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Check prices for these dates

Tonight
19 Jan - 20 Jan
Tomorrow
20 Jan - 21 Jan
This weekend
23 Jan - 25 Jan
Next weekend
30 Jan - 1 Feb

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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,002 reviews)
"Clean room , friendly staff , excellent location . Would stay again ! "
United States
Kathleen
The price is ฿12,705
฿14,293 total
includes taxes & fees
20 Jan - 21 Jan
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,001 reviews)
"Staff awesome, good breakfast great location"
United States
Carin helen
The price is ฿12,595
฿14,169 total
includes taxes & fees
20 Jan - 21 Jan
Orchid Key Inn - Adults Only
Exterior

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,001 reviews)
"Perfect place to stay. "
United States
Paulette
The price is ฿12,994
฿16,388 total
includes taxes & fees
27 Jan - 28 Jan
The Marquesa Hotel
Front of property

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (249 reviews)
"Awsome staff great location "
United States
Jeffrey
Key West Villas
Exterior

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (476 reviews)
"The Coco Plum Inn is a wonderful place to stay. Staff is fantastic and the location is perfect. We will definitely come back and stay at the Coco Plum Inn."
United States
Brent
The price is ฿11,295
฿12,708 total
includes taxes & fees
22 Jan - 23 Jan
Coco Plum Inn
Veranda Room | Terrace/patio

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (150 reviews)
"Large clean room and excellent staff! Made for a great stay. "
United States
Daniel
The price is ฿13,513
฿15,202 total
includes taxes & fees
20 Jan - 21 Jan
The Conch House Heritage Inn
Exterior

Douglas House

Douglas House
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (257 reviews)
"Loved the hotel will definitely stay again "
United States
Christina
The price is ฿6,195
฿7,666 total
includes taxes & fees
27 Jan - 28 Jan
Douglas House
Audubon Room - Adult Exclusive | Terrace/patio

The Mermaid & Alligator

The Mermaid & Alligator
3.5 star property
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (279 reviews)
"It is very quaint, clean, has a friendly atmosphere & has a great location. We love going there!"
United States
Bradley
The Mermaid & Alligator
11 Gecko's Garden - Adults Only | Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (369 reviews)
"Nice place to stay "
United States
yulio
The price is ฿11,061
฿13,230 total
includes taxes & fees
22 Jan - 23 Jan
Tropical Inn
Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (583 reviews)
"Great place!!"
United States
Joel
The price is ฿22,302
฿27,213 total
includes taxes & fees
25 Jan - 26 Jan
H2O Suites - Adults Only
Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,003 reviews)
"The staff was outstanding and this location was very convenient, yet located away from the hustle and bustle of the main area."
United States
William
The price is ฿12,551
฿14,119 total
includes taxes & fees
25 Jan - 26 Jan
Weatherstation Inn
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place! "
United States
David
The price is ฿9,405
฿11,257 total
includes taxes & fees
20 Jan - 21 Jan
Duval House
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (932 reviews)
"Great location "
United States
Scott
The price is ฿9,091
฿10,227 total
includes taxes & fees
20 Jan - 21 Jan
L'Habitation Guest House
Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,000 reviews)
"Excellent stay"
United States
Emily Barbara
The price is ฿11,618
฿13,070 total
includes taxes & fees
26 Jan - 27 Jan
Island City House Hotel
Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave | Free WiFi, bed sheets

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
3.5 star property
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (138 reviews)
"We absolutely loved finding this gem to stay on our first visit to Key West. Great location, wonderful staff, and excellent room. "
United States
Sammy
Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly
Front of property

Caribbean House

Caribbean House
3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (305 reviews)
"Great place to stay in the middle of key west"
United States
jerry
The price is ฿9,524
฿11,500 total
includes taxes & fees
22 Jan - 23 Jan
Caribbean House
2 outdoor pools, pool loungers

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,000 reviews)
"Great place to stay! Hope to come back!"
United States
Scott G.
The price is ฿18,842
฿23,320 total
includes taxes & fees
22 Jan - 23 Jan
Santa Maria Suites
Terrace/patio

Marrero's Guest Mansion

Marrero's Guest Mansion
3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (335 reviews)
"Location very good Staff friendly Pool not well maintained Breakfast and happy hour lacking compared to others"
United States
Scott
The price is ฿19,785
฿22,259 total
includes taxes & fees
21 Jan - 22 Jan
Marrero's Guest Mansion
3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,000 reviews)
"Great place to stay"
United States
Melody
The price is ฿9,064
฿10,197 total
includes taxes & fees
26 Jan - 27 Jan
Ambrosia Key West
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (425 reviews)
"Excellent food, location, friendly staff and pool was awesome."
United States
Karen
The price is ฿16,015
฿19,610 total
includes taxes & fees
26 Jan - 27 Jan
Ella's Cottages - Key West Historic Inns
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

Pier House Resort & Spa

10/10 Excellent
"The staff were all great, especially Colleen. She made our check-in and stay extra special. "
Carol Marie 6-night trip
Posted 3 days ago
Pier House Resort & Spa

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center which includes interior views

Florida Keys Eco - Discovery Center

4.3/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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Fort Zachary Taylor Park, Key West. State Park in Florida, USA., Shutterstock ID 761867707, Purchase Order: SP-1891 Wave 0, Client/Licensee: Hotels.com

Fort Zachary Taylor Historic State Park

4.4/5 (1,160 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1606 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveller data, and this B&B offers free breakfast and private balconies. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1606 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse and Key West Film Society if you're interested in local theatre.