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Check availability on Syracuse Luxury Hotels

Our top choices for Syracuse luxury hotels

Sports facility
Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia

5.0 star property
Syracuse
9.6 out of 10, Exceptional, (94)
"This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!"
United States
Jeffrey
The price is ฿12,437
฿14,052 total
includes taxes & fees
12 Dec - 13 Dec
Wellness & Spa Hotel Principe di Fitalia
Classic Double Room, Partial Sea View | View from room
Charme Hotel Henry's House

Charme Hotel Henry's House

4.0 star property
Ortigia
9.6 out of 10, Exceptional, (322)
"Great location. Very friendly and helpful staff. Nice breakfast."
United States
Alan
The price is ฿8,961
฿10,229 total
includes taxes & fees
27 Dec - 28 Dec
Charme Hotel Henry's House
Exterior
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

5.0 star property
Ortigia
9.4 out of 10, Exceptional, (250)
"Great location and very friendly staff"
United States
James
The price is ฿6,997
฿8,068 total
includes taxes & fees
6 Jan - 7 Jan 2026
Ortea Palace Hotel, Sicily, Autograph Collection
Exterior
Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa

5.0 star property
Syracuse
9.2 out of 10, Wonderful, (209)
"We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. "
United Kingdom
David
Dimora Caiammari Luxury Hotel & Spa
Reception
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

4.0 star property
Ortigia
9.4 out of 10, Exceptional, (659)
"Great hotel"
United States
Caterina
The price is ฿6,135
฿7,120 total
includes taxes & fees
19 Dec - 20 Dec
Palazzo Artemide - VRetreats, SLH Collection
Aerial view
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

5.0 star property
Ortigia
9.0 out of 10, Wonderful, (570)
"Great stay!"
United States
Liza
The price is ฿6,291
฿7,292 total
includes taxes & fees
7 Jan - 8 Jan 2026
Grand Hotel Ortigia Siracusa
Front of property – evening/night
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

4.0 star property
Ortigia
9.6 out of 10, Exceptional, (905)
"The breakfast was delicious, the staff impeccable and the room delightful. All in all an excellent stay which I would wholeheartedly recommend. "
United Kingdom
Sarah
Algila' Ortigia Charme Hotel
Pool
UNA HOTELS One Siracusa

UNA HOTELS One Siracusa

4.0 star property
Grottasanta
8.6 out of 10, Excellent, (540)
"Very nice hotel, nice sized rooms, great staff that was very helpful."
United States
Mark
The price is ฿4,356
฿4,966 total
includes taxes & fees
11 Dec - 12 Dec
UNA HOTELS One Siracusa
Terrace/patio
Caportigia Boutique Hotel

Caportigia Boutique Hotel

5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (256)
"Fine quality hotel with exceptional service. "
United States
Peter
The price is ฿4,205
฿4,995 total
includes taxes & fees
19 Dec - 20 Dec
Caportigia Boutique Hotel
Seasonal outdoor pool
Grand Hotel Villa Politi

Grand Hotel Villa Politi

4.0 star property
Grottasanta
8.6 out of 10, Excellent, (941)
"Wonderful hotel, nice area and great buffet breakfast"
United States
paula
The price is ฿3,484
฿3,971 total
includes taxes & fees
18 Dec - 19 Dec
Grand Hotel Villa Politi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Syracuse Hotel Reviews

Grand Hotel Villa Politi

Grand Hotel Villa Politi

10/10 Excellent
"Great old “grand hotel”. Beautiful property. "
Steven 1-night trip
Posted 1 month ago
Grand Hotel Villa Politi

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Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Syracuse?
Travel to Catania (CTA-Fontanarossa) Airport or Comiso (CIY-Vincenzo Magliocco) Airport, and then treat yourself to a stay at one of 5 Syracuse luxury hotels. While you're visiting, you might want to think about enjoying the ruins and sightseeing, which Syracuse is known for.
What's the best luxury place to stay in Syracuse?
Grand Hotel Des Ètrangers - The Leading Hotels of the World is a luxury hotel with a full-service spa and a seasonal outdoor pool, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Grand Hotel Ortigia Siracusa and Dimora Caiammari Luxury Hotel & Spa are other upscale choices for your trip.
How many luxury hotels will I be able to find in Syracuse?
Lie in the lap of luxury during your getaway to Syracuse in one of Expedia's 5 luxury hotels.
When can I expect good weather in Syracuse?
Planning for the weather is a good way to make your trip to Syracuse relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are February and January, with an average of 14°C. Average annual precipitation for Syracuse is 653 mm.
What's there to see and do in Syracuse?
Experience all that Syracuse has to offer when you visit Temple of Apollo, Lungomare di Ortigia and Piazza del Duomo. If you have a little extra time during your trip, you might want to check out Cathedral of Syracuse and Porto Piccolo.
How can I get around Syracuse?
It's easier to get around town in style when you know your options. To venture out into the surrounding area, ride one of the trains from Syracuse Station or Targia Station.