Santa Clara Packages (Flight + Hotel)

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ฿4,531 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Santa Clara

Find the best Santa Clara areas and neighborhoods for the activities you enjoy most. Learn more about Santa Clara
My favourite store in Casco Viejo by far! It sells #colorful Kuna handmade products and the owner of the gallery is a very kind lady, who even allowed me to visit her place outside working hours. #LikeALocal

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or Museum of History Panama while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Clara

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ฿3,616 per night from 18 Feb to 19 Feb
฿3,616
฿3,977 total
18 Feb - 19 Feb
includes taxes & fees
9/10 Wonderful! (4,837 reviews)
I really loved the service and friendliness of staff. Had 1 bad experience at Ibiza but Arturo made it better. I really loved the resort and will be returning.

Reviewed on 15 Jan 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is ฿3,438 per night from 9 Feb to 10 Feb
฿3,438
฿3,782 total
9 Feb - 10 Feb
includes taxes & fees
8.4/10 Very Good! (2,368 reviews)
Great location. Great hotel. Nice rooms with great amenities. Restaurant food was good but a little pricey but to be expected for next to airport. Definitely stay here sgain.

Reviewed on 18 Jan 2026

Crowne Plaza Panama Airport by IHG
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ฿6,938 per night from 6 Feb to 7 Feb
฿6,938
฿7,632 total
6 Feb - 7 Feb
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
awesome location, great staff

Reviewed on 12 Jan 2026

Waldorf Astoria Panama
See all 1,696 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Clara holiday package cost?
Custom make your Santa Clara holiday package from as little as . Pick from any combination of hotels, flights and rental cars to craft the escape of your dreams. Be sure to add on some tours and experiences!
How do I get a cheap travel package to Santa Clara?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all. Select the combination that best fits you and watch your savings grow. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Clara getaway.
Where should I stay in Santa Clara?
Most travellers who visit Santa Clara include Miraflores Locks and Metropolitan Cathedral of Panama on their must-see lists. Why not select a hotel close to one of these main attractions?
How far in advance should I book my Santa Clara holiday?
Savvy travellers always book early. Air carriers generally advertise flights up to a year prior to departure, and this is a fantastic opportunity to score some of the cheapest prices. Just been told you should take some holiday time next week? No need to worry. Expedia are never short on fantastic deals to whisk you away on the getaway of your dreams, at an affordable price.
What does an Expedia Santa Clara travel package include?
It comes down to what you're looking for. If you're travelling solo, you might decide to combine hotels and flights. Bringing the whole family to Santa Clara? A travel package including flights, hotels and rental cars might suit you better. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking a Santa Clara travel package?
When you book your flights, hotels and car rentals together, you'll pick up awesome discounts. Whether you're organising a beach break in a villa or prefer to stay in an upscale city hotel, Expedia can make it happen for less.
Can I choose my airline with a Santa Clara Expedia holiday package?
Yes, you can. We offer more than 550 airline partners throughout the world, so opt for the carrier that fits your budget and travel needs.
If I'm not able to travel, can I cancel my Santa Clara holiday package?
Because we understand life is full of surprises, the answer is yes. For further details, check out our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for no charge. Your hotel, airline or car rental company may impose a fee if you made your booking a while ago.

Popular places to visit

Panama Canal Railway

Panama Canal Railway

Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this vibrant area.

Panama Canal Railway

Things to do

Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

฿1,010
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

฿2,989
per adult
100% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
MiraLift

Transfer to Panama Canal (Miraflores Locks)

฿441
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.