Find hotels in Upstate South Carolina, SC from ฿2,120

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Our top choices for Upstate South Carolina hotels

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
10.0 out of 10, Exceptional, (2 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
United States
Katlynn
The price is ฿3,104
฿6,055 total
includes taxes & fees
15 Mar - 16 Mar
Carolina Camp Cedar

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very good, (683 reviews)
"Everting was good"
United States
Susan
The price is ฿2,441
฿2,876 total
includes taxes & fees
13 Mar - 14 Mar
Quality Inn Seneca Clemson Area US-123

Holiday Inn Express Gaffney by IHG

Holiday Inn Express Gaffney by IHG
2.5 star property
Gaffney
8.8 out of 10, Excellent, (450 reviews)
"Great people n place"
United States
Janice
The price is ฿2,686
฿2,927 total
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express Gaffney by IHG

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
2.5 star property
Clemson
8.2 out of 10, Very good, (1,009 reviews)
"Our room was very clean and the staff were very nice and courteous!"
United States
Tina
The price is ฿2,859
฿3,173 total
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Clemson Hotel & Conference Center

Inn on the Square, an Ascend Collection Hotel

Inn on the Square, an Ascend Collection Hotel
3.0 star property
Uptown Greenwood
9.2 out of 10, Wonderful, (722 reviews)
"The staff were all very pleasant. "
United States
michelle
The price is ฿3,414
฿3,789 total
includes taxes & fees
29 Mar - 30 Mar
Inn on the Square, an Ascend Collection Hotel

Inn @ Clemson

Inn @ Clemson
2.5 star property
Clemson
8.2 out of 10, Very good, (1,006 reviews)
"Staff and hotel was amazing "
United States
Keren
The price is ฿3,602
฿3,998 total
includes taxes & fees
19 Mar - 20 Mar
Inn @ Clemson

Hampton Inn Easley

Hampton Inn Easley
2.5 star property
Easley
9.2 out of 10, Wonderful, (691 reviews)
"Friendly staff, very comfortable room, excellent hot breakfast."
United States
Thomas
The price is ฿4,120
฿4,573 total
includes taxes & fees
12 Mar - 13 Mar
Hampton Inn Easley

Comfort Inn & Suites Greer - Greenville

Comfort Inn & Suites Greer - Greenville
2.5 star property
Greer
8.6 out of 10, Excellent, (764 reviews)
"this is the best hotel friendly clean rooms, quiet and the staff is great."
United States
pamela
The price is ฿2,662
฿2,981 total
includes taxes & fees
15 Mar - 16 Mar
Comfort Inn & Suites Greer - Greenville

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,002 reviews)
"Great place and location, great mattress, "
United States
Jeffrey
The price is ฿3,417
฿4,242 total
includes taxes & fees
8 Mar - 9 Mar
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (814 reviews)
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is ฿3,676
฿4,044 total
includes taxes & fees
16 Mar - 17 Mar
Tru by Hilton Seneca Clemson

The Inn at Patrick Square

The Inn at Patrick Square
3.5 star property
Clemson
9.8 out of 10, Exceptional, (801 reviews)
"Clean room, great location, wonderful staff!"
United States
Joyce
The price is ฿4,671
฿5,185 total
includes taxes & fees
8 Mar - 9 Mar
The Inn at Patrick Square

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (665 reviews)
"The hotel was clean staff was amazing room was outstanding."
United States
Clifford
The price is ฿4,746
฿6,279 total
includes taxes & fees
8 Mar - 9 Mar
Hotel Hartness

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
Anderson
9.0 out of 10, Wonderful, (598 reviews)
"Clean, quiet, comfortable stay- staff is always friendly and helpful!"
United States
Lori
The price is ฿3,449
฿3,828 total
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Aloft Greenville Downtown

Aloft Greenville Downtown
3.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1,003 reviews)
"Room was very clean, the staff was great and the location was perfect!"
United States
Mike
The price is ฿4,104
฿4,514 total
includes taxes & fees
15 Mar - 16 Mar
Aloft Greenville Downtown

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
2.5 star property
Clemson
8.2 out of 10, Very good, (1,001 reviews)
"Room was extremely clean, continental breakfast was amazing with many options, and staff were very friendly. Great hotel! "
United States
Delaney
The price is ฿3,196
฿3,548 total
includes taxes & fees
11 Mar - 12 Mar
Comfort Inn & Suites Clemson - University Area

Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
3.0 star property
Spartanburg
8.2 out of 10, Very good, (845 reviews)
"Very Clean, Friendly Staff"
United States
Edward
The price is ฿2,608
฿2,895 total
includes taxes & fees
1 Apr - 2 Apr
Best Western Spartanburg Northwest

Spartanburg Marriott

Spartanburg Marriott
3.5 star property
Spartanburg
8.6 out of 10, Excellent, (1,001 reviews)
"great hotel! Clean and awesome restaurant!"
United States
Alicia
The price is ฿3,699
฿4,106 total
includes taxes & fees
15 Mar - 16 Mar
Spartanburg Marriott

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
2.5 star property
Greenville
9.2 out of 10, Wonderful, (1,448 reviews)
"The room was clean, staff was wonderful, quiet and convenient location. "
United States
Tammy
The price is ฿2,608
฿2,869 total
includes taxes & fees
15 Mar - 16 Mar
Best Western Plus Greenville I-385 Inn & Suites

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (651 reviews)
"The stay was amazing "
United States
Tabatha
The price is ฿3,062
฿3,368 total
includes taxes & fees
12 Mar - 13 Mar
Best Western Seneca-Clemson

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
3.5 star property
Greenville
9.0 out of 10, Wonderful, (1,096 reviews)
"Great staff, awesome property"
United States
Annisha
The price is ฿3,640
฿4,004 total
includes taxes & fees
15 Mar - 16 Mar
Embassy Suites Greenville Golf Resort & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Upstate South Carolina

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Stay near popular Southeastern United States attractions

Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

It is only a 1 mile hike to this beauty.  View a video about it here:  https://www.hdcarolina.com/episode/riley-moore-falls

#Waterfall
Photo by Ryan Watts
Open Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

More cheap stays in Upstate South Carolina