
Panama Packages (Flight + Hotel)
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ฿4,531 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top destinations in Panama

Panama City
Panama Holiday
While Panama is perhaps best known for its mighty canal, there’s so much more to this Central American country. Visitors will also be wowed by lush rainforests, idyllic beaches, rich indigenous culture and a unique colonial history.
Panama Hotel + Flights
Expedia has 3,581 hotels available here starting at ฿3,778 a night. But if you want to save some serious money, combine your hotel and flights into a Panama Holiday Package. You can also add car rental and activities to your booking to create an unforgettable getaway. With the dollars you save, why not book a tour and visit island paradises or taste famous local flavours like ceviche?
Your Panama Holiday Itinerary
Day 1-2: Start your adventure in the national capital, Panama City, and head straight to Casco Viejo (the Old Quarter). Wander narrow cobblestone streets and discover colourful Spanish colonial houses, beautiful churches and an impressive gastronomic scene. Plan a day trip to the Panama Canal to watch mammoth ships slip through the Miraflores Locks.
Day 3-5: Stay on some of the world’s most spectacular islands in San Blas. Owned and operated by the Kuna people, this untouched paradise on the Caribbean side of Panama is the perfect place to live out your Robinson Crusoe fantasies.
Day 6-8: Head back to Panama City and fly to the mountain town of Boquete. A top destination for outdoor lovers, it offers jungle hikes, whitewater rafting, canopy tours, zip lining and more.
Panama Information
Party with the locals at Carnival, Panama’s largest annual celebration. You’ll find the biggest events in Panama City and Las Tablas.
If you’ll be spending most of your time in the nation’s capital, check out our Panama City Holiday PackagesOpens in a new window.
Want to really experience the carefree vibe of this Latin American gem? Book one of our Panama All Inclusive Resorts and say adios to holiday planning stress.
Top hotels in Panama

Hotel Riu Plaza Panama
What an amazing experience! From the staff to the overall hospitality! Surprised my mom with this trip for her bday and it surpassed my expectations. I will def be returning!
Reviewed on 15 Dec 2025

Crowne Plaza Panama Airport by IHG
The room, restaurant and hotel in general were good but the air conditioning in our room smelt mouldy. Once we turned this off the smell went away.
Reviewed on 17 Dec 2025

Las Americas Golden Tower Panama
It was a very nice stay. The room is nice, organized and clean with a great view of the city. The blankets are a little too warm and we wished for a lighter blankets. Breakfast buffet was very good with many food choices and best custom eggs cooked tailored to our demands. Uber to Casco Viejo was ...
Reviewed on 15 Dec 2025
Frequently asked questions
Popular places to visit
Colon Free Zone
During your trip to Colon, you can do some window-shopping at Colon Free Zone.
What to do in Panama

Panama City: Poin Glass Observation Deck Ticket with VR Tour

