Find hotels in Santa Cruz from ฿407

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
1 Sep - 2 Sep
Tomorrow
2 Sep - 3 Sep
This weekend
5 Sep - 7 Sep
Next weekend
12 Sep - 14 Sep

Filter by

Guest rating
Guest rating
Property class

Top 10 Santa Cruz hotels and places to stay

Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG
Bar (on property)

Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG

3.5 star property
9.4 out of 10, Exceptional, (818)
"The hotel is very well situated"
The price is ฿3,508
฿4,210 total
includes taxes & fees
12 Sept - 13 Sept
Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG
Verticca Hotel
Food and drink

Verticca Hotel

3.0 star property
9.4 out of 10, Exceptional, (183)
"Good place to stay "
Verticca Hotel
Lamartine Boutique Hotel Polanco
Superior Studio Suite, 1 King Bed, Balcony | Balcony

Lamartine Boutique Hotel Polanco

5.0 star property
10.0 out of 10, Exceptional, (16)
"Fantastic place. Beautiful, reasonable price and helpful staff."
The price is ฿8,090
฿9,668 total
includes taxes & fees
2 Sept - 3 Sept
Lamartine Boutique Hotel Polanco
Hotel Finca Las Hortensias
Property grounds

Hotel Finca Las Hortensias

3.0 star property
8.2 out of 10, Very good, (179)
"Front desk service was excellent, the food was delicious and the service from Saul was wonderful. "
The price is ฿1,870
฿2,244 total
includes taxes & fees
2 Sept - 3 Sept
Hotel Finca Las Hortensias
Edgar Allan Poe 227 By Ömora
Exclusive Apartment, 1 Bedroom, Patio | Terrace/patio

Edgar Allan Poe 227 By Ömora

3.5 star property
10.0 out of 10, Exceptional, (27)
"Will definitely stay here again. Can’t say one bad thing about this place. "
The price is ฿2,844
฿3,399 total
includes taxes & fees
2 Sept - 3 Sept
Edgar Allan Poe 227 By Ömora
HOTEL CASA KAVIA
Deluxe Double Room | 1 bedroom, in-room safe, bed sheets

HOTEL CASA KAVIA

2.0 star property
9.8 out of 10, Exceptional, (7)
"Small, contemporary hotel at a great location. The front desk staff is a little inexperienced, but they try to please. The hotel manager, Sr. Fernández, goes above and beyond to make you feel welcomed. We would definitely stay here again. "
The price is ฿4,787
฿5,721 total
includes taxes & fees
2 Sept - 3 Sept
HOTEL CASA KAVIA
Fiesta Inn Ecatepec
Indoor pool

Fiesta Inn Ecatepec

3.5 star property
8.8 out of 10, Excellent, (766)
"This property was amazing. It was my second time staying with them but in a different location and it didn’t disappoint. The staff were amazing and the location was great with anything you needed within walking distance. "
The price is ฿3,078
฿3,694 total
includes taxes & fees
5 Sept - 6 Sept
Fiesta Inn Ecatepec
UTOPIC Platón by ULIV
Rooftop terrace

UTOPIC Platón by ULIV

5.0 star property
9.6 out of 10, Exceptional, (68)
"Excellent stay, highly recommend."
The price is ฿5,613
฿6,708 total
includes taxes & fees
7 Sept - 8 Sept
UTOPIC Platón by ULIV
Mala Vecindad Centro Historico
Rooftop pool

Mala Vecindad Centro Historico

3.0 star property
8.8 out of 10, Excellent, (62)
"Friendly, supportive staff members. The place has a very unique decoration, as well as a rooftop with an impressive view of the city. It’s a quiet and relaxing place to rest but also to enjoy with family and friends."
Mala Vecindad Centro Historico
City Express by Marriott Ciudad de México La Villa
Lobby lounge

City Express by Marriott Ciudad de México La Villa

3.0 star property
8.8 out of 10, Excellent, (1014)
"Staff are very nice and friendly. "
The price is ฿2,223
฿2,657 total
includes taxes & fees
6 Sept - 7 Sept
City Express by Marriott Ciudad de México La Villa
UTOPIC Campos Elíseos by ULIV
The Royalty Suite | 1 bedroom, Egyptian cotton sheets, premium bedding, minibar

