Search Hotels in Downtown, Seneca

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Downtown hotels

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
8.6 km from Downtown
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay. "
United States
Gene
The price is ฿3,429
฿4,256 total
includes taxes & fees
19 Jan - 20 Jan
Lakeside Lodge Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
11.8 km from Downtown
8.2 out of 10, Very good, (1,001 reviews)
"Clean room and staff were great’"
United States
Audrey
The price is ฿2,914
฿3,235 total
includes taxes & fees
21 Jan - 22 Jan
Best Western Plus Clemson Hotel & Conference Center

Comfort Suites Anderson-Clemson

Comfort Suites Anderson-Clemson
2.5 star property
25.3 km from Downtown
8.4 out of 10, Very good, (1,002 reviews)
"Everything was Great very friendly people "
United States
jose
The price is ฿3,510
฿3,897 total
includes taxes & fees
20 Jan - 21 Jan
Comfort Suites Anderson-Clemson

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
15.2 km from Downtown
9.8 out of 10, Exceptional, (792 reviews)
"Clean room, great location, wonderful staff!"
United States
Joyce
The price is ฿4,687
฿5,202 total
includes taxes & fees
19 Jan - 20 Jan
The Inn at Patrick Square

Inn @ Clemson

Inn @ Clemson
2.5 star property
11.6 km from Downtown
8.2 out of 10, Very good, (1,002 reviews)
"Love this hotel. It’s a little home away from home for me ❤️❤️❤️"
United States
Stacey
Inn @ Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
2.2 km from Downtown
9.2 out of 10, Wonderful, (671 reviews)
"Great place to stay"
United States
Jose
The price is ฿3,733
฿4,106 total
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn & Suites Seneca-Clemson Area

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
3.0 star property
10.3 km from Downtown
9.6 out of 10, Exceptional, (964 reviews)
"Great place to stay!"
United States
Mindi
The price is ฿4,687
฿5,202 total
includes taxes & fees
19 Jan - 20 Jan
Clemson University's James F. Martin Inn

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
1.7 km from Downtown
8.4 out of 10, Very good, (645 reviews)
"The stay was amazing "
United States
Tabatha
The price is ฿2,914
฿3,206 total
includes taxes & fees
25 Jan - 26 Jan
Best Western Seneca-Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
24.8 km from Downtown
8.2 out of 10, Very good, (1,001 reviews)
"Room was clean, front desk people were very nice. "
United States
Caressa
The price is ฿2,380
฿2,641 total
includes taxes & fees
21 Jan - 22 Jan
Microtel Inn & Suites by Wyndham Anderson/Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
8.3 km from Downtown
9.2 out of 10, Wonderful, (803 reviews)
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is ฿3,302
฿3,632 total
includes taxes & fees
25 Jan - 26 Jan
Tru by Hilton Seneca Clemson

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
11.7 km from Downtown
8.2 out of 10, Very good, (1,001 reviews)
"Clean room. Friendly staff. Convenient location."
United States
Anita
The price is ฿2,968
฿3,294 total
includes taxes & fees
25 Jan - 26 Jan
Comfort Inn & Suites Clemson - University Area

Country Inn & Suites by Radisson, Anderson, SC

Country Inn & Suites by Radisson, Anderson, SC
2.5 star property
25.2 km from Downtown
8.4 out of 10, Very good, (1,000 reviews)
"Everything was clean and breakfast was a nice spread. "
United States
Sheri
The price is ฿3,652
฿4,054 total
includes taxes & fees
24 Jan - 25 Jan
Country Inn & Suites by Radisson, Anderson, SC

Rodeway Inn Anderson North - Clemson

Rodeway Inn Anderson North - Clemson
2.0 star property
25.5 km from Downtown
7.8 out of 10, Good, (321 reviews)
"Room was spotless an the stay was great."
United States
Benito
The price is ฿2,045
฿2,269 total
includes taxes & fees
19 Jan - 20 Jan
Rodeway Inn Anderson North - Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
10.6 km from Downtown
9.8 out of 10, Exceptional, (749 reviews)
"Awesome hotel and very convenient for visiting Clemson."
United States
Nina
The price is ฿5,630
฿6,250 total
includes taxes & fees
19 Jan - 20 Jan
The Shepherd Hotel Downtown Clemson

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson
2.0 star property
25.6 km from Downtown
7.8 out of 10, Good, (1,005 reviews)
"Very nice we'll stay there again"
United States
Michael
The price is ฿1,979
฿2,196 total
includes taxes & fees
20 Jan - 21 Jan
Days Inn by Wyndham Anderson

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
2.5 star property
9.8 km from Downtown
8.8 out of 10, Excellent, (625 reviews)
"great place to stay"
United States
Edye
The price is ฿3,449
฿3,828 total
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn Clemson-University Area

Fairfield Inn & Suites by Marriott Anderson Clemson

Fairfield Inn & Suites by Marriott Anderson Clemson
2.5 star property
25 km from Downtown
9.0 out of 10, Wonderful, (567 reviews)
"Clean room staff was verynice!"
United States
Laura Jo
The price is ฿2,647
฿2,938 total
includes taxes & fees
1 Feb - 2 Feb
Fairfield Inn & Suites by Marriott Anderson Clemson

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
10.1 km from Downtown
9.6 out of 10, Exceptional, (560 reviews)
"Great stay"
United States
Megan
The price is ฿4,501
฿4,996 total
includes taxes & fees
19 Jan - 20 Jan
The Abernathy of Clemson

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
29.6 km from Downtown
7.0 out of 10, Good, (894 reviews)
"Bueno was "
Mexico
Alejandro
The price is ฿1,577
฿1,751 total
includes taxes & fees
27 Jan - 28 Jan
Quality Inn Clemson near University

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
25 km from Downtown
9.0 out of 10, Wonderful, (586 reviews)
"It was great. Room was clean and staff was friendly. "
United States
Veronica
The price is ฿3,240
฿3,596 total
includes taxes & fees
24 Jan - 25 Jan
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Downtown

Find the best Downtown areas for the activities you enjoy most.

Serenity Bay

When in Serenity Bay, you can plan a visit to Keowee Key Golf Course and Lake Keowee, some noteworthy sights in the nearby area.

Pine Ridge Point

If you're looking for some top things to see and do in Pine Ridge Point and surrounding area, you can visit South Beach and Lake Keowee.

Indian Oaks

While Indian Oaks may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Oconee County Library Seneca Branch and Seneca Historic District.

Keowee Plantation

While Keowee Plantation isn't home to many top sights, Seneca Historic District and Keowee Reservoir are some notable places to visit nearby.

Top Downtown Hotel Reviews

Frequently asked questions

What is Downtown like?
Travellers to the Downtown neighbourhood in Seneca will be sure to enjoy their stay. Make sure that you visit Seneca Historic District and Bertha Lee Strickland Cultural Museum as part of your Downtown travel plans.
Where is the best place to stay in Downtown?
Based on Expedia customer reviews, Quality Inn Seneca Clemson Area US-123 is the highest ranked property in Downtown. This hotel offers free breakfast and free parking.
How many hotels will I be able to find in Downtown?
Expedia has 9 Downtown hotels and other accommodation options, and one might make a good home base for venturing out into the greater Seneca area.
If I need to cancel my hotel reservation in Downtown, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your check-in date. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals in Downtown.
What can I see and do in this Seneca neighbourhood?
Seneca Historic District, Bertha Lee Strickland Cultural Museum and Oconee County Library Seneca Branch are just a few attractions to check out in Downtown. As you're discovering the neighbourhood, The Gauntlet and Seneca City Hall are some other places worth a visit. Golden Corner Plaza, Oconee Community Theatre and Applewood Shopping Center are just a few of the places to visit in and around Downtown. While you're out sightseeing in Seneca, make sure that you visit other sights such as Wyndham Plaza or Cross Creek Plantation Golf.