Find hotels in Santa Cruz from ฿407

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Aug - 31 Aug
Tomorrow
31 Aug - 1 Sep
Next weekend
5 Sep - 7 Sep
In two weeks
12 Sep - 14 Sep

Filter by

Guest rating
Guest rating
Property class

Top 10 Santa Cruz hotels and places to stay

Mala Vecindad Centro Historico
Rooftop pool

Mala Vecindad Centro Historico

3.0 star property
8.8 out of 10, Excellent, (62)
"Friendly, supportive staff members. The place has a very unique decoration, as well as a rooftop with an impressive view of the city. It’s a quiet and relaxing place to rest but also to enjoy with family and friends."
Mala Vecindad Centro Historico
Verticca Hotel
Food and drink

Verticca Hotel

3.0 star property
9.4 out of 10, Exceptional, (183)
"Good place to stay "
Verticca Hotel
Hotel Madeira
Front of property

Hotel Madeira

3.5 star property
8.8 out of 10, Excellent, (163)
"Everything is okay "
The price is ฿1,225
฿1,470 total
includes taxes & fees
31 Aug - 1 Sept
Hotel Madeira
Hotel Finca Las Hortensias
Property grounds

Hotel Finca Las Hortensias

3.0 star property
8.2 out of 10, Very good, (179)
"Front desk service was excellent, the food was delicious and the service from Saul was wonderful. "
The price is ฿1,866
฿2,240 total
includes taxes & fees
31 Aug - 1 Sept
Hotel Finca Las Hortensias
Downtown Treasure Place
Business centre

Downtown Treasure Place

2.5 star property
8.8 out of 10, Excellent, (651)
"This ok, it's very nice, it's beautiful, "
The price is ฿1,372
฿1,660 total
includes taxes & fees
17 Sept - 18 Sept
Downtown Treasure Place
Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG
Bar (on property)

Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG

3.5 star property
9.4 out of 10, Exceptional, (816)
"The hotel is very well situated"
The price is ฿3,501
฿4,201 total
includes taxes & fees
5 Sept - 6 Sept
Holiday Inn Hotel and Suites Mexico Felipe Angeles Airport by IHG
Hotel Brasilia
Terrace/patio

Hotel Brasilia

3.0 star property
9.0 out of 10, Wonderful, (1007)
"It was a fantastic experience"
The price is ฿1,882
฿2,249 total
includes taxes & fees
31 Aug - 1 Sept
Hotel Brasilia
Hotel Coacalco
Front of property

Hotel Coacalco

2.5 star property
7.6 out of 10, Good, (60)
"Amazing room service"
The price is ฿841
฿975 total
includes taxes & fees
1 Sept - 2 Sept
Hotel Coacalco
Hotel La Rosa - Adults Only
Deluxe Room, 1 King Bed, Non Smoking | Blackout curtains, iron/ironing board, free WiFi, bed sheets

Hotel La Rosa - Adults Only

2.5 star property
8.2 out of 10, Very good, (414)
"Excelente "
Hotel La Rosa - Adults Only
Mala Vecindad Beer Hotel
Business centre

Mala Vecindad Beer Hotel

3.0 star property
8.0 out of 10, Very good, (197)
"A BEAUTIFUL hotel overall. Would repeat the stay."
Mala Vecindad Beer Hotel
Hotel Piet
Free self-parking

Hotel Piet

2.0 star property
7.4 out of 10, Good, (127)
"Nice hotel staff."
Hotel Piet
City Express by Marriott Ciudad de México La Villa
Lobby lounge

City Express by Marriott Ciudad de México La Villa

3.0 star property
8.8 out of 10, Excellent, (1009)