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20 Dec - 21 Dec
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Our top choices for Louisville Science Center hotels

Interior entrance
Louisville Bourbon Inn

Louisville Bourbon Inn

Louisville Bourbon Inn
5.0 star property
Old Louisville, 2.9 km from Louisville Science Center
10.0 out of 10, Exceptional, (20)
"Great breakfast. Frittata, French toast, eggs, bacon, sausage, grapes, toast, biscuits and gravy - all were excellent. "
United States
Gaven
The price is ฿8,323
฿9,661 total
includes taxes & fees
23 Dec - 24 Dec
Louisville Bourbon Inn
Terrace/patio
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is ฿5,500
฿6,472 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Distil, Autograph Collection
Lobby
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1001)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is ฿4,551
฿5,355 total
includes taxes & fees
27 Dec - 28 Dec
The Grady
Interior entrance
Market Street Inn

Market Street Inn

Market Street Inn
3.5 star property
2.1 km from Louisville Science Center
9.8 out of 10, Exceptional, (120)
"I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice."
United States
Megan
The price is ฿5,819
฿6,575 total
includes taxes & fees
22 Dec - 23 Dec
Market Street Inn
Front of property
DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
3.0 star property
Old Louisville, 2.8 km from Louisville Science Center
9.8 out of 10, Exceptional, (97)
"Breakfast was wonderful, great place to stay!"
United States
Janie
The price is ฿4,486
฿5,207 total
includes taxes & fees
22 Dec - 23 Dec
DuPont Mansion Bed & Breakfast
Dining
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1002)
"Great facility. Darrel at the front desk was great!"
United States
John
The price is ฿2,990
฿3,518 total
includes taxes & fees
11 Jan - 12 Jan 2026
Cambria Hotel Louisville Downtown-Whiskey Row
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1154)
"Staff and breakfast was exceptional! "
United States
Alicia
The Brown Hotel
Lounge
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
East Market District, 2.2 km from Louisville Science Center
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is ฿3,706
฿5,942 total
includes taxes & fees
3 Jan - 4 Jan 2026
Stellar Suites
Terrace/patio
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.2 out of 10, Wonderful, (1002)
"The room was wonderful and the staff exceptional."
United States
Daniel
The price is ฿3,219
฿3,788 total
includes taxes & fees
9 Jan - 10 Jan 2026
Homewood Suites by Hilton Louisville Downtown, KY
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, < 0.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1004)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is ฿4,366
฿5,294 total
includes taxes & fees
1 Jan - 2 Jan 2026
21c Museum Hotel Louisville
Property amenity
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 0.3 km from Louisville Science Center
9.2 out of 10, Wonderful, (511)
"Accommodations were perfect. Staff excellent. Food was very good."
United States
Bennett
The price is ฿3,047
฿3,585 total
includes taxes & fees
8 Jan - 9 Jan 2026
Towneplace Suites By Marriott Louisville Downtown
3 bars/lounges, cocktail bar, lobby lounge
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.2 out of 10, Wonderful, (1742)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is ฿5,251
฿6,179 total
includes taxes & fees
1 Jan - 2 Jan 2026
Omni Louisville Hotel
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 2.1 km from Louisville Science Center
9.4 out of 10, Exceptional, (827)
"Clean, quiet and great location "
United States
Kristine
The price is ฿3,222
฿3,791 total
includes taxes & fees
5 Jan - 6 Jan 2026
Tempo By Hilton Louisville Downtown Nulu
Interior entrance
Moxy Louisville Downtown

Moxy Louisville Downtown

Moxy Louisville Downtown
3.5 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.2 out of 10, Wonderful, (699)
"Awesome location and the staff was super friendly"
United States
Kelly
The price is ฿3,047
฿3,585 total
includes taxes & fees
27 Dec - 28 Dec
Moxy Louisville Downtown
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 0.5 km from Louisville Science Center
9.0 out of 10, Wonderful, (3888)
"Great place to stay! "
United States
Rochelle
The price is ฿4,187
฿4,926 total
includes taxes & fees
26 Dec - 27 Dec
Galt House Hotel Trademark Collection by Wyndham
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.2 out of 10, Wonderful, (55)
"Lovely hotel in downtown Louisville. Well appointed room, comfy bed and outstanding dining. "
United States
Michelle
The price is ฿5,287
฿6,221 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville, 3 km from Louisville Science Center
9.4 out of 10, Exceptional, (56)
"Our stay here was excellent in every way! The owners were very sweet and went out of their way to assist us in every way, the rooms were very cozy, and the breakfasts were fantastic. This is the best B&B we've ever stayed."
United States
John
The price is ฿4,258
฿4,943 total
includes taxes & fees
22 Dec - 23 Dec
Central Park Bed & Breakfast
Lobby lounge
AC Hotel Louisville Downtown

AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
3.5 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (607)
"Everything was amazing, staff was wonderful "
United States
Ashley
The price is ฿3,209
฿3,776 total
includes taxes & fees
28 Dec - 29 Dec
AC Hotel Louisville Downtown
Terrace/patio
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1017)
"Great location and accommodations."
United States
Steve
The price is ฿3,989
฿4,693 total
includes taxes & fees
27 Dec - 28 Dec
Hotel Genevieve part of JdV by Hyatt
Reception
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.0 out of 10, Wonderful, (1116)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is ฿3,580
฿4,212 total
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Louisville Science Center Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"Very comfortable room. People were friendly. Good bartenders "
Marvin 3-night trip
Posted 2 days ago
Galt House Hotel Trademark Collection by Wyndham
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10/10 Excellent
"The hotel was beautiful and clean"
Shani 1-night trip
Posted 3 days ago
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotels near other Louisville Science Center attractions

Exploration of Louisville Slugger Museum in Downtown Louisville, Kentucky on a Sunny Day

Louisville Slugger Museum

4.5/5 (1,200 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
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A great stop! This has to be one of the best museums I’ve been about somebody! Great stop and a fantastic life!
Photo by Corey Dargan
Open Photo by Corey Dargan

Muhammad Ali Center

4.3/5 (298 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
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Frequently asked questions

What's the area like around Louisville Science Center?
Louisville Science Center is located in an area of Louisville known for its stunning river views, sporting events and great live music scene. If you're looking for a convenient place to stay, take a look at the 295 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Louisville Science Center?
Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and a 24-hour fitness centre. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.
How many hotels can I expect to find close to Louisville Science Center?
Expedia has 295 hotels and other accommodation options within a mile from Louisville Science Center.
If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?
Yes! Most hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to get the top deals on offer near Louisville Science Center.
What can I see and do near Louisville Science Center?
21c Museum Hotel, Louisville Slugger Museum and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can catch a show at Kentucky Center for the Performing Arts, Louisville Palace and Derby Dinner Playhouse.