Photo by Alice Burghart

Find hotels in Cape Girardeau, MO from ฿2,004

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
6 Jan - 7 Jan
Tomorrow
7 Jan - 8 Jan
This weekend
9 Jan - 11 Jan
Next weekend
16 Jan - 18 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Cape Girardeau hotels

Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1001)
"This is one of the best properties. We are in the area often, it's the best."
United States
James
The price is ฿2,807
฿3,167 total
includes taxes & fees
5 Feb - 6 Feb
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Breakfast was very good and staff was extremely friendly and rooms were very clean "
United States
Rex
The price is ฿2,964
฿3,344 total
includes taxes & fees
1 Feb - 2 Feb
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Front of property
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1007)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is ฿2,183
฿2,463 total
includes taxes & fees
11 Jan - 12 Jan
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (477)
"Very nice hotel within walking distance to many good restaurants "
United States
Vicky
The price is ฿3,789
฿4,294 total
includes taxes & fees
25 Jan - 26 Jan
Courtyard by Marriott Cape Girardeau Downtown
Lobby
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
The price is ฿3,300
฿3,723 total
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn Cape Girardeau I 55 East
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (148)
"Lovely staff clean hotel comfortable beds "
United States
Kastriot
The price is ฿2,756
฿3,109 total
includes taxes & fees
25 Jan - 26 Jan
Fairfield Inn & Suites by Marriott Cape Girardeau
Free daily buffet breakfast
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1012)
"Awesome stay!"
United States
Breckin
The price is ฿2,807
฿3,167 total
includes taxes & fees
5 Feb - 6 Feb
Drury Inn & Suites Cape Girardeau
Lobby
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.2 out of 10, Good, (690)
"The room was clean and nice. The breakfast was really good."
United States
Kalani
The price is ฿1,854
฿2,092 total
includes taxes & fees
22 Jan - 23 Jan
Quality Inn Cape Girardeau North
Snack bar
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
The price is ฿2,799
฿3,186 total
includes taxes & fees
14 Jan - 15 Jan
Tru By Hilton Cape Girardeau
Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (484)
" Excellent stay. Will come again"
United States
joydeep
The price is ฿3,004
฿3,389 total
includes taxes & fees
5 Feb - 6 Feb
The Riverview
Exterior
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very good, (888)
"Room was clean and spacious."
United States
George
The price is ฿2,349
฿2,822 total
includes taxes & fees
25 Jan - 26 Jan
Candlewood Suites Cape Girardeau by IHG
Desk, free WiFi
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
The price is ฿1,716
฿2,004 total
includes taxes & fees
5 Feb - 6 Feb
Town House Inn Cape Giradreau
Free daily buffet breakfast
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1000)
"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."
United States
Colleen
The price is ฿2,183
฿2,485 total
includes taxes & fees
11 Jan - 12 Jan
Pear Tree Inn Cape Girardeau West
Lobby
Rockwood Inn

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
The price is ฿5,157
฿5,818 total
includes taxes & fees
5 Feb - 6 Feb
Rockwood Inn
Economy Single Room, 1 Queen Bed, Kitchenette | Free WiFi, bed sheets
Town House Inn

Town House Inn

Town House Inn
2.5 star property
Jackson
7.6 out of 10, Good, (428)
"The staff member Tim was very friendly and nice. "
United States
Julie
The price is ฿2,022
฿2,188 total
includes taxes & fees
8 Jan - 9 Jan
Town House Inn
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (682)
"Conveniently located, clean, friendly staff."
United States
Philip
The price is ฿2,625
฿2,841 total
includes taxes & fees
11 Jan - 12 Jan
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1005)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ฿2,589
฿2,737 total
includes taxes & fees
12 Jan - 13 Jan
Drury Inn & Suites Jackson MO
Lobby
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
2.5 star property
Jackson
8.2 out of 10, Very good, (740)
"Room was clean and affordable for one night. The morning person could have been more attentive to me being there for breakfast. No greeting at all and sat on her phone. I was the only one down in the breakfast area. Be more aware of her surroundings while working alone. "
United States
Lori
The price is ฿2,499
฿2,704 total
includes taxes & fees
11 Jan - 12 Jan
Comfort Suites Jackson-Cape Girardeau
Lobby sitting area
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
EC Reed's Mercantile and Hotel
Indoor pool, outdoor pool
Hotel 7 Inn Anna

