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Check prices for these dates

This weekend
22 May - 24 May
Next weekend
29 May - 31 May

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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,015 reviews)
"Great staff, breakfast and happy hour. "
United States
Tina
The price is ฿7,418
฿8,345 total
includes taxes & fees
25 May - 26 May
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,007 reviews)
"This is an amazing place ! If you are coming to Key West you won’t find a nicer place. "
United States
Vicki
The price is ฿7,207
฿8,107 total
includes taxes & fees
25 May - 26 May
Orchid Key Inn - Adults Only
Exterior detail

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,004 reviews)
"Hands down the nicest rental my wife and I have ever stayed at. The proximity to every spot you want to be is amazing, the breakfast was perfect, and the staff went above and beyond after I made a stupid booking mistake."
United States
Salvatore
The price is ฿8,504
฿9,567 total
includes taxes & fees
10 Jun - 11 Jun
The Gardens Hotel
Front of property

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (261 reviews)
"This was the best place we have stayed at in Key West! It was super quiet but only a block from Duval. The owners really put a lot of care into the place and are super nice! Definitely would stay there again! "
United States
Jennifer
The price is ฿7,286
฿8,197 total
includes taxes & fees
26 May - 27 May
Key West Villas
Restaurant

Artist House Key West

Artist House Key West
3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (438 reviews)
"Great atmosphere and location."
United States
NATHAN
The price is ฿6,111
฿6,875 total
includes taxes & fees
28 May - 29 May
Artist House Key West
Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (956 reviews)
"Defiantly would stay again and so close to everything"
United States
kelly
The price is ฿6,470
฿7,279 total
includes taxes & fees
20 May - 21 May
Simonton Court Historic Inn & Cottages
Exterior

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (387 reviews)
"Great location, helpful staff and fun people. Would stay here again…the pool and room were fantastic"
United States
Scott
The price is ฿5,830
฿7,214 total
includes taxes & fees
2 Jun - 3 Jun
Douglas House - Adults Only
Exterior

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,005 reviews)
"Great accommodations and great staff"
United States
Julian
The price is ฿9,396
฿12,400 total
includes taxes & fees
16 Jun - 17 Jun
The Marquesa Hotel
Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,001 reviews)
"Perfect stay!"
United States
A. Elise
The price is ฿6,470
฿7,279 total
includes taxes & fees
21 May - 22 May
Weatherstation Inn
11 Gecko's Garden - Adults Only | Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (403 reviews)
"Very friendly staff and a prime location."
United States
Akhenaton
The price is ฿5,716
฿7,244 total
includes taxes & fees
21 May - 22 May
Tropical Inn
Veranda Room | Terrace/patio

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (174 reviews)
"Great location "
United Kingdom
Lucy
The price is ฿8,115
฿9,130 total
includes taxes & fees
9 Jun - 10 Jun
The Conch House Heritage Inn
Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (605 reviews)
"This resort was in the perfect location for exploring Key West. Highly recommend!"
United States
Barton
The price is ฿11,721
฿15,390 total
includes taxes & fees
2 Jun - 3 Jun
H2O Suites - Adults Only
Exterior

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (531 reviews)
"Loved the property and staff was super friendly."
United States
Brinkley
The price is ฿8,598
฿9,673 total
includes taxes & fees
25 May - 26 May
Coco Plum Inn
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (981 reviews)
"This was a lovely well stocked, and comfortable stay."
United States
Pat
The price is ฿4,748
฿5,341 total
includes taxes & fees
26 May - 27 May
L'Habitation Guest House
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,043 reviews)
"Nice place clean, good breakfast right on Duval for easy walk to everything "
Canada
Parmjit
The price is ฿5,495
฿6,881 total
includes taxes & fees
31 May - 1 Jun
Duval House
Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,001 reviews)
"Nice location "
United States
Michael
The price is ฿7,475
฿8,409 total
includes taxes & fees
2 Jun - 3 Jun
Island City House Hotel
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers

Ella's Cottages - Key West Historic Inns

Ella's Cottages - Key West Historic Inns
3.5 star property
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (475 reviews)
"Cute place. Great location to everything on Duval. Service was great and friendly."
United States
DJS Darren Jay
The price is ฿6,701
฿9,185 total
includes taxes & fees
25 May - 26 May
Ella's Cottages - Key West Historic Inns
Front of property

Caribbean House

Caribbean House
3.0 star property
Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary
9.0 out of 10, Wonderful, (361 reviews)
"Had a wonderful stay"
Canada
Jeff
The price is ฿4,635
฿6,027 total
includes taxes & fees
20 May - 21 May
Caribbean House
2 outdoor pools, pool loungers

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,007 reviews)
"Great hotel and room. Very clean, great location."
United States
Cindy
The price is ฿10,089
฿13,554 total
includes taxes & fees
27 May - 28 May
Santa Maria Suites
Property grounds

Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,009 reviews)
"Great location walking distance to everything Key West has to offer! "
United States
John
The price is ฿5,767
฿7,951 total
includes taxes & fees
31 May - 1 Jun
Paradise Inn Key West - Adults Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Almond Tree Inn Hotel - Adults Only
3.5 star property
10.0
Exceptional
1,015 reviews
View
Property grounds
Orchid Key Inn - Adults Only
3.5 star property
9.8
Exceptional
1,007 reviews
View
Exterior detail
The Gardens Hotel
4.0 star property
9.8
Exceptional
1,004 reviews
View
Front of property
Key West Villas
3.5 star property
9.8
Exceptional
261 reviews
View
Restaurant
Artist House Key West
3.5 star property
9.8
Exceptional
438 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Pier House Resort & Spa

Pier House Resort & Spa

4/10 Poor
"The Pier House used to be the best hotel in Key West. Not anymore. It was run down, the front desk and bar staff were not friendly or helpful, the room was musty, the beach area was dirty and not maintained. It is time for an overhaul of this once fabulous hotel. Very disappointed."
George 3-night trip
Posted 13 hours ago
Pier House Resort & Spa

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1554 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Opal Key Resort & Marina, Key West.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1554 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.