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Check prices for these dates

Tonight
11 Dec - 12 Dec
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12 Dec - 13 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Santo Domingo hotels

Breakfast, lunch, dinner served; Mexican cuisine
Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City
4.0 star property
Historic Center, 12.2 km from Santo Domingo
9.8 out of 10, Exceptional, (2637)
"Always a great stay. Great staff, food and comfortable room."
Canada
John
The price is ฿5,281
฿6,311 total
includes taxes & fees
14 Dec - 15 Dec
Zocalo Central & Rooftop Mexico City
Breakfast, lunch, dinner served; Mexican cuisine
Hotel Catedral

Hotel Catedral

Hotel Catedral
4.0 star property
Historic Center, 12.4 km from Santo Domingo
9.4 out of 10, Exceptional, (2595)
"The room was very clean and the location was great"
United States
Michele
Hotel Catedral
Lobby
Hotel Bellas Artes

Hotel Bellas Artes

Hotel Bellas Artes
4.0 star property
Historic Center, 12.1 km from Santo Domingo
9.8 out of 10, Exceptional, (547)
"Very nice staff, the location is perfect, amenities definitely will consider to stay in the future "
United States
Nelson
The price is ฿2,598
฿3,105 total
includes taxes & fees
14 Dec - 15 Dec
Hotel Bellas Artes
Indoor pool, outdoor pool
Hilton Mexico City Reforma

Hilton Mexico City Reforma

Hilton Mexico City Reforma
4.5 star property
Reforma, 12 km from Santo Domingo
9.4 out of 10, Exceptional, (1052)
"great place . friendly staff and everything was to perfection."
United States
Adriana
The price is ฿5,613
฿6,708 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hilton Mexico City Reforma
2 bars/lounges
Hotel Parque Satelite

Hotel Parque Satelite

Hotel Parque Satelite
3.0 star property
22.4 km from Santo Domingo
9.2 out of 10, Wonderful, (1003)
"Good place to stay nice and clean"
United States
guillermo
The price is ฿1,560
฿1,873 total
includes taxes & fees
15 Dec - 16 Dec
Hotel Parque Satelite
Standard Room, 2 Double Beds, Non Smoking | Pillow-top beds, in-room safe, desk, laptop workspace
Sleep Inn Ciudad de México

Sleep Inn Ciudad de México

Sleep Inn Ciudad de México
3.0 star property
12.3 km from Santo Domingo
8.4 out of 10, Very good, (1000)
"Nice hotel. "
United States
Alejandra
The price is ฿2,207
฿2,637 total
includes taxes & fees
14 Dec - 15 Dec
Sleep Inn Ciudad de México
Interior
Hotel Juarez

Hotel Juarez

Hotel Juarez
2.5 star property
Historic Center, 12.2 km from Santo Domingo
9.0 out of 10, Wonderful, (1782)
"Excelente hotel"
Mexico
César augusto
The price is ฿922
฿1,101 total
includes taxes & fees
17 Dec - 18 Dec
Hotel Juarez
Front of property
Historico Central Hotel

Historico Central Hotel

Historico Central Hotel
4.0 star property
Historic Center, 12 km from Santo Domingo
9.8 out of 10, Exceptional, (2396)
"Location was great and hotel was clean and comfortable "
United States
Daniela
The price is ฿4,578
฿5,470 total
includes taxes & fees
18 Dec - 19 Dec
Historico Central Hotel
Reception
Royal Pedregal Hotel

Royal Pedregal Hotel

Royal Pedregal Hotel
4.0 star property
Tlalpan, 4.6 km from Santo Domingo
9.0 out of 10, Wonderful, (1828)
"Excellent option if you need to be in the southern part of CDMX"
United States
Carlos
The price is ฿2,889
฿3,453 total
includes taxes & fees
31 Dec - 1 Jan 2026
Royal Pedregal Hotel
View from room
Hotel Punto MX

Hotel Punto MX

Hotel Punto MX
3.5 star property
Historic Center, 11.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1424)
"Excellent staff and gorgeous hotel "
United States
Fernando
The price is ฿1,885
฿2,253 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Punto MX
Deluxe Double Room | In-room safe, blackout curtains, soundproofing, iron/ironing board
Punta Alameda

Punta Alameda

Punta Alameda
2.0 star property
Downtown Mexico City, 11.6 km from Santo Domingo
9.4 out of 10, Exceptional, (205)
"Regular cleaning, friendly staff"
Canada
Mukul
Punta Alameda
Deluxe Studio Suite | Minibar, desk, laptop workspace, iron/ironing board
Colmena Hotel CDMX Centro

Colmena Hotel CDMX Centro

Colmena Hotel CDMX Centro
3.0 star property
Historic Center, 12.5 km from Santo Domingo
8.6 out of 10, Excellent, (288)
"I enjoyed my stay. Nice food and location "
United States
Mike
The price is ฿2,019
฿2,413 total
includes taxes & fees
7 Jan - 8 Jan 2026
Colmena Hotel CDMX Centro
Exterior
Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico
3.0 star property
Historic Center, 11.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1079)
"Great location and customer services "
Canada
Hernan
The price is ฿2,362
฿2,823 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hampton Inn & Suites Mexico City - Centro Historico
Reception
Hotel & Villas Panamá

Hotel & Villas Panamá

Hotel & Villas Panamá
3.0 star property
15.1 km from Santo Domingo
8.6 out of 10, Excellent, (937)
"As in the last 14 or more visits throughout the last 11 years I am very happy with my visit and highly recommend villas Panama. safe, clean, great location, very well kept, flexible and warm staff Thank you to the staff and management. "
United States
Jose
Hotel & Villas Panamá
Standard Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout curtains
Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG
3.0 star property
14.7 km from Santo Domingo
9.2 out of 10, Wonderful, (1040)
"Excellent stay!"
United States
Derek
The price is ฿2,103
฿2,513 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Mexico Basilica by IHG
Terrace/patio
Hotel Brasilia

Hotel Brasilia

Hotel Brasilia
3.0 star property
16.5 km from Santo Domingo
9.0 out of 10, Wonderful, (1007)
"Super clean hotel and the staff very pleasant and friendly."
United States
Emanuel
The price is ฿1,902
฿2,273 total
includes taxes & fees
16 Dec - 17 Dec
Hotel Brasilia
Sun deck
Galeria Plaza San Jeronimo

Galeria Plaza San Jeronimo

Galeria Plaza San Jeronimo
4.0 star property
5.1 km from Santo Domingo
9.2 out of 10, Wonderful, (1000)
"Very peaceful and staff was great "
United States
Magiver
The price is ฿3,385
฿4,045 total
includes taxes & fees
26 Dec - 27 Dec
Galeria Plaza San Jeronimo
Exterior
Hotel Plaza Revolución

Hotel Plaza Revolución

Hotel Plaza Revolución
3.5 star property
12.1 km from Santo Domingo
8.8 out of 10, Excellent, (1001)
"A very walkable distance to the Historic Center"
United States
RAUL E
Hotel Plaza Revolución
Free daily buffet breakfast
Hotel MX zocalo CDMX, Trademark Collection by Wyndham

Hotel MX zocalo CDMX, Trademark Collection by Wyndham

Hotel MX zocalo CDMX, Trademark Collection by Wyndham
3.5 star property
Historic Center, 12.1 km from Santo Domingo
8.4 out of 10, Very good, (654)
"Clean room excellent staff and nearby everywhere "
United States
PATRICIA
The price is ฿1,602
฿1,914 total
includes taxes & fees
22 Dec - 23 Dec
Hotel MX zocalo CDMX, Trademark Collection by Wyndham
Terrace/patio
Fiesta Inn Insurgentes Sur

Fiesta Inn Insurgentes Sur

Fiesta Inn Insurgentes Sur
3.5 star property
4.4 km from Santo Domingo
9.2 out of 10, Wonderful, (1000)
"Excellent hotel. "
United States
Annie
The price is ฿3,453
฿4,127 total
includes taxes & fees
2 Jan - 3 Jan 2026
Fiesta Inn Insurgentes Sur
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santo Domingo

Find the best Santo Domingo areas for the activities you enjoy most.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

Polanco which includes heritage architecture, a church or cathedral and a park

Polanco

Visit the most diverse section of Mexico City for sophisticated shopping, dining, accommodations and sightseeing.

La Condesa featuring café scenes

La Condesa

Enjoy 20th-century history in these two sections of Mexico City, with interesting art and architecture reflecting European influences.

Metropolitan Cathedral which includes a church or cathedral, heritage elements and heritage architecture

Historic Center

Consider a visit to Palacio de Bellas Artes and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

Reforma which includes a city, night scenes and central business district

Reforma

Consider a visit to Paseo de la Reforma and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

Top Santo Domingo Hotel Reviews

Hotel Bellas Artes

Hotel Bellas Artes

10/10 Excellent
"The outer facade is misleading because the interior is very nice. Super clean, very courteous staff, walking distance to everything! "
Gabriel 1-night trip
Posted 22 hours ago
Hotel Bellas Artes

Explore a world of travel with Expedia

Frequently asked questions

What is Santo Domingo like?
Travellers to Mexico City's Santo Domingo neighbourhood will be sure to enjoy a stay here.
How many hotels will I find in the Santo Domingo area?
Book one of Expedia's 5 hotels and other accommodation options in Santo Domingo and start exploring everything Mexico City has to offer.
If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?
Yes, most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals available in Santo Domingo.
What are the top things to see and do in Santo Domingo?
Parroquia de San Juan Bautista, Casa del Teatro and Museo Diego Rivera Anahuacalli are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Museo de la Ciudad and Hidalgo Plaza are a couple of additional sights to visit in Mexico City.