The Best Hotels Closest to 21c Museum Hotel in Louisville - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A covered outdoor seating area with wicker furniture and a wooden railing.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

฿9,238

฿10,723 total

includes taxes & fees

30 Aug - 31 Aug

A wooden staircase with a balustrade leading to a landing.

A brick building with a covered porch, columns, and potted plants.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A dining area with brick walls, wooden shelves, and tables set for a meal.

2. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

฿5,521

฿6,238 total

includes taxes & fees

30 Aug - 31 Aug

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Jasmine

฿6,445

฿7,583 total

includes taxes & fees

6 Sept - 7 Sept

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

4. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Brad

฿3,331

฿5,596 total

includes taxes & fees

1 Sept - 2 Sept

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

5. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

฿4,626

฿5,370 total

includes taxes & fees

30 Aug - 31 Aug

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand dining area with ornate ceiling, chandeliers, and a bar area with a sign reading "Cigar Bar".

6. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

Rachel

฿4,942

฿5,815 total

includes taxes & fees

4 Sept - 5 Sept

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A swimming pool with lounge chairs and a view of the city.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

7. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Jon

฿3,774

฿4,440 total

includes taxes & fees

6 Sept - 7 Sept

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A modern interior with a fireplace, bookshelves, and seating areas.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A lobby with a marble floor, a reception desk, and a large chandelier.

8. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Kara

฿6,589

฿7,753 total

includes taxes & fees

30 Aug - 31 Aug

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Breeana

฿5,675

฿6,677 total

includes taxes & fees

7 Sept - 8 Sept

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

10. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Candice

฿5,927

฿7,139 total

includes taxes & fees

2 Sept - 3 Sept

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern restaurant with high tables and booths, wooden ceiling panels, and framed pictures on the walls.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

11. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Maria

฿3,910

฿4,600 total

includes taxes & fees

3 Sept - 4 Sept

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A modern restaurant interior with a staircase, round tables, and a brick wall.

12. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Conswaila

฿5,438

฿6,399 total

includes taxes & fees

30 Aug - 31 Aug

An outdoor seating area with wicker furniture and a fire pit.

A modern living room with a sofa, armchairs, a coffee table, and a TV.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

A modern lounge area with seating, tables, and a view of the city through large windows.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Tina

฿3,208

฿3,775 total

includes taxes & fees

6 Sept - 7 Sept

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

14. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

David

฿4,027

฿4,739 total

includes taxes & fees

4 Sept - 5 Sept

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

15. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Nina

฿3,444

฿4,052 total

includes taxes & fees

6 Sept - 7 Sept

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

16. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Riley

฿3,376

฿3,972 total

includes taxes & fees

7 Sept - 8 Sept

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

17. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Angela

฿3,545

฿4,171 total

includes taxes & fees

6 Sept - 7 Sept

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A stone house with a balcony, a front door, and a staircase leading to the entrance.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Angie

฿4,352

฿5,051 total

includes taxes & fees

31 Aug - 1 Sept

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A balcony with a view of a river, a bridge, and a cityscape.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

19. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Jacob

฿4,735

฿5,571 total

includes taxes & fees

8 Sept - 9 Sept

A spacious lobby with a blue sofa, a wooden coffee table, and a chandelier.

An indoor swimming pool with clear water, surrounded by white marble walls and columns, and furnished with lounge chairs and tables.

A modern hotel room with a living area, a dining area, and a bedroom.

A hotel dining area with long tables, booths, and a bar.

20. Embassy Suites Louisville Downtown

Downtown Louisville, 0.8 km from 21c Museum Hotel

Spencer

฿4,317

฿5,079 total

includes taxes & fees

6 Sept - 7 Sept

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 124 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 499 reviews	View
Stellar Suites	9.6 Exceptional 147 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 146 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Bars were nice, rooms were clean and nice."

SpringHill Suites by Marriott Louisville Downtown

8/10 Good

"the view as I look out over the city ar night"

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Check in was super fast. The elevators were also lightning fast. The room was clean and had all the amenities you could need. The toiletries smelled amazing. The shower water pressure was great. The only two downsides were the street noise kept us up and the bed was somewhat uncomfortable."

Omni Louisville Hotel

10/10 Excellent

"Great place to be. Cost benefit is there. Building's sourrounding it's full of homeless tho. Be careful while walking"

The Grady

8/10 Good

"Front desk staff was very friendly and helpful. Facility was super clean and well kept. Room was clean, well appointed & decorated. Cleaning staff had left the AC on full tilt, so my wife loved that! Valet was a little slow, but I believe that was an outside contractor and they seemed understaffed, so not really the fault of the hotel. The only reason I knocked off one star was because of an overnight ruckus outside our room that unfortunately led to the police coming by the next morning and knocking on doors. Not sure if the hotel could have done anything at all to avoid the issue, but it was a detraction from our experience nonetheless."

Fairfield Inn & Suites by Marriott Louisville Downtown

10/10 Excellent

"Our entire stay was amazing. The front desk was very helpful and the breakfast was great! 10/10 would stay here again!"

Holiday Inn Express & Suites Louisville Downtown by IHG

10/10 Excellent

"The staff and breakfast"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

See properties

Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

See properties

A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

See properties

A wall of wooden baseball bats organized by size and weight.

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

See properties

Golden Statue of David

Find out about the history of Louisville when you spend time at Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your trip to Louisville. Stroll along the area's riverfront or experience its great live music.

See properties

Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

See properties

SAR Genealogical Research Library: NSSAR Library

You can spend time exploring the galleries in SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 293 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown by IHG.

How many hotels are there near 21c Museum Hotel?

Expedia has 293 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Search Hotels Near 21c Museum Hotel, Louisville

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Hotel Distil, Autograph Collection

4. Stellar Suites

5. DuPont Mansion Bed & Breakfast

6. The Brown Hotel

7. Homewood Suites by Hilton Louisville Downtown, KY

8. Omni Louisville Hotel

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10. 21c Museum Hotel Louisville

11. Tempo By Hilton Louisville Downtown Nulu

12. The Grady

13. Towneplace Suites By Marriott Louisville Downtown

14. AC Hotel Louisville Downtown

15. Moxy Louisville Downtown

16. Cambria Hotel Louisville Downtown-Whiskey Row

17. Aloft by Marriott Louisville Downtown

18. Central Park Bed & Breakfast

19. Galt House Hotel Trademark Collection by Wyndham

20. Embassy Suites Louisville Downtown

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

SpringHill Suites by Marriott Louisville Downtown

Homewood Suites by Hilton Louisville Downtown, KY

Omni Louisville Hotel

The Grady

Fairfield Inn & Suites by Marriott Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions