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Find hotels in Upstate South Carolina, SC from ฿2,135
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Go beyond your typical stay in Upstate South Carolina
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Our top choices for Upstate South Carolina hotels

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123Downtown
8.0 out of 10, Very good, (708 reviews)
The price is ฿2,773
฿3,257 total
includes taxes & fees
9 Jun - 10 Jun

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (623 reviews)
The price is ฿3,594
฿3,989 total
includes taxes & fees
3 Jul - 4 Jul

Hampton Inn Anderson/ Alliance Business Park
Hampton Inn Anderson/ Alliance Business ParkAnderson
9.2 out of 10, Wonderful, (846 reviews)
The price is ฿3,709
฿4,117 total
includes taxes & fees
14 Jun - 15 Jun

Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (462 reviews)
The price is ฿4,541
฿4,950 total
includes taxes & fees
14 Jun - 15 Jun

Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (234 reviews)
The price is ฿4,240
฿4,663 total
includes taxes & fees
10 Jun - 11 Jun

Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,006 reviews)
The price is ฿3,561
฿4,421 total
includes taxes & fees
15 Jun - 16 Jun

The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (858 reviews)
The price is ฿4,868
฿5,404 total
includes taxes & fees
18 Jun - 19 Jun

Days Inn by Wyndham Greenville South/Mauldin
Days Inn by Wyndham Greenville South/MauldinMauldin
7.6 out of 10, Good, (706 reviews)
The price is ฿2,314
฿2,545 total
includes taxes & fees
7 Jun - 8 Jun

Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (741 reviews)
The price is ฿3,793
฿4,210 total
includes taxes & fees
14 Jun - 15 Jun

Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference CenterClemson
8.2 out of 10, Very good, (1,001 reviews)
The price is ฿3,122
฿3,465 total
includes taxes & fees
9 Jun - 10 Jun

Quality Inn Clinton - Laurens I-26
Quality Inn Clinton - Laurens I-26Clinton
7.4 out of 10, Good, (554 reviews)
The price is ฿2,076
฿2,436 total
includes taxes & fees
3 Jul - 4 Jul

Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/ClemsonAnderson
8.4 out of 10, Very good, (1,004 reviews)
The price is ฿2,620
฿2,909 total
includes taxes & fees
5 Jul - 6 Jul

Hampton Inn & Suites Clinton - I-26
Hampton Inn & Suites Clinton - I-26Clinton
9.0 out of 10, Wonderful, (742 reviews)
The price is ฿3,898
฿4,366 total
includes taxes & fees
1 Jul - 2 Jul

Deluxe Inn
Deluxe InnMauldin
9.4 out of 10, Exceptional, (3 reviews)
The price is ฿2,058
฿2,264 total
includes taxes & fees
11 Jun - 12 Jun

Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (497 reviews)
The price is ฿2,853
฿3,110 total
includes taxes & fees
14 Jun - 15 Jun

Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,246 reviews)
The price is ฿4,073
฿4,481 total
includes taxes & fees
14 Jun - 15 Jun

Courtyard by Marriott Greenville Mauldin
Courtyard by Marriott Greenville MauldinGreenville
9.2 out of 10, Wonderful, (351 reviews)
The price is ฿3,888
฿4,277 total
includes taxes & fees
14 Jun - 15 Jun

Best Western Spartanburg Northwest
Best Western Spartanburg NorthwestSpartanburg
8.4 out of 10, Very good, (916 reviews)
The price is ฿2,729
฿3,029 total
includes taxes & fees
17 Jun - 18 Jun

The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown ClemsonClemson
9.8 out of 10, Exceptional, (810 reviews)
The price is ฿4,969
฿5,516 total
includes taxes & fees
9 Jun - 10 Jun

Best Western Plus Spartanburg
Best Western Plus SpartanburgSpartanburg
8.4 out of 10, Very good, (1,003 reviews)
The price is ฿2,849
฿3,226 total
includes taxes & fees
28 Jun - 29 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park.

Photo by Ryan Watts
Open Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews

Drury Inn & Suites Greenville
10/10 Excellent
More cheap stays in Upstate South Carolina

Sleep Inn Spartanburg Southwest
501 South Blackstock Rd Spartanburg SC
The price is ฿1,923 per night from 6 Jul to 7 Jul
฿1,923
฿2,135 total
6 Jul - 7 Jul
includes taxes & fees
6/10 (611 reviews)













































































