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Check prices for these dates

Tonight
14 Sep - 15 Sep
Tomorrow
15 Sep - 16 Sep
This weekend
18 Sep - 20 Sep
Next weekend
25 Sep - 27 Sep

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Our top choices for Mill Creek hotels

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
ELAINE
฿3,338
฿3,799 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
฿3,305
฿3,728 total
includes taxes & fees
20 Sept - 21 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

3. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
Canada
Raidas
฿2,379
฿2,684 total
includes taxes & fees
20 Sept - 21 Sept
Pear Tree Inn Cape Girardeau West
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

4. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
United States
Teresa
฿2,974
฿3,355 total
includes taxes & fees
20 Sept - 21 Sept
Drury Inn & Suites Cape Girardeau
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A spacious living room with a sofa set, a coffee table, and a dining area.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A lobby with seating areas, a reception desk, and a bar.

5. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
United States
Kristin
฿4,135
฿4,685 total
includes taxes & fees
24 Sept - 25 Sept
Courtyard by Marriott Cape Girardeau Downtown
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

6. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
United States
Rebekah
฿3,496
฿3,944 total
includes taxes & fees
24 Sept - 25 Sept
Hampton Inn Cape Girardeau I 55 East
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

7. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
United States
Stephen
฿1,963
฿2,215 total
includes taxes & fees
21 Sept - 22 Sept
Quality Inn Cape Girardeau North
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

8. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
฿3,778
฿4,262 total
includes taxes & fees
16 Sept - 17 Sept
The Riverview
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

9. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
฿3,343
฿3,771 total
includes taxes & fees
20 Sept - 21 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.

10. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
United States
Joshua
฿2,479
฿2,896 total
includes taxes & fees
24 Sept - 25 Sept
Town House Inn Cape Giradreau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
A hotel patio with a gazebo, outdoor seating, and a view of the road.

11. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
United States
Samuel
฿2,908
฿3,463 total
includes taxes & fees
4 Oct - 5 Oct
Candlewood Suites Cape Girardeau by IHG
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.
A stone building with a patio area, string lights, and outdoor seating.
A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.
A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

12. Makanda Inn

Makanda Inn
Makanda
United States
Michele
Makanda Inn
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Top Mill Creek Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Clean room, nice comfortable beds. It was very quiet and we felt very safe. The only drawback was the toilet was too low."
Judy 1-night trip
Posted 2 hours ago
Pear Tree Inn Cape Girardeau West
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Patti 1-night trip
Posted 1 day ago
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Serapia 1-night trip
Posted 2 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent
"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."
David 1-night trip
Posted 6 days ago
Fairfield Inn & Suites by Marriott Cape Girardeau
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

8/10 Good
"The outside needed cleaning, but the room was very clean and well maintained."
Michael p 1-night trip
Posted 10 days ago
Town House Inn Cape Giradreau
Hotel 7 Inn Anna

Hotel 7 Inn Anna

10/10 Excellent
"Staff were very accommodating and made the stay very pleasant."
Dorothy J 3-night trip
Posted 1 month ago
Hotel 7 Inn Anna
Makanda Inn

Makanda Inn

10/10 Excellent
"I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions."
Tonia 4-night trip
Posted 2 months ago
Makanda Inn

More cheap stays in Mill Creek

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO
฿1,963
฿2,215 total
21 Sept - 22 Sept
includes taxes & fees
7/10 Good! (796 reviews)
Quality Inn Cape Girardeau North
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
฿2,379
฿2,684 total
20 Sept - 21 Sept
includes taxes & fees
9.2/10 Wonderful! (1,007 reviews)
Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO
฿2,908
฿3,463 total
4 Oct - 5 Oct
includes taxes & fees
8/10 Very good! (1,000 reviews)
Candlewood Suites Cape Girardeau by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO
฿3,338
฿3,799 total
20 Sept - 21 Sept
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

207 S Mt Auburn Rd Cape Girardeau MO
฿3,496
฿3,944 total
24 Sept - 25 Sept
includes taxes & fees
Hampton Inn Cape Girardeau I 55 East
Hotel 7 Inn Anna

Hotel 7 Inn Anna

100 Richview Dr Anna IL
Get rates
6.6/10 (241 reviews)
Hotel 7 Inn Anna

Frequently asked questions

Where is the best place to stay in Mill Creek?
Drury Plaza Hotel Cape Girardeau Conference Center, located 18.1 mi (29.2 km) from the heart of Mill Creek, is a top choice for your stay, based on our traveller data. Other good options for your visit to the area are The Riverview and Pear Tree Inn Cape Girardeau West. See all available top hotels, or vacation rentals in Mill Creek.
If I need to cancel my hotel reservation in Mill Creek, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Mill Creek.
What's it like to stay in Mill Creek?
Those travelling to Mill Creek will definitely enjoy the sights to see and things to do. There are 171 hotels and other accommodation options in the surrounding area. Find out more about Mill Creek.
What should I do while I'm visiting Mill Creek?
Places to visit in the wider area include Trail of Tears State Park, Century Casino & Hotel Cape Girardeau and Hunter Valley Winery. You'll also find Lower Cache River Access Area and Henry N Barkhausen Cache River Wetlands Center in the area. Take a look at what more there is to see and do in Expedia's Mill Creek guide.
What's the weather like in Mill Creek?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 4°C. Average annual precipitation for Mill Creek is 1431 mm.

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