Find hotels in Santee, SC from ฿1,926

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Check prices for these dates

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Santee hotels

Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1421)
"Very friendly staff. "
United States
Ramil
The price is ฿2,512
฿2,789 total
includes taxes & fees
23 Dec - 24 Dec
Baymont by Wyndham Santee
Lobby
Tru By Hilton Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (648)
"Nice place to stay"
Canada
Tanya
The price is ฿3,298
฿3,661 total
includes taxes & fees
4 Jan - 5 Jan 2026
Tru By Hilton Santee
Lobby
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1002)
"Staff was pleasant and helpful with restaurant information, room clean. "
United States
Mark
The price is ฿3,310
฿3,675 total
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Inn & Suites Santee
Exterior
Best Western Plus Santee Inn

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1002)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is ฿3,711
฿4,119 total
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Santee Inn
Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1003)
"Staff very friendly, room super clean"
United States
Karine
The price is ฿3,800
฿4,218 total
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Santee
Seasonal outdoor pool
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1005)
"Rooms are clean, friendly staff and easy to get off and back on the highway. "
United States
Michelle
The price is ฿4,219
฿4,683 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hampton Inn Santee-I-95
Exterior
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (975)
"Was able to walk to convenience store and other dinning alternatives. Safe secure building"
United States
Joan
The price is ฿3,392
฿3,765 total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Santee by IHG
Exterior
Econo Lodge Santee

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (309)
"Last minute arrangements stay was quiet and peaceful "
United States
Iasia
The price is ฿1,986
฿2,205 total
includes taxes & fees
7 Jan - 8 Jan 2026
Econo Lodge Santee
Business centre
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (455)
"exellent service"
United States
Mirjana
The price is ฿1,709
฿2,071 total
includes taxes & fees
28 Dec - 29 Dec
Quality Inn & Suites Santee I-95
Lobby
Red Roof Inn Santee

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (638)
"A good option if traveling with pets. The hotel is clean and well maintained but dated. "
United States
Karen
The price is ฿2,198
฿2,440 total
includes taxes & fees
23 Dec - 24 Dec
Red Roof Inn Santee
Exterior
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (678)
"The room was very nice. It was newly renovated and I loved the upgrade. The beds were comfortable and warm. We didn’t eat breakfast because we were meeting someone for breakfast. "
United States
Alice
The price is ฿1,916
฿2,127 total
includes taxes & fees
5 Jan - 6 Jan 2026
Travelodge by Wyndham Santee
Lobby
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (441)
"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "
United States
Kathy
The price is ฿2,356
฿2,615 total
includes taxes & fees
23 Dec - 24 Dec
Super 8 by Wyndham Santee
Property amenity
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.2 out of 10, (543)
"The grounds and property were clean and you could tell they take pride in what they're offering."
United States
Eric
The price is ฿2,498
฿2,773 total
includes taxes & fees
30 Dec - 31 Dec
Ramada by Wyndham Santee I-95
Front of property
Peach Tree Inn

Peach Tree Inn

Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (142)
"Clean rooms and pleasant staff. Could use newer towels. "
United States
Patricia
Peach Tree Inn
Free daily continental breakfast
Days Inn by Wyndham St George

Days Inn by Wyndham St George

Days Inn by Wyndham St George
2.5 star property
St. George
7.6 out of 10, Good, (1000)
"Helpful folks at check in and super clean room. "
United States
Peter
The price is ฿2,104
฿2,336 total
includes taxes & fees
11 Jan - 12 Jan 2026
Days Inn by Wyndham St George
Lobby
Tru by Hilton Orangeburg

Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1002)
"Wonderful stay"
United States
Josephine
The price is ฿3,322
฿3,688 total
includes taxes & fees
5 Jan - 6 Jan 2026
Tru by Hilton Orangeburg
Property amenity
SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg
2.5 star property
Orangeburg
9.0 out of 10, Wonderful, (673)
"The room was perfect and the staff was friendly and welcoming "
United States
Milton
The price is ฿3,289
฿3,651 total
includes taxes & fees
29 Dec - 30 Dec
SpringHill Suites by Marriott Orangeburg
Lobby
Econo Lodge St. George

