The Best Hotels Closest to 21c Museum Hotel in Louisville - 2026 Updated Prices

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A building entrance with a dark door, a large number '1332' above it, and two large potted ferns on either side.

A covered outdoor seating area with wicker furniture and a wooden railing.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

฿9,365

฿10,870 total

includes taxes & fees

20 Oct - 21 Oct

A wooden staircase with a balustrade leading to a landing.

A brick building with a covered porch, columns, and potted plants.

A dining area with brick walls, wooden shelves, and tables set for a meal.

A two-story brick building with a white porch and a sign reading "Hotel".

2. Market Street Inn

2.1 km from 21c Museum Hotel

Holly

฿7,423

฿8,388 total

includes taxes & fees

20 Oct - 21 Oct

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

A room with a red velvet sofa, a blue armchair, and a small round table with books.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

3. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

฿6,115

฿7,097 total

includes taxes & fees

25 Oct - 26 Oct

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

An outdoor dining area with tables and chairs, a green building facade, and a row of plants along the wall.

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

4. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

฿7,961

฿9,367 total

includes taxes & fees

29 Oct - 30 Oct

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

A grand lobby with ornate ceiling, large windows, and classic furniture.

5. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

John

฿4,214

฿4,958 total

includes taxes & fees

28 Oct - 29 Oct

A modern bar area with a circular bar, multiple seating options, and a large screen.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern interior with a central wooden table, refrigerated beverage dispensers, and shelves stocked with snacks and condiments.

6. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Gordon

฿3,424

฿4,029 total

includes taxes & fees

25 Oct - 26 Oct

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

7. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

Kelly

฿4,016

฿4,725 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A lobby with a marble floor, a reception desk, and a large chandelier.

A modern interior with a fireplace, bookshelves, and seating areas.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

8. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Samantha

฿4,411

฿5,190 total

includes taxes & fees

6 Nov - 7 Nov

A modern hotel lobby with a reception desk, seating area, and a staircase leading to the upper floor.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern KFC building with large glass windows, a prominent sign, and a well-lit entrance area.

9. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

฿3,882

฿6,259 total

includes taxes & fees

18 Oct - 19 Oct

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A multi-level interior with a staircase, bookshelves, and a prominent sign reading "THE GRADY".

A building with a sign reading "THE GRADY" at the entrance.

10. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

฿6,228

฿7,328 total

includes taxes & fees

26 Oct - 27 Oct

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

11. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

฿4,109

฿4,835 total

includes taxes & fees

25 Oct - 26 Oct

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

A cozy room with a geometric-patterned ceiling, a sofa, and a chair.

12. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

฿5,107

฿6,177 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with wicker furniture and a fire pit.

A modern hotel lobby with a large central table, multiple seating areas, and large windows offering city views.

A modern lounge area with seating, tables, and a view of the city through large windows.

An indoor swimming pool with clear water, a diving board, and lounge chairs around the pool area.

13. Towneplace Suites By Marriott Louisville Downtown

Downtown Louisville, 0.3 km from 21c Museum Hotel

Derek

฿3,256

฿3,831 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

A modern lobby with a central reception desk, seating area, and a large abstract wall art piece.

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

14. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Cameron

฿6,028

฿7,093 total

includes taxes & fees

26 Oct - 27 Oct

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern hotel with a prominent 'Marriott' sign, large windows, and a brick facade.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

15. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

฿3,404

฿4,005 total

includes taxes & fees

30 Oct - 31 Oct

An indoor dining area with wooden tables and chairs, a bar area, and a view of the street outside.

A modern bar area with sofas, tables, and a bar stocked with bottles.

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern coffee shop interior with a central island, wooden counter, and large windows.

16. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Dolores

฿4,310

฿5,071 total

includes taxes & fees

29 Oct - 30 Oct

A room with a checkered floor, leather armchairs, a sofa, and a small table with a glass. There are windows with arched tops and a view of buildings outside.

A yellow coffee shop counter with a menu board above, displaying various coffee and food items.

A bedroom with a bed, a chair, a TV, and a window with curtains.

A brightly lit grocery store with yellow shelving and a central checkout counter.

17. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

฿4,834

฿5,687 total

includes taxes & fees

26 Oct - 27 Oct

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A grand room with a fireplace, a staircase, and a chandelier.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

฿5,732

฿6,654 total

includes taxes & fees

25 Oct - 26 Oct

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern interior with a central seating area, a television screen, and a wooden partition with various items displayed.

19. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

฿4,813

฿5,663 total

includes taxes & fees

25 Oct - 26 Oct

A modern interior with large windows offering a city view, a circular light fixture, and leather seating.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Mark

฿4,859

฿5,717 total

includes taxes & fees

29 Oct - 30 Oct

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 125 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 149 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 510 reviews	View
The Brown Hotel	9.4 Exceptional 1,378 reviews	View

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent

"Amazing property, clean, close to downtown, excellent staff. Will highly recommend."

Cambria Hotel Louisville Downtown-Whiskey Row

10/10 Excellent

"The staff were very helpful & great location."

Louisville Marriott Downtown

8/10 Good

"room was very clean but the there were additional blankets provided"

Embassy Suites Louisville Downtown

10/10 Excellent

"The hotel is amazing! Great spa e, high ceilings, breakfast was great and filling. The room was so nice that I dreaded leaving the room. The staff was kind and courteous. I will be back just for the experience. Its near all sorts of entertainment."

Homewood Suites by Hilton Louisville Downtown, KY

10/10 Excellent

"Very comfortable place to stay and all the team was very nice!"

Econo Lodge Louisville Downtown

8/10 Good

"This is the second time I have stayed here. Very clean. The hairdryer in room stopped working and I called the front desk. I was very impressed by how fast they came to my room and took care of my needs. A+. Also, the room was Very clean. Great housekeeping. The only complaint I had was the vending machines kept my money and they were not working. Another guest on the floor had the same issue. I ended up walking across the street to a gas station for snacks and a drink. I would not advise walking in the night alone. Alot of homeless people begging for money. Not at the property though. I felt very safe at the property. I recommend this hotel and would stay again. Also breakfast area was also very clean. Fast check in as well."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Great overall place. Location very convenient too."

Courtyard by Marriott Louisville Downtown

8/10 Good

"wonderful location and service"

The Reserve on Main

10/10 Excellent

"All good."

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you spend time at Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your trip to Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend time exploring the galleries in SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 292 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels are there near 21c Museum Hotel?

Expedia has 292 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Search Hotels Near 21c Museum Hotel, Louisville

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

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Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. DuPont Mansion Bed & Breakfast

4. Hotel Distil, Autograph Collection

5. The Brown Hotel

6. Cambria Hotel Louisville Downtown-Whiskey Row

7. Homewood Suites by Hilton Louisville Downtown, KY

8. Omni Louisville Hotel

9. Stellar Suites

10. The Grady

11. Tempo By Hilton Louisville Downtown Nulu

12. 21c Museum Hotel Louisville

13. Towneplace Suites By Marriott Louisville Downtown

14. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

15. Moxy Louisville Downtown

16. Aloft by Marriott Louisville Downtown

17. Hotel Genevieve part of JdV by Hyatt

18. Central Park Bed & Breakfast

19. AC Hotel Louisville Downtown

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Cambria Hotel Louisville Downtown-Whiskey Row

Louisville Marriott Downtown

Embassy Suites Louisville Downtown

Homewood Suites by Hilton Louisville Downtown, KY

Econo Lodge Louisville Downtown

Aloft by Marriott Louisville Downtown

Courtyard by Marriott Louisville Downtown

The Reserve on Main

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions