Stunning architecture and lush gardens create a serene atmosphere, surrounded by historic ruins and tropical plants. Indulge in the exceptional spa, savour delicious meals, and explore on-site museums for an unforgettable stay.
Located in Antigua Guatemala, Hotel Museo Spa Casa Santo Domingo is in the historical district. Santa Catalina Arch is a notable landmark, and the area's natural beauty can be seen at Central Park and Acatenango. House of the Giants and La Azotea Cultural Center are also worth visiting. Visit our Antigua Guatemala travel guide
3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez, 3001
What's nearby
Central Park
6 min walk - 0.6 km
Santa Catalina Arch
8 min walk - 0.7 km
Antigua Guatemala Cathedral
8 min walk - 0.7 km
Casa Santo Domingo Museum
1 min walk - 0.0 km
Las Capuchinas Convent
5 min walk - 0.4 km
Getting around
Guatemala City (GUA-La Aurora Intl.)
68 min drive
Restaurants
Clio’s Antigua
3 min walk
Cafe Condesa Express
3 min walk
Bar El Cabildo
1 min walk
7 Caldos Antigua Guatemala
1 min walk
Cafe Sol
1 min walk
About this property
Hotel Museo Spa Casa Santo Domingo
Luxury boutique hotel in the historical district
Close to Casa Santo Domingo Museum and Antigua Guatemala Cathedral, Hotel Museo Spa Casa Santo Domingo provides a poolside bar, a terrace and a garden. Indulge in a manicure/pedicure, aromatherapy and a massage at the on-site spa. At the two on-site restaurants, enjoy breakfast, lunch, dinner and Fusion cuisine. Enjoy the health club, as well as activities such as ziplining. In addition to a hair salon and dry cleaning/laundry services, guests can connect to free WiFi in public areas.
Other perks at this hotel include:
An outdoor pool
Free self-parking
Full breakfast (surcharge), a round-trip airport shuttle (surcharge) and an electric car charging station
Express check-out, luggage storage and a 24-hour front desk
Guest reviews say great things about the helpful staff and first-rate property condition
Room features
All 132 rooms offer comforts, such as fireplaces and premium bedding, as well as perks, such as pillow menus and air conditioning.
More conveniences in all rooms include:
Rollaway/extra beds (surcharge) and cots/infant beds (surcharge)
Does Hotel Museo Spa Casa Santo Domingo have a pool?
Yes, this property has an outdoor pool.
How much does it cost to stay at Hotel Museo Spa Casa Santo Domingo?
As of 23 Oct 2026, prices found for a 1-night stay for 2 adults at Hotel Museo Spa Casa Santo Domingo on 25 Oct 2026 start from ฿8,318, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
Is Hotel Museo Spa Casa Santo Domingo pet-friendly?
Yes, Hotel Museo Spa Casa Santo Domingo allows dogs (limit 1 total) with a maximum weight of up to 11 kg per pet. There's a fee of USD 61 per pet, per night. Some restrictions may apply, so please contact the property for more details.
How much is parking at Hotel Museo Spa Casa Santo Domingo?
Self-parking is free at this property.
What time is check-in at Hotel Museo Spa Casa Santo Domingo?
Check-in start time: 3:00 PM; check-in end time: midnight. Late check-in is available during limited hours.
What time is check-out at Hotel Museo Spa Casa Santo Domingo?
Checkout is at noon. Late checkout is available for a fee (subject to availability).
Does Hotel Museo Spa Casa Santo Domingo provide a shuttle to the airport?
Yes, there's an airport shuttle. A fee of USD 60 per person applies.
Where is Hotel Museo Spa Casa Santo Domingo located?
Located in Barrio de La Concepción, this luxury hotel is within a 10-minute walk of Casa Santo Domingo Museum, Central Park, and Antigua Guatemala Cathedral. Iglesia y Convento de Santo Domingo and Jade Maya Factory and Museum are just steps away.
Can I cancel my reservation for free and receive a full refund?
Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.
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Reviews
Hotel Museo Spa Casa Santo Domingo Reviews
9.4
Exceptional
All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
Absolutely spectacular hotel! A beautiful property with an amazing atmosphere and excellent facilities. It’s a bit pricey, but definitely worth the experience. I highly recommend taking advantage of the spa facilities, which were fantastic and one of the highlights of my stay. Highly recommended!
Room was supper clean and The staff helped with anything I needed . Breakfast was one of my favorite and the spa was perfect after doing a two day hike prior.
This hotel is unique and magnificent, built on the remains of a colonial times Dominican monastery, everything done with exquisite taste. The restaurant is five stars and there is an on-site spa and museums.
The place is the most luxurious hotel in Antigua. It has a museum, good food, exceptional rooms which invite you to rest.
The property exceeded our expectations.
A historic treasure in the heart of Antigua! Loved everything about my stay there. Beautiful rooms, restaurant food was delicious and moderately priced, helpful staff, we felt welcomed and cared for
One in a lifetime experiance, make sure to book a room with access to the spa and breakfast at their restaurant! Great location, at an amazing historical property!
Best hotel in Antigua. Beautifully maintained, staff is very nice and helpful and breakfast was delicious. The rooms are spacious and comfortable while staying true to the aesthetic of the property.
Love this place. Staff always very friendly and attentive. They maintain a very clean property, the rooms, the restaurant and the spa! The Sunday brunch is well worth it with a large selection of food. The spa is a must experience and highly recommend booking the rooms with spa access which makes it well worth it.
The best hotel experience I’ve ever had had. The staff was friendly and helpful. The property grounds were beautiful. And the food at the restaurant was delicious. We loved the spa so much we canceled our entire plans one day just to stay in at the hotel! Couldn’t have had a better stay.
Staff were exceptionally pleasant and helpful, the facilities are stunning, location is excellent, the room was a bit dark with limited view which was disappointing, and we had free access from room direct to spa but you could not lock this door so was of limited use . Breakfast buffet was superb
The room was clean, the hotel is on old ruins, the amenities are beautiful. The staff was not seen much and not as friendly as I would expect out of a hotel of this caliber. When compared to other local hotels, the facilities themselves are as good or better but the staff was not as friendly or helpful.
This is a hotel like no other in the world! Situated in a colonial city it was built around a ruin and made into a 5 star hotel! Any wise and knowledgeable traveler should stay in it and enjoy its different and beautiful settings as well as its service and food! Really excellent!
The photos on the website do not do this property justice. Large campus with large dining (website shows only a few tables.) We’ll be back—truly magical.
We had an absolute wonderful time at this hotel!!! We spent almost 3 hours just exploring the displays/museum of the hotel. It is a beautiful hotel, and the staff was beyond excellent and helpful. We loved the room which was like a mini apartment, that staff kept EXTRA clean, and enjoyed the morning/mid day coffee and treats that were put out for guests daily. We will definitely be staying here again for our return trip to Antigua.