Hotel 7 Inn Anna

Hotel 7 Inn Anna
2.5 star property
Anna
6.6 out of 10, (217)
"The staff was wonderful"
United States
Donna
The price is ฿2,491
฿2,890 total
includes taxes & fees
8 Jan - 9 Jan
Hotel 7 Inn Anna
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Cape Girardeau attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park

Riverfront Bridge Park

4.4/5 (74 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Learn more about Cape Girardeau

Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.

See all hotels in Cape Girardeau
Beautiful city by the Mississippi River
Photo by Alice Burghart
Open Photo by Alice Burghart

Top Cape Girardeau Hotel Reviews

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent
"Beautiful property and incredibly friendly staff!"
Jennifer 1-night trip
Posted 4 days ago
Fairfield Inn & Suites by Marriott Cape Girardeau

More cheap stays in Cape Girardeau

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO
The price is ฿2,183 per night from 11 Jan to 12 Jan
฿2,183
฿2,463 total
11 Jan - 12 Jan
includes taxes & fees
8.8/10 Excellent! (1,005 reviews)

Frequently asked questions

What's the best place to stay in Cape Girardeau?
Rockwood Inn is a favourite property for Expedia customers. This hotel offers free parking and free WiFi. Other favourite options based on traveller reviews include Fairfield Inn & Suites by Marriott Cape Girardeau and Courtyard by Marriott Cape Girardeau Downtown. See all available top hotels, or vacation rentals in Cape Girardeau.
If I need to cancel my hotel reservation in Cape Girardeau, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Cape Girardeau.
What's the best accommodation for a budget-friendly stay in Cape Girardeau?
Based on reviews, Pear Tree Inn Cape Girardeau Near the Medical Center is a popular hotel for our travellers in search of a less expensive place to stay, and it offers free Wi-Fi. Another top option for your stay on the cheap is Pear Tree Inn Cape Girardeau West. View all budget hotels in Cape Girardeau.
What's the best family accommodation in Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a hotel with an indoor pool and a restaurant, and it's a top choice on Expedia for families. Other good options for your family trip include Pear Tree Inn Cape Girardeau Near the Medical Center and Pear Tree Inn Cape Girardeau West. Also, attractions such as Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are fun for children of all ages. Find more child-friendly accommodations in Cape Girardeau.
What's the best LGBTQ-friendly hotel in Cape Girardeau?
Pear Tree Inn Cape Girardeau Near the Medical Center is a top LGBTQ-friendly hotel, and features free Wi-Fi and LCD TVs. Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Cape Girardeau.
What's the best dog-friendly hotel in Cape Girardeau?
Drury Plaza Hotel Cape Girardeau Conference Center is a top hotel for people travelling with their pets, and offers a restaurant and free WiFi for its human guests. Two other good options for you and your pet's trip include Drury Inn & Suites Cape Girardeau and Candlewood Suites Cape Girardeau by IHG. See more pet-friendly hotel accommodations in Cape Girardeau.
What are some accommodation options with pools in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top hotel with a pool, a full-service spa and free WiFi. View all hotels with pools in Cape Girardeau.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness centre. See all spa hotels in Cape Girardeau.
What is staying in Cape Girardeau like?
History buffs will enjoy exploring Cape Girardeau, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its riverfront, university setting and shopping. In Cape Girardeau, there are 58 hotels and other accommodation options to choose from. Find out more about Cape Girardeau.
What should I do while I'm visiting Cape Girardeau?
Families come for attractions such as Cape Splash Family Aquatic Center, Cape Girardeau Conservation Nature Center and Lazy L Safari Park. Landmarks like The Glenn House and Fort D Historic Site might be worth a visit. Natural beauty is on display at Shawnee National Forest, Mississippi River and Cape Rock Park. Take a look at what more there is to see and do in Expedia's Cape Girardeau guide.
What's the weather like in Cape Girardeau?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cape Girardeau is 1495 mm.