Econo Lodge St. George

Econo Lodge St. George
2.0 star property
St. George
6.4 out of 10, (261)
"It was nice all together "
United States
Marcia
The price is ฿1,842
฿1,989 total
includes taxes & fees
15 Jan - 16 Jan 2026
Econo Lodge St. George
Cabin, 1 Bedroom, Non Smoking, Lake View | Private kitchen
Bells Marina & Resort

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (80)
"Room was clean with a beautiful view of the Lake."
United States
Melanie
Bells Marina & Resort
Lobby sitting area
Budget Inn By Belvilla St George I-95

Budget Inn By Belvilla St George I-95

Budget Inn By Belvilla St George I-95
2.5 star property
St. George
7.6 out of 10, Good, (155)
"This is a great value for a budget hotel. It's an older complex but clean and well maintained. It's close to decent food options for tired travelers and the front desk staff was pleasant and helpful. If you are looking for a convient, well priced stopover, I recommend this location. "
United States
Kim
The price is ฿2,037
฿2,450 total
includes taxes & fees
23 Dec - 24 Dec
Budget Inn By Belvilla St George I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santee attractions

Santee State Park

4.0/5 (112 reviews)
Perched on Lake Marion's shores, Santee State Park offers unique rondette cabins built over water. Hike through cypress swamps and sinkholes while spotting alligators, fox squirrels, and diverse birdlife.
See properties

Santee Cooper Country Club

3.9/5 (47 reviews)
This George Cobb-designed course winds through majestic pines with strategic doglegs and panoramic Lake Marion views. Enjoy the signature closing hole and well-maintained fairways perfect for golfers of all skill levels.
See properties

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

10/10 Excellent
"Great place and pet friendly. Rooms are clean and comfortable."
Penny 1-night trip
Posted 5 days ago
Spark by Hilton Orangeburg

More cheap stays in Santee

Baymont by Wyndham Orangeburg North

Baymont by Wyndham Orangeburg North

3583 Saint Matthews Rd Orangeburg SC
The price is ฿1,735 per night from 28 Dec to 29 Dec
฿1,735
฿1,926 total
28 Dec - 29 Dec
includes taxes & fees
5.8/10 (1,001 reviews)

Frequently asked questions

Where is the best place for a stay in Santee?
Hampton Inn Santee-I-95 is a favourite property for Expedia customers. This hotel offers free breakfast and free parking. Other top choices based on traveller reviews include Fairfield Inn & Suites by Marriott Santee and Tru By Hilton Santee. See all available top hotels, or vacation rentals in Santee.
What are some of the best holiday rentals that Santee has to offer?
Wyndham Vacation Resorts Lake Marion: This highly rated holiday home rental in Santee is equipped with an outdoor pool, free WiFi and cable TV to help you feel comfortable during your stay. Kitchen amenities include a full-sized fridge, a dishwasher and a stovetop. See all vacation rentals in Santee.
If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What's the best place to stay on a budget in Santee?
Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Santee.
What's the best family accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another good option for your stay with the kids. Find more child-friendly accommodations in Santee.
What is the top LGBTQ-friendly accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are two other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santee.
What's the best dog-friendly hotel in Santee?
Tru By Hilton Santee is a top dog-friendly hotel, and offers an indoor pool along with free WiFi for its human guests. Two other good options for you and your pet include Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee. See more pet-friendly hotel accommodations in Santee.
What's the best accommodation for a golf trip to Santee?
Holiday Inn Santee by IHG is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Ramada by Wyndham Santee I-95 and Super 8 by Wyndham Santee. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.
What are some accommodation options with pools in Santee?
Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast and free WiFi. Quality Inn & Suites Santee I-95 is an additional hotel with an on-site pool. View all hotels with pools in Santee.
What is staying in Santee like?
Families will find child-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and cafes. In Santee, there are 126 hotels and other accommodation options to choose from. Find out more about Santee.
What are the top places to visit in Santee?
Favourite places to visit include Santee Cooper Country Club, Santee State Park and Lake Marion. A couple of additional sights to add to your itinerary are Santee National Golf Club and Santee Town Hall. Take a look at what more there is to see and do in Expedia's Santee guide.
What's the seasonal weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.

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