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Check prices for these dates

Next weekend
23 Oct - 25 Oct
In two weeks
30 Oct - 1 Nov

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Our top choices for Illinois Medical District hotels

A modern indoor pool area with lounge chairs, a wooden table, and large windows.

1. Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC
2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (806 reviews)
"Great place to stay!!"
United States
Bobby
The price is ฿6,222
฿7,397 total
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn & Suites Chicago Medical District UIC
A spacious living area with a pool table, comfortable seating, a fireplace, and large windows.

2. Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District
3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1,502 reviews)
"Love the service and the hotel!"
United States
Elis
The price is ฿6,050
฿7,193 total
includes taxes & fees
25 Oct - 26 Oct
Hyatt Place Chicago Medical/University District
A grand hotel facade with classical architecture, featuring tall columns, ornate detailing, and a prominent entrance with a marquee.

3. Hyatt House Chicago Medical/University District

Hyatt House Chicago Medical/University District
3.5 star property
Illinois Medical District
9.2 out of 10, Wonderful, (1,626 reviews)
"Wonderful location."
United States
Andrea
The price is ฿7,654
฿9,100 total
includes taxes & fees
1 Nov - 2 Nov
Hyatt House Chicago Medical/University District
A rooftop lounge with a city view, featuring a sofa, tables, and a fire feature.

4. Hyatt House Chicago/West Loop-Fulton Market

Hyatt House Chicago/West Loop-Fulton Market
3.5 star property
2.3 km from Illinois Medical District
9.0 out of 10, Wonderful, (1,309 reviews)
"Location was amazing. Loved the outdoor market in walking distance"
United States
Georgianna
The price is ฿6,518
฿7,749 total
includes taxes & fees
1 Nov - 2 Nov
Hyatt House Chicago/West Loop-Fulton Market
A rooftop terrace with outdoor seating, a view of the city skyline, and a river.

5. LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton
4.5 star property
The Loop, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (3,878 reviews)
"It was a very nice stay! We enjoyed the hotel The views were amazing"
United States
James
The price is ฿7,330
฿9,709 total
includes taxes & fees
15 Nov - 16 Nov
LondonHouse Chicago, Curio Collection by Hilton
A hotel room with two beds, a nightstand, a telephone, and a wall with printed text.

6. Hilton Vacation Club Hotel Blake Chicago

Hilton Vacation Club Hotel Blake Chicago
4.0 star property
The Loop, 3.8 km from Illinois Medical District
9.6 out of 10, Exceptional, (1,221 reviews)
"Great location!"
United States
Mario
The price is ฿5,744
฿6,829 total
includes taxes & fees
3 Nov - 4 Nov
Hilton Vacation Club Hotel Blake Chicago
A restaurant with wooden tables and chairs, large windows, and a green vine-covered ceiling.

7. Hyatt Place Chicago/River North

Hyatt Place Chicago/River North
3.5 star property
River North, 4.4 km from Illinois Medical District
9.2 out of 10, Wonderful, (1,921 reviews)
"Great location!"
United States
Nilofar
The price is ฿5,816
฿6,914 total
includes taxes & fees
12 Nov - 13 Nov
Hyatt Place Chicago/River North
The Riu Plaza Chicago Hotel facade with a grand entrance, large windows, and a modern architectural design.

8. Hotel Riu Plaza Chicago

Hotel Riu Plaza Chicago
4.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.4 out of 10, Exceptional, (5,550 reviews)
"Excellent staff, excellent location, great resort style breakfast buffet"
United States
Scott E
The price is ฿6,187
฿8,308 total
includes taxes & fees
11 Nov - 12 Nov
Hotel Riu Plaza Chicago
A spacious bar area with high ceilings and large windows, offering views of a cityscape.

9. Hyatt Regency Chicago

Hyatt Regency Chicago
4.0 star property
The Loop, 4.8 km from Illinois Medical District
9.4 out of 10, Exceptional, (3,516 reviews)
"The hotel was beautiful, great location"
United States
Addison
The price is ฿8,824
฿11,683 total
includes taxes & fees
31 Oct - 1 Nov
Hyatt Regency Chicago
A modern restaurant interior with a green wall, hanging lights, and a long dining area.

