Search Hotels in Zona 21, Guatemala City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Zona 21, Guatemala City

Reception hall
Barceló Guatemala City

Barceló Guatemala City

4.5 star property
Zona 9, 6.1 km from Zona 21
9.2 out of 10, Wonderful, (3101)
"Barcelo is a nice, clean and comfortable place to stay"
United States
Ana
The price is ฿2,119
฿2,585 total
includes taxes & fees
4 Jan - 5 Jan 2026
Barceló Guatemala City
3 outdoor pools, pool umbrellas
Hotel Soleil La Antigua

Hotel Soleil La Antigua

4.0 star property
20.9 km from Zona 21
8.6 out of 10, Excellent, (1001)
"Great room"
United States
Elvin
Hotel Soleil La Antigua
4 restaurants, breakfast, lunch, dinner served; international cuisine
InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG

5.0 star property
Zona 10, 6.4 km from Zona 21
9.2 out of 10, Wonderful, (1000)
"Very friendly staff and clean room"
United States
Julia
The price is ฿4,308
฿5,645 total
includes taxes & fees
5 Jan - 6 Jan 2026
InterContinental Real Guatemala by IHG
2 treatment rooms
Hotel Las Americas

Hotel Las Americas

4.0 star property
Zona 13, 5.1 km from Zona 21
8.4 out of 10, Very good, (1008)
"Excellent breakfast, nice room and nice view to the aurora airport "
Mexico
Ronald Fernando Rivera
Hotel Las Americas
Breakfast, lunch, dinner served; international cuisine, garden views
Clarion Suites Guatemala City

Clarion Suites Guatemala City

4.0 star property
Zona 10, 6.4 km from Zona 21
9.0 out of 10, Wonderful, (1005)
"My stay at this place was excellent "
United States
Diego
The price is ฿3,217
฿3,924 total
includes taxes & fees
25 Dec - 26 Dec
Clarion Suites Guatemala City
Fitness studio
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 star property
19.5 km from Zona 21
9.2 out of 10, Wonderful, (1013)
"Great room, the food was awesome and the amenities are just amazing."
United States
Cesar Luis Sinclair
The price is ฿7,595
฿9,655 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Museo Spa Casa Santo Domingo
Traditional Room | 1 bedroom, free WiFi
Casa 96

Casa 96

3.0 star property
Zona 13, 4.6 km from Zona 21
9.0 out of 10, Wonderful, (321)
"Clean room, very helpful staff and very convenient for the airport "
United States
Ashley
The price is ฿1,546
฿1,886 total
includes taxes & fees
7 Jan - 8 Jan 2026
Casa 96
Reception
Hilton Garden Inn Guatemala City

Hilton Garden Inn Guatemala City

4.0 star property
Zona 9, 6.4 km from Zona 21
8.8 out of 10, Excellent, (917)
"Clean and comfortable room, staff always nice."
United States
MARCELA
The price is ฿2,527
฿3,083 total
includes taxes & fees
14 Dec - 15 Dec
Hilton Garden Inn Guatemala City
Outdoor pool
Hyatt Centric Guatemala City

Hyatt Centric Guatemala City

4.5 star property
Zona 10, 6.6 km from Zona 21
9.6 out of 10, Exceptional, (782)
"the hotel is perfectly located. The staff is happy, courteous, helpful. Food is good. Great Breakfast Buffett, good room service. We will return every time we go back to Guatemala City."
United States
Fernando
The price is ฿4,279
฿5,221 total
includes taxes & fees
23 Dec - 24 Dec
Hyatt Centric Guatemala City
Restaurant
Villas Santander - Deluxe Stay

Villas Santander - Deluxe Stay

3.0 star property
Zona 10, 6.7 km from Zona 21
7.6 out of 10, Good, (213)
"The balcony view was a little scenic. Enjoyed how clean the rooms were "
United States
Rosa
The price is ฿1,314
฿1,603 total
includes taxes & fees
10 Dec - 11 Dec
Villas Santander - Deluxe Stay
Terrace/patio
Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa

4.5 star property
19.8 km from Zona 21
9.4 out of 10, Exceptional, (1001)
"Great place to stay. "
United States
tania
The price is ฿4,838
฿5,902 total
includes taxes & fees
10 Dec - 11 Dec
Los Pasos Boutique Hotel & Spa
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas
Hotel Vista Quince

Hotel Vista Quince

5.0 star property
7.5 km from Zona 21
8.6 out of 10, Excellent, (213)
"Fast check in. Nice staff and room. Awesome revolving restaurant."
United States
Randall
The price is ฿4,946
฿6,034 total
includes taxes & fees
12 Dec - 13 Dec
Hotel Vista Quince
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

3.5 star property
20.2 km from Zona 21
9.4 out of 10, Exceptional, (643)
"Always the best nicest friendliest staff and the location is historic a place to fall in love again and again "
United States
Romilio
The price is ฿5,600
฿7,611 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Posada de Don Rodrigo Antigua
Terrace/patio
In & Out Hotel

In & Out Hotel

3.0 star property
Zona 13, 4.4 km from Zona 21
8.6 out of 10, Excellent, (803)
"We needed a place close to the airport for just one night, preferably with transport to the airport included. In & Out was a good fit. It is not a fancy place, but is clean and comfortable and they provide a good breakfast menu."
United States
Cynthia
In & Out Hotel
In-room safe, desk, soundproofing, iron/ironing board
Adriatika Hotel & Residence

Adriatika Hotel & Residence

4.5 star property
Zona 14, 3.8 km from Zona 21
9.4 out of 10, Exceptional, (935)
"Great stay"
United States
Alejandro
The price is ฿3,341
฿4,076 total
includes taxes & fees
3 Jan - 4 Jan 2026
Adriatika Hotel & Residence
Property amenity
Porta Hotel Antigua

Porta Hotel Antigua

4.5 star property
20.1 km from Zona 21
9.4 out of 10, Exceptional, (1001)
"Everything about this hotel was fantastic. The bed was so comfortable. "
United States
Raymond
The price is ฿5,640
฿7,200 total
includes taxes & fees
9 Dec - 10 Dec
Porta Hotel Antigua
Egyptian cotton sheets, premium bedding, in-room safe, desk
El Convento Boutique Hotel

El Convento Boutique Hotel

4.0 star property
19.9 km from Zona 21
9.4 out of 10, Exceptional, (800)
"Great hotel to explore Antigua "
United States
vered
The price is ฿5,185
฿6,805 total
includes taxes & fees
9 Dec - 10 Dec
El Convento Boutique Hotel
Exterior
Naif Boutique Hotel

Naif Boutique Hotel

3.0 star property
20.4 km from Zona 21
9.0 out of 10, Wonderful, (370)
"Well located, friendly staff. Would stay again."
United States
Cristian Paolo
The price is ฿3,883
฿4,737 total
includes taxes & fees
19 Dec - 20 Dec
Naif Boutique Hotel
Exterior
All Suite El Marques de Antigua

All Suite El Marques de Antigua

3.5 star property
20.1 km from Zona 21
9.4 out of 10, Exceptional, (294)
"Great location and very clean"
United States
Saul
All Suite El Marques de Antigua
Front of property
Mestizo Cortijo

Mestizo Cortijo

3.0 star property
22.9 km from Zona 21
9.0 out of 10, Wonderful, (92)
"Nice place to stay and enjoy Antigua Guatemala "
United States
Allan
The price is ฿3,777
฿4,608 total
includes taxes & fees
11 Dec - 12 Dec
Mestizo Cortijo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Zona 21

Find the best Zona 21 areas for the activities you enjoy most.

Zona 10

Zona 10 is known for its abundant dining options, and you can plan a trip to Oakland Mall and Plaza Fontabella Shopping Center while you're in town.

Zona 1

Zona 1 is noteworthy for its historical sites, and you can make a stop at top attractions like Guatemala City Hall and Central Market.

Zona 9

Travellers come to Zona 9 for its abundant dining options, and you can see top attractions like Avenida La Reforma and Torre del Reformador while you're in town.

Zona 13

Zona 13 is noteworthy for its gardens, and you can make a stop at top attractions like Avenida Las Américas and El Obelisco.

Zona 16

Travellers like the festivals in Zona 16, and Paseo Cayala is a top attraction you might want to visit.

Top Zona 21 Hotel Reviews

The Westin Camino Real, Guatemala

The Westin Camino Real, Guatemala

10/10 Excellent
"Very friendly staff, clean room, great restaurants!"
Adam 1-night trip
Posted 3 days ago
The Westin Camino Real, Guatemala

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Zona 21?
Travellers are sure to enjoy a stay in Guatemala City's Zona 21 neighbourhood.
If I need to cancel my hotel reservation in Zona 21, will I receive a refund?
Yes, most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best deals available in Zona 21.
What is there to do around this Guatemala City neighbourhood?
Mundo Petapa, Guatemalan Exporters Association and Parque Las Américas are just a few of the places to visit in and around Zona 21. When you're sightseeing in Guatemala City, Embassy of Peru and Avenida Las Américas are also worth a stop.