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Holiday Inn Express & Suites St. Louis South - I-55 by IHG

2.5 star property
Travelers can start their day with a complimentary breakfast buffet before heading to the 24-hour fitness center for a morning workout session

Choose dates to view prices

Located in the business district, Holiday Inn Express & Suites St. Louis South - I-55 offers practical comforts for busy travelers. Enjoy a hearty breakfast buffet, reliable in-room WiFi, an indoor pool for relaxation, and a 24-hour gym.

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • Parking included
  • Free Wi-Fi
  • Air-conditioning

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

9.4 out of 10
Exceptional
(13 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

9.6 out of 10
Exceptional
(4 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Suite, 1 Bedroom (2 Queen, Extra Living Area)

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Suite, 1 Bedroom (2 Queen, Extra Living Area)

9.6 out of 10
Exceptional
(32 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

9.0 out of 10
Wonderful
(7 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed
  • Free Wi-Fi

Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

10.0 out of 10
Exceptional
(2 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (Extra Living, Walk in Shwr)

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Suite, 1 King Bed (Extra Living, Walk in Shwr)

9.2 out of 10
Wonderful
(5 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed
  • Free Wi-Fi

View all photos for Standard Room, 1 King Bed (Bath Shwr Combo)

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Standard Room, 1 King Bed (Bath Shwr Combo)

9.6 out of 10
Exceptional
(18 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed
  • Free Wi-Fi

Standard Room

  • 28 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Single Bed
  • Free Wi-Fi

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed
  • Free Wi-Fi

View all photos for Standard Room, 2 Queen Beds

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Standard Room, 2 Queen Beds

9.6 out of 10
Exceptional
(79 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

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  • Breakfast included
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About the area

Located in St. Louis, Holiday Inn Express & Suites St. Louis South - I-55 by IHG is in the business district. Arnold Historical Society & Museum and Jefferson Barracks Historic Park are cultural highlights, and some of the area's landmarks include Missouri Civil War Museum and Ulysses S. Grant National Historic Site. Ready for a night out? Consider Das Bevo and Off Broadway. Visit our St. Louis travel guide
Map
4250 Midamerica Lane, St. Louis, MO, 63129

What's nearby

  • A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.
    Busch Stadium
    16 min drive - 27.9 km
  • The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.
    Gateway Arch
    17 min drive - 28.6 km
  • A historic building with a clock tower and red-roofed structures.
    St. Louis Union Station
    18 min drive - 27.9 km
  • A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.
    Forest Park
    20 min drive - 32.4 km
  • A bronze elephant sculpture with a pumpkin on its back, surrounded by greenery.
    St. Louis Zoo
    23 min drive - 35.7 km

Getting around

  • Kirkwood Station
    17 min drive
  • Lambert-St. Louis International Airport (STL)
    32 min drive

Restaurants

  • Burger King
    11 min walk
  • Popeyes Louisiana Kitchen
    4 min walk
  • Hardee's / Red Burrito
    11 min walk
  • Rich & Charlie's Italian Restaurant
    3 min drive
  • Taco Bell
    11 min walk

About this property

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

  • Hotel in the business district
  • A free breakfast buffet, a 24-hour gym and a business centre are just a few of the amenities provided at Holiday Inn Express & Suites St. Louis South - I-55 by IHG. Stay connected with free in-room WiFi.
  • You'll also enjoy perks such as:
    • An indoor pool, along with sunloungers
    • Free self-parking
    • Meeting rooms, a banquet hall and a 24-hour front desk
    • A lift, smoke-free property and a front desk safe
    • Guest reviews say great things about the breakfast and helpful staff
  • Room features
  • All 99 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as thoughtful touches such as free WiFi and safes. Guest reviews highly rate the cleanliness rooms at the property.
  • Extra amenities include:
    • Bathrooms with free toiletries and hairdryers
    • 49-inch flat-screen TVs with cable channels
    • Wardrobes/cupboards, fridges and microwaves

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi

Parking and transport

  • Free self parking on site
  • Limited on-site self parking
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available daily 6:00 AM to 9:30 AM

Things to do

  • 24-hour gym
  • Indoor pool

Family friendly

  • In-room cot
  • In-room microwave
  • In-room refrigerator
  • Indoor pool

Conveniences

  • 24-hour front desk
  • Safe at front desk
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Lift
  • Stair-free path to entrance
  • Visual alarms in hallways
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to lift
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible van parking

More

  • 4 floors
  • Banquet hall
  • No plastic drinking straws
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes
  • Free cot

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 49-inch flat-screen TV with cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Refrigerator

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe

Policies

Check-in

Check-in start time: 3:00 PM; check-in end time: 2:30 AM
Minimum check-in age - 21

Check-out

Check-out before 11 AM
Contactless check-out

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed (service animals are welcome, and are exempt from fees)

Children and extra beds

Children are welcome
Free cots are available on request at the property

Payment types at the property

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

We should mention

Pool access available from 8 AM to 10 PM
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG have a pool?

Yes, this property has an indoor pool. Pool access is from 8 AM to 10 PM.

