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Tonight
11 Sep - 12 Sep
Tomorrow
12 Sep - 13 Sep
This weekend
11 Sep - 13 Sep
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18 Sep - 20 Sep

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
John
฿5,391
฿6,065 total
includes taxes & fees
14 Sept - 15 Sept
Almond Tree Inn Hotel - Adults Only

2. The Gardens Hotel

The Gardens Hotel
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Jason
฿5,559
฿6,254 total
includes taxes & fees
21 Sept - 22 Sept
The Gardens Hotel

3. The Marquesa Hotel

The Marquesa Hotel
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
LISA
฿6,363
฿9,021 total
includes taxes & fees
28 Sept - 29 Sept
The Marquesa Hotel

4. Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
United States
Nicholas
฿5,391
฿6,065 total
includes taxes & fees
14 Sept - 15 Sept
Orchid Key Inn - Adults Only

5. H2O Suites - Adults Only

H2O Suites - Adults Only
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
United States
Kourosh
฿9,242
฿12,633 total
includes taxes & fees
13 Sept - 14 Sept
H2O Suites - Adults Only

6. Douglas House - Adults Only

Douglas House - Adults Only
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
United States
michael
฿3,904
฿4,831 total
includes taxes & fees
29 Sept - 30 Sept
Douglas House - Adults Only

7. Island City House Hotel

Island City House Hotel
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Paul
฿5,093
฿5,730 total
includes taxes & fees
13 Sept - 14 Sept
Island City House Hotel

8. Duval House

Duval House
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Robert
฿3,272
฿4,392 total
includes taxes & fees
20 Sept - 21 Sept
Duval House

9. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
United States
Alissa
฿3,737
฿5,032 total
includes taxes & fees
13 Sept - 14 Sept
The Grand Guesthouse

10. Santa Maria Suites

Santa Maria Suites
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
United States
June Young
฿9,242
฿12,633 total
includes taxes & fees
13 Sept - 14 Sept
Santa Maria Suites

11. Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
United States
Mark
฿4,614
฿9,384 total
includes taxes & fees
27 Sept - 28 Sept
Southernmost House - Adult Exclusive

12. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
United States
Shawn
฿2,647
฿5,209 total
includes taxes & fees
13 Sept - 14 Sept
Silver Palms Inn & Historic Homes

13. Ambrosia Key West

Ambrosia Key West
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United Kingdom
Kate
฿4,447
฿5,003 total
includes taxes & fees
27 Sept - 28 Sept
Ambrosia Key West

14. Coco Plum Inn

Coco Plum Inn
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
United States
Jake
฿4,447
฿5,003 total
includes taxes & fees
14 Sept - 15 Sept
Coco Plum Inn

15. Weatherstation Inn

Weatherstation Inn
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
United States
Svetlana
฿5,598
฿6,298 total
includes taxes & fees
14 Sept - 15 Sept
Weatherstation Inn

16. Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Susannah
฿6,625
฿9,131 total
includes taxes & fees
13 Sept - 14 Sept
Ella's Cottages - Key West Historic Inns

17. Marrero's Guest Mansion

Marrero's Guest Mansion
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
United States
Michael
฿7,255
฿8,162 total
includes taxes & fees
23 Sept - 24 Sept
Marrero's Guest Mansion

18. Authors of Key West Guest House

Authors of Key West Guest House
The Meadows, 1.8 km from Florida Keys National Marine Sanctuary
United States
Idamis
฿2,460
฿2,767 total
includes taxes & fees
28 Sept - 29 Sept
Authors of Key West Guest House

19. Heron House - Adult Only

Heron House - Adult Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Natalia
฿3,854
฿5,438 total
includes taxes & fees
13 Sept - 14 Sept
Heron House - Adult Only

20. Alexander Palms Court

Alexander Palms Court
Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary
United States
Andrew
฿4,685
฿5,271 total
includes taxes & fees
13 Sept - 14 Sept
Alexander Palms Court
View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA
Almond Tree Inn Hotel - Adults Only
10.0
Exceptional
1,000 reviews
View
Exterior detail
The Gardens Hotel
9.8
Exceptional
1,000 reviews
View
Exterior
The Marquesa Hotel
9.8
Exceptional
1,000 reviews
View
Property grounds
Orchid Key Inn - Adults Only
9.8
Exceptional
1,000 reviews
View
Deluxe Suite, 1 King Bed, Personal Plunge Pool | View from room
H2O Suites - Adults Only
9.8
Exceptional
652 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

8/10 Good
"No fresh coffee at a Resort Hotel is preposterous. A select few of the staff choose to be rude to patrons, which is odd as most are great."
Michael 6-night trip
Posted 2 hours ago
Opal Key Resort & Marina, Key West
Southwinds Motel

Southwinds Motel

10/10 Excellent
"Great property and the staff very helpful and friendly."
Michael 5-night trip
Posted 7 hours ago
Southwinds Motel
The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

10/10 Excellent
"Excellent spot to stay right off Duval street...authentic Key West vibe"
kevin 1-night trip
Posted 8 hours ago
The Cabana Inn Key West - Adults Only
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"It was close to everything! Justin at the front desk and the lady that rented us the golf cart were amazing!"
Georgia 3-night trip
Posted 10 hours ago
Southernmost Beach Resort and Guesthouses
Winslow's Bungalows - Key West Historic Inns

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent
"Very nice room. Bed was very comfortable. Property offered privacy even though rooms and bungalows were very close together. Bungalow bar was great. Food and drinks were great. Had to ask to have room cleaned. 45$ per day amenities fee seemed excessive. Amenities should be part of room rate."
Stacy C. 4-night trip
Posted 11 hours ago
Winslow's Bungalows - Key West Historic Inns
Pier House Resort & Spa

Pier House Resort & Spa

10/10 Excellent
"What a great resort! Everything you need from a beach resort and more. The beautiful beach with NO sargassum. Clean, well maintained pool and common areas. Friendly staff. Delicious food and drinks. One of the best places I've ever stayed."
Nuran 3-night trip
Posted 23 hours ago
Pier House Resort & Spa
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

10/10 Excellent
"Love the history of La Concha, the vibe, bar, size and the location, almost mid-way on Duval Street, the hub of activity. It’s also one of the stops on the “hop-on hop-off “(every 30min) Old Town Trolley Key West Tours, which is a really big deal. There are no doubt other excellent properties in Key West, but La Concha was a great fit for me. I will definitely stay there on my next trip to the island."
Bonnie Gayle 5-night trip
Posted 1 day ago
La Concha Key West, Autograph Collection
Caribbean House

Caribbean House

10/10 Excellent
"Ashley is the best! Caribbean House is home away from home."
Richard 1-night trip
Posted 2 days ago
Caribbean House
Duval House

Duval House

10/10 Excellent
"Cold rooms!"
Joshua 4-night trip
Posted 3 days ago
Duval House

Other attractions near Florida Keys National Marine Sanctuary

A yellow exhibit labeled 'NOAA's AQUARIUS UNDERSEA LAB' with a circular window and a door.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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A brick corridor with arched ceilings and benches.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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A wooden signpost with directional arrows pointing to various cities and their distances.
Photo by Martin Pettersson

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)
You can learn about the history of Key West with a trip to Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.
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Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.
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USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.
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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.
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We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1495 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and Pier House Resort & Spa.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1495 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse and Coffee Butler Amphitheater if you're interested in local theatre.