UTOPIC Campos Elíseos by ULIV

4.0 star property
9.4 out of 10, Exceptional, (555)
"Location of the hotel is amazing, with restaurants and entertainment in all nearby."
UTOPIC Campos Elíseos by ULIV
Downtown Treasure Place
Business centre

Downtown Treasure Place

2.5 star property
8.8 out of 10, Excellent, (654)
"This ok, it's very nice, it's beautiful, "
The price is ฿1,372
฿1,660 total
includes taxes & fees
17 Sept - 18 Sept
Downtown Treasure Place
UTOPIC Polanco by ULIV
Standard Double Suite | City view

UTOPIC Polanco by ULIV

4.5 star property
9.0 out of 10, Wonderful, (619)
"It’s a good place to stay, specially if going for business purposes"
UTOPIC Polanco by ULIV
Capitalia Antara Polanco
Luxury Apartment, Balcony, City View | 1 bedroom, premium bedding, in-room safe, desk

Capitalia Antara Polanco

4.5 star property
9.0 out of 10, Wonderful, (111)
"My stay was very enjoyable, and Karen at the front desk was exceptional!"
Capitalia Antara Polanco
Fiesta Americana México Toreo
Serves breakfast, lunch and dinner

Fiesta Americana México Toreo

4.0 star property
9.6 out of 10, Exceptional, (1009)
"Very good room and amenities "
The price is ฿5,138
฿6,165 total
includes taxes & fees
7 Sept - 8 Sept
Fiesta Americana México Toreo
Hotel Brasilia
Terrace/patio

Hotel Brasilia

3.0 star property
9.0 out of 10, Wonderful, (1010)
"It was a fantastic experience"
The price is ฿1,735
฿2,073 total
includes taxes & fees
15 Sept - 16 Sept
Hotel Brasilia
KALI La Raza Mexico City
Breakfast buffet

KALI La Raza Mexico City

2.5 star property
9.4 out of 10, Exceptional, (165)
"I enjoyed my stay here. Would definitely recommend "
KALI La Raza Mexico City
Autoparador del Valle
Reception

Autoparador del Valle

3.0 star property
7.2 out of 10, Good, (5)
"Affordable nice room"
The price is ฿1,040
฿1,248 total
includes taxes & fees
2 Sept - 3 Sept
Autoparador del Valle
The Wild Oscar
Terrace/patio

The Wild Oscar

4.0 star property
9.6 out of 10, Exceptional, (455)
"This is a great hotel in a lovely location. Polanco is The place to stay in Mexico City. Great staff and welcoming environment. "
The price is ฿6,473
฿7,735 total
includes taxes & fees
2 Sept - 3 Sept
The Wild Oscar
District Polanco by Lumina
Terrace/patio

District Polanco by Lumina

9.4 out of 10, Exceptional, (110)
"The location is top, beautiful neighborhood with great options for dinning and the hotel staff was very sweet and helpful! "
District Polanco by Lumina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

More cheap stays in Santa Cruz

Casa Olea

Casa Olea

C. de Francisco Díaz Covarrubias, 76, Mexico City, CDMX
The price is ฿2,022 per night from 4 Sept to 5 Sept
฿2,022
฿2,416 total
4 Sept - 5 Sept
includes taxes & fees

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place for a stay in Santa Cruz?

Located 18.9 mi (30.5 km) from the heart of Santa Cruz, Hyatt Regency Mexico City is a top choice for your stay, based on our traveller data. Two other choices for your stay in the area are InterContinental Presidente Mexico City by IHG and Casa Olea. See all available top hotels, or vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

What is staying in Santa Cruz like?

Those travelling to Santa Cruz will definitely enjoy the sights to see and things to do. There are 1817 hotels and other accommodation options in the surrounding area. Find out more about Santa Cruz.

What are the top places to visit in Santa Cruz?

Places to visit in the wider area include Hacienda La Concepcion, National Museum of the Viceroyalty and San Marcos Power Center. You'll also find Xochitla Ecological Park and Arcos del Sitio in the area. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.

What's the seasonal weather like in Santa Cruz?

The hottest months are usually April and May, with an average temperature of 18°C, while the coldest months are January and December, with an average of 14°C. The rainiest months in Santa Cruz are August, July, September and June, with each month seeing an average of 186 mm of rainfall.