Santee I-95 is an additional hotel with an on-site pool. View all hotels with pools in Santee.
What is staying in Santee like?
Families will find child-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and cafes. In Santee, there are 128 hotels and other accommodation options to choose from. Find out more about Santee.
What are the top places to visit in Santee?
Favourite places to visit include Santee Cooper Country Club, Santee National Golf Club and Santee State Park. A couple of additional sights to add to your itinerary are Lake Marion and Santee Town Hall. Take a look at what more there is to see and do in Expedia's Santee guide.
What's the seasonal weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.

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