The Best Hotels Closest to 21c Museum Hotel in Louisville - 2026 Updated Prices

Q: What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 267 hotels and other accommodation options you'll find within a mile.

Q: What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Homewood Suites by Hilton Louisville Downtown, KY .

Q: How many hotels are there near 21c Museum Hotel?

Expedia has 267 hotels and other accommodation options within a mile from 21c Museum Hotel.

Q: If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

Q: What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Our top choices for 21c Museum Hotel hotels

Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Shalahn

฿5,861 total

includes taxes & fees

19 Apr - 20 Apr

21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Kristin Woxland

฿5,896 total

includes taxes & fees

10 May - 11 May

The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Colin

฿5,854 total

includes taxes & fees

10 May - 11 May

Market Street Inn

2.1 km from 21c Museum Hotel

Roberta

฿6,708 total

includes taxes & fees

12 Apr - 13 Apr

Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

฿9,855 total

includes taxes & fees

12 Apr - 13 Apr

DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

juliet

฿5,312 total

includes taxes & fees

12 Apr - 13 Apr

Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Jack

฿5,607 total

includes taxes & fees

27 Apr - 28 Apr

Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Richard

฿6,062 total

includes taxes & fees

12 Apr - 13 Apr

Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Vic

฿4,393 total

includes taxes & fees

10 May - 11 May

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Emily

฿8,316 total

includes taxes & fees

19 Apr - 20 Apr

Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Judy

฿3,921 total

includes taxes & fees

10 May - 11 May

Louisville Marriott Downtown

Downtown Louisville, 0.7 km from 21c Museum Hotel

Peter

฿7,749 total

includes taxes & fees

3 May - 4 May

AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Holly

฿4,586 total

includes taxes & fees

10 May - 11 May

Aloft Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Lorene

฿4,662 total

includes taxes & fees

10 May - 11 May

Hyatt Regency Louisville

Downtown Louisville, 0.6 km from 21c Museum Hotel

Matthew

฿6,858 total

includes taxes & fees

13 Apr - 14 Apr

Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Gina

฿5,466 total

includes taxes & fees

11 May - 12 May

Seelbach Hilton Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Melisa

฿6,343 total

includes taxes & fees

4 May - 5 May

Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Paige

฿5,042 total

includes taxes & fees

12 Apr - 13 Apr

SpringHill Suites by Marriott Louisville Downtown

Downtown Louisville, 1 km from 21c Museum Hotel

Jordyn

฿4,775 total

includes taxes & fees

12 Apr - 13 Apr

Hampton Inn Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Joshua

฿4,297 total

includes taxes & fees

19 Apr - 20 Apr

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Homewood Suites by Hilton Louisville Downtown, KY	3.0 star property	9.4 Exceptional 1,001 reviews	View
21c Museum Hotel Louisville	4.5 star property	9.4 Exceptional 1,003 reviews	View
The Brown Hotel	4.5 star property	9.4 Exceptional 1,170 reviews	View
Market Street Inn	3.5 star property	9.8 Exceptional 120 reviews	View
Louisville Bourbon Inn	5.0 star property	10.0 Exceptional 22 reviews	View

Top 21c Museum Hotel Hotel Reviews

Radisson Hotel Louisville North

10/10 Excellent

"Yes"

Holiday Inn Louisville Downtown by IHG

6/10 Okay

"Breakfast isn't included in all stays, and is not prepared quickly. Parking is valet only, which requires a charge of $36/ day. This means you are paying for the privilege of waiting for your car as opposed to just walking to the car lot. The rooms were nice and decently clean. The staff were mostly friendly, but the night staff is noticeably more friendly than the day staff. "

The Grady

10/10 Excellent

"Wonderful hotel. The room and bathroom were clean and aesthetically pleasing. "Chance" helped us to our room and gave us an amazing history of the hotel. He was professional and friendly. The restaurant downstairs was ok. We were able to Uber to The Last Refuge, a converted church/bar. So cool. Make reservations though. The ONLY complaint I would have would be... A towel had orange stains on it, and a bathmat the next day had a big tear in it. Both were clean but should have just been discarded. I would stay there again ! "

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 267 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Homewood Suites by Hilton Louisville Downtown, KY.

How many hotels are there near 21c Museum Hotel?

Expedia has 267 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Search Hotels Near 21c Museum Hotel, Louisville

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for 21c Museum Hotel hotels

Homewood Suites by Hilton Louisville Downtown, KY

21c Museum Hotel Louisville

The Brown Hotel

Market Street Inn

Louisville Bourbon Inn

DuPont Mansion Bed & Breakfast

Cambria Hotel Louisville Downtown-Whiskey Row

Stellar Suites

Tempo By Hilton Louisville Downtown Nulu

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Moxy Louisville Downtown

Louisville Marriott Downtown

AC Hotel Louisville Downtown

Aloft Louisville Downtown

Hyatt Regency Louisville

Hotel Genevieve part of JdV by Hyatt

Seelbach Hilton Louisville Downtown

Central Park Bed & Breakfast

SpringHill Suites by Marriott Louisville Downtown

Hampton Inn Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Radisson Hotel Louisville North

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

Kentucky Center for the Performing Arts

Frequently asked questions