Find hotels in Upstate South Carolina, SC from ฿2,135

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Our top choices for Upstate South Carolina hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (708 reviews)
"Clean room comfortable beds"
United States
Cheryl
The price is ฿2,773
฿3,257 total
includes taxes & fees
9 Jun - 10 Jun
Quality Inn Seneca Clemson Area US-123

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
Anderson
9.2 out of 10, Wonderful, (623 reviews)
"Room was clean and customer service was excellent, check in was smooth "
United States
Gina
The price is ฿3,594
฿3,989 total
includes taxes & fees
3 Jul - 4 Jul
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (846 reviews)
"This place is always clean and staff is so kind and helpful"
United States
Osiry
The price is ฿3,709
฿4,117 total
includes taxes & fees
14 Jun - 15 Jun
Hampton Inn Anderson/ Alliance Business Park

Hampton Inn Greer Greenville, SC

Hampton Inn Greer Greenville, SC
2.5 star property
Greer
9.6 out of 10, Exceptional, (462 reviews)
"great service all around."
United States
Alberto
The price is ฿4,541
฿4,950 total
includes taxes & fees
14 Jun - 15 Jun
Hampton Inn Greer Greenville, SC

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (234 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
United States
Sarah
The price is ฿4,240
฿4,663 total
includes taxes & fees
10 Jun - 11 Jun
Fairfield Inn & Suites Seneca Clemson Univ Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,006 reviews)
"Beautiful property and nice room."
United States
Lynzee
The price is ฿3,561
฿4,421 total
includes taxes & fees
15 Jun - 16 Jun
Lakeside Lodge Clemson

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (858 reviews)
"Terrific place to stay and the staff was very helpful too."
United States
Anne
The price is ฿4,868
฿5,404 total
includes taxes & fees
18 Jun - 19 Jun
The Inn at Patrick Square

Days Inn by Wyndham Greenville South/Mauldin

Days Inn by Wyndham Greenville South/Mauldin
2.0 star property
Mauldin
7.6 out of 10, Good, (706 reviews)
"In for George Strait and location was convenient with nice staff and well kept property. "
United States
Scott
The price is ฿2,314
฿2,545 total
includes taxes & fees
7 Jun - 8 Jun
Days Inn by Wyndham Greenville South/Mauldin

Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel
3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (741 reviews)
"Great for visiting my granddaughter at Lander. Was attending graduation this time. I always stay here when in town."
United States
Margaret
The price is ฿3,793
฿4,210 total
includes taxes & fees
14 Jun - 15 Jun
Inn on the Square, an Ascend Collection Hotel

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very good, (1,001 reviews)
"We always stay here when in Clemson. It's convenient and the breakfast and restaurant are great."
United States
Greg
The price is ฿3,122
฿3,465 total
includes taxes & fees
9 Jun - 10 Jun
Best Western Plus Clemson Hotel & Conference Center

Quality Inn Clinton - Laurens I-26

Quality Inn Clinton - Laurens I-26
2.5 star property
Clinton
7.4 out of 10, Good, (554 reviews)
"Clean room, easy parking, we were plenty comfortable."
United States
Christine
The price is ฿2,076
฿2,436 total
includes taxes & fees
3 Jul - 4 Jul
Quality Inn Clinton - Laurens I-26

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
Anderson
8.4 out of 10, Very good, (1,004 reviews)
"Wonderful staff very helpful"
United States
atlantis
The price is ฿2,620
฿2,909 total
includes taxes & fees
5 Jul - 6 Jul
Microtel Inn & Suites by Wyndham Anderson/Clemson

Hampton Inn & Suites Clinton - I-26

Hampton Inn & Suites Clinton - I-26
2.5 star property
Clinton
9.0 out of 10, Wonderful, (742 reviews)
"The breakfast was very good and the set up was excellent. "
United States
Sarah
The price is ฿3,898
฿4,366 total
includes taxes & fees
1 Jul - 2 Jul
Hampton Inn & Suites Clinton - I-26

Deluxe Inn

Deluxe Inn
2.0 star property
Mauldin
9.4 out of 10, Exceptional, (3 reviews)
The price is ฿2,058
฿2,264 total
includes taxes & fees
11 Jun - 12 Jun
Deluxe Inn

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.8 out of 10, Excellent, (497 reviews)
"Room very clean staff was great breakfast was really good with lots of options "
United States
melvin
The price is ฿2,853
฿3,110 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express Gaffney by IHG

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1,246 reviews)
"Nice hotel, clean and breakfast was awesome!"
United States
James
The price is ฿4,073
฿4,481 total
includes taxes & fees
14 Jun - 15 Jun
Embassy Suites Greenville Golf Resort & Conference Center

Courtyard by Marriott Greenville Mauldin

Courtyard by Marriott Greenville Mauldin
3.0 star property
Greenville
9.2 out of 10, Wonderful, (351 reviews)
"Very clean, Close to activities we needed to do, very accommodating"
United States
Chavaun
The price is ฿3,888
฿4,277 total
includes taxes & fees
14 Jun - 15 Jun
Courtyard by Marriott Greenville Mauldin

Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
3.0 star property
Spartanburg
8.4 out of 10, Very good, (916 reviews)
"Nice property"
United States
Dusty
The price is ฿2,729
฿3,029 total
includes taxes & fees
17 Jun - 18 Jun
Best Western Spartanburg Northwest

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (810 reviews)
"Amazing hotel in the heart of Clemson!"
United States
Georgia
The price is ฿4,969
฿5,516 total
includes taxes & fees
9 Jun - 10 Jun
The Shepherd Hotel Downtown Clemson

Best Western Plus Spartanburg

Best Western Plus Spartanburg
2.5 star property
Spartanburg
8.4 out of 10, Very good, (1,003 reviews)
"Wonderful staff, clean room and convenient parking."
United States
Paul
The price is ฿2,849
฿3,226 total
includes taxes & fees
28 Jun - 29 Jun
Best Western Plus Spartanburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

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Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

More cheap stays in Upstate South Carolina