10. Hotel 505 River North

Hotel 505 River North
4.5 star property
River North, 4.6 km from Illinois Medical District
9.2 out of 10, Wonderful, (2,964 reviews)
"Ideal location, excellent large rooms."
United Kingdom
Jordan
The price is ฿5,983
฿8,183 total
includes taxes & fees
15 Nov - 16 Nov
Hotel 505 River North
A multi-level atrium with a central spiral staircase, multiple seating areas, and a pool.

11. Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North
4.0 star property
River North, 4.7 km from Illinois Medical District
8.6 out of 10, Excellent, (5,989 reviews)
"I’d stay here again."
United States
Eliana
The price is ฿5,085
฿6,046 total
includes taxes & fees
1 Nov - 2 Nov
Embassy Suites by Hilton Chicago Downtown River North
A multi-story hotel with a prominent sign reading "Crowne Plaza."

12. Crowne Plaza Chicago West Loop by IHG

Crowne Plaza Chicago West Loop by IHG
3.5 star property
2.7 km from Illinois Medical District
9.0 out of 10, Wonderful, (2,737 reviews)
"Nice hotel and location was perfect."
United States
Chriselda
The price is ฿5,370
฿6,384 total
includes taxes & fees
1 Nov - 2 Nov
Crowne Plaza Chicago West Loop by IHG
The Intercontinental hotel facade with a large American flag and a floral display.

13. InterContinental Chicago Magnificent Mile by IHG

InterContinental Chicago Magnificent Mile by IHG
4.5 star property
Magnificent Mile, 4.9 km from Illinois Medical District
9.2 out of 10, Wonderful, (3,392 reviews)
"Great hotel"
United States
Said Lopez
The price is ฿7,086
฿9,594 total
includes taxes & fees
31 Oct - 1 Nov
InterContinental Chicago Magnificent Mile by IHG
An outdoor seating area with a fire pit, wooden benches, and tables, surrounded by large windows and string lights.

14. The Emily Hotel

The Emily Hotel
4.0 star property
2.8 km from Illinois Medical District
9.2 out of 10, Wonderful, (1,357 reviews)
"Great location!"
United States
Lori
The price is ฿7,848
฿9,331 total
includes taxes & fees
1 Nov - 2 Nov
The Emily Hotel
A person relaxing on a sofa with a window view of a building, a table with a glass of wine, and a vase with flowers.

15. L7 Chicago by LOTTE

L7 Chicago by LOTTE
4.5 star property
Theatre District, 4.5 km from Illinois Medical District
9.6 out of 10, Exceptional, (5,062 reviews)
"A fantastic A+ location in a well kept, boutique type hotel."
United States
Jeffrey Thomas
The price is ฿5,604
฿6,663 total
includes taxes & fees
1 Nov - 2 Nov
L7 Chicago by LOTTE
An indoor swimming pool with a glass ceiling, wooden walls, and seating areas.

16. Palmer House a Hilton Hotel

Palmer House a Hilton Hotel
4.0 star property
Theatre District, 4.2 km from Illinois Medical District
8.6 out of 10, Excellent, (2,715 reviews)
"Beautiful hotel with wonderful staff!"
United States
Christy
The price is ฿6,364
฿8,560 total
includes taxes & fees
31 Oct - 1 Nov
Palmer House a Hilton Hotel
A modern hotel with a glass facade, multiple floors, and a visible entrance.

17. Hyatt Place Chicago/Downtown - The Loop

Hyatt Place Chicago/Downtown - The Loop
3.0 star property
The Loop, 3.6 km from Illinois Medical District
8.8 out of 10, Excellent, (1,680 reviews)
"Great stay"
United States
Cordula
The price is ฿6,518
฿7,749 total
includes taxes & fees
1 Nov - 2 Nov
Hyatt Place Chicago/Downtown - The Loop
A hotel room with a large window offering a city view, a bed, a desk, and a chair.

18. Courtyard by Marriott Chicago Magnificent Mile

Courtyard by Marriott Chicago Magnificent Mile
3.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.0 out of 10, Wonderful, (2,086 reviews)
"Great location Staff was terrific"
United States
Richard
The price is ฿4,574
฿5,438 total
includes taxes & fees
1 Nov - 2 Nov
Courtyard by Marriott Chicago Magnificent Mile
A modern hotel with a glass facade, multiple floors, and a prominent sign.

19. Hampton Inn Chicago West Loop Fulton Market Area

Hampton Inn Chicago West Loop Fulton Market Area
2.5 star property
3.1 km from Illinois Medical District
9.2 out of 10, Wonderful, (1,006 reviews)
"Nice location, good breakfast Comfortable beds"
United States
Terri
The price is ฿7,099
฿8,440 total
includes taxes & fees
30 Oct - 31 Oct
Hampton Inn Chicago West Loop Fulton Market Area
A room with two chairs and a small table, a large window with a city view at night.

20. Eurostars Magnificent Mile

Eurostars Magnificent Mile
4.0 star property
River North, 4.8 km from Illinois Medical District
9.0 out of 10, Wonderful, (3,961 reviews)
"Fantastic stay"
United States
Will
The price is ฿4,813
฿5,722 total
includes taxes & fees
1 Nov - 2 Nov
Eurostars Magnificent Mile
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels recommended for families in Illinois Medical District

A spacious living area with a pool table, comfortable seating, a fireplace, and large windows.

Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District
3.0 star property
Near West Side
9.0 out of 10, Wonderful, (1,502)
The price is ฿6,050
฿7,193 total
includes taxes & fees
25 Oct - 26 Oct
Hyatt Place Chicago Medical/University District

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas for the activities you enjoy most.
A cityscape with tall skyscrapers and a historic tower.

Downtown Chicago

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

A busy urban street at dusk with tall buildings, a historic tower, and pedestrians.
Photo by © City of Chicago
Open Photo by © City of Chicago

Magnificent Mile

Shopaholics need look no further this glittering street packed with boutique and luxury shops, famous department stores and cafes.

A river with yellow boats, a bridge, and tall buildings.

The Loop

Bordered roughly by the surrounding elevated train circuit, this Chicago neighborhood has restaurants, galleries, parks and a giant silver bean.

A large, historic building with a central tower and multiple windows, located near a body of water.

River North

Known for its fantastic nightlife, stunning river views and popular shops, there's plenty to explore in River North. Top attractions like Merchandise Mart and Bally's Casino Chicago are major draws. Catch the metro at Merchandise Mart Station or Chicago Station (Brown Line) to see more of the city.

A river with a city skyline in the background, surrounded by green trees and grass.

Lincoln Park

Both a neighborhood and a park, this northern Chicago area has gorgeous scenery, residential streets lined with stately homes and extensive shopping and dining.

Top Illinois Medical District Hotel Reviews

River Hotel

River Hotel

10/10 Excellent
"The hotel was quite comfortable. Check-in was very smooth and amenities were all good. It wasn't a fancy room, but it was comfortable, clean, quiet and had a great view of the city. Great to relax after a long day touring around the city. Main attractions and restaurants are nearby. Overall, satisfied with the experience."
Karla 2-night trip
Posted less than an hour ago
River Hotel

Frequently asked questions

What's it like in Illinois Medical District?
Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighbourhood has to offer.
Where is the best place to stay in Illinois Medical District?
Based on Expedia customer reviews, Hampton Inn & Suites Chicago Medical District UIC is the highest ranked property in Illinois Medical District. This hotel is a short 15-minute walk from United Center, and it offers free breakfast and an indoor pool. Other top choices in the neighbourhood include Hyatt House Chicago Medical/University District and Hyatt Place Chicago Medical/University District.
How many hotels are there in the Illinois Medical District area?
If you're searching for places to stay in Chicago, choose from one of Expedia's 16 hotels and other accommodation options in Illinois Medical District.
If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, you might be able to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the top deals on offer in Illinois Medical District.
What can I see and do in this Chicago neighbourhood?
Don't miss favourite places to visit in the surrounding area, such as Soldier Field, United Center and Michigan Avenue. Malcolm X College and Michael Jordan Statue are also worth a visit when you're out sightseeing in Chicago.
How can I get around Illinois Medical District and the greater Chicago area?
Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.