Is Holiday Inn Express & Suites St. Louis South - I-55 by IHG pet-friendly?

No, only service animals are welcome at the property.

How much is parking at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Self-parking is free at this property.

What time is check-in at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Check-in start time: 3:00 PM; check-in end time: 2:30 AM.

What time is check-out at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Checkout is at 11 AM.

Where is Holiday Inn Express & Suites St. Louis South - I-55 by IHG located?

Situated in the business district, this hotel is 0.3 mi (0.6 km) from Barnes Jewish South Campus and within 3 miles (5 km) of St Anthony's and Suson Park. Meramec River and Mercy Hospital South are also within 6 miles (10 km).

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Holiday Inn Express & Suites St. Louis South - I-55 by IHG Reviews

9.6

Exceptional

9.6

Cleanliness

9.6

Location

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 802 out of 1001 reviews
Rating 8 - Good. 141 out of 1001 reviews
Rating 6 - Okay. 36 out of 1001 reviews
Rating 4 - Poor. 15 out of 1001 reviews
Rating 2 - Terrible. 7 out of 1001 reviews

Reviews

Verified

10/10 Excellent

David

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice stay with polite and helpful staff.
Stayed 4 nights in May 2026
Verified

10/10 Excellent

Debra

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great facility with very friendly and accommodating staff!
Stayed 4 nights in May 2026
Verified

10/10 Excellent

Walter

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This was one of our favorite hotels we have ever stayed at. We really don’t have any complaints. Everything was clean and everyone was nice. Breakfast was good. Coffee was excellent.
Stayed 3 nights in May 2026
Verified

10/10 Excellent

Jamie

Liked: Cleanliness, staff & service
Clean room, friendly staff.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

ARIANNE

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Brand new hotel great beds and quiet despite it being sold out the night we stayed.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Megan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great breakfast, location was ideal for activities in St Louis, complimentary parking and warm cookies at night!
Stayed 4 nights in Mar 2026
Verified

10/10 Excellent

George

Liked: Cleanliness, staff & service, amenities
Clean rooms, great friendly staff, very good breakfast with lots to choose from
Stayed 1 night in Jan 2026
Verified

6/10 Okay

Barbara

Beds were terrible. Worn out and lumpy. Staff was nice. Breakfast was varied enough for everyone’s taste.
Stayed 1 night in May 2026
Verified

10/10 Excellent

HEATHER

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The place was clean, the pool was functional, the food was decent, and my kids favorite part was the cookie hour! Will definitely pick this hotel when we come back to the St Louis area!
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Mary C

Liked: Cleanliness, staff & service, property conditions & facilities
Breakfast was great, quite a variety of food and drink. Staff were all kind and thoughtful. Real treat was warm cookies and milk in evening!!
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was so kind and helpful. Breakfast was delicious. We really loved the fluffy scrambled eggsa and the bean to brew coffee machine. Will definitely stay again.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Mary

Liked: Cleanliness, staff & service, amenities
The room is clean, the bed and pillows are super comfy and the breakfast is great! I travel to the area a few times a year for work and this is my new favorite place to stay.
Stayed 4 nights in Feb 2026
Verified

10/10 Excellent

Janice

Liked: Cleanliness, staff & service, amenities
Enjoyed the cleanliness and comfort of the bed and room and the friendly staffand the freshly roasted coffeecofrrroascoffee
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

James

Clean room, location, excellent staff
Stayed 4 nights in Dec 2025
Verified

10/10 Excellent

Anita

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and staff was friendly.
Stayed 2 nights in Nov 2025
Verified

10/10 Excellent

Jessica

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The breakfast was fresh, hot, and delicious. Various choices from cinnamon rolls and pancakes to cheese omelettes and sausage to cereal and yogurt. The room was clean.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Terri

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Lovely clean comfortable hotel. The only improvement would if streaming on TV was possible. But overall an excellent hotel
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

James

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean and nice.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Pamela

Liked: Cleanliness, amenities, property conditions & facilities
Staff is very nice! The rooms are clean and comfortable.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Brandy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Friendly staff clean rooms
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Ashley

Liked: Cleanliness, staff & service, amenities
Room was clean. Area was quiet. Cookie hour was nice and the breakfast had lots of options.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Jessica

Great breakfast, great rooms and comfy beds.
Stayed 1 night in May 2025
Verified

10/10 Excellent

Roderick

Liked: Cleanliness, amenities, property conditions & facilities
A clean room and a nice room, with a nice bathroom, comfortable bed, tv with a good selection of channels free, the warm chocolate chip cookies with milk at 8 pm was very nice complimentary, and complimentary breakfast was very good! Staff was very friendly and helpful! Nice swimming pool
Stayed 1 night in Jan 2026
Verified

8/10 Good

Therese

Liked: Cleanliness, staff & service, amenities
Clean rooms. Easy check-in. Great breakfast.
Stayed 4 nights in Dec 2025
Verified

8/10 Good

Eleanor

Liked: Cleanliness, staff & service, amenities
Everything was clean. Coffee was great. Breakfast was better than expected. We will be staying at this hotel our next trip to St. Louis.
Stayed 2 nights in Jan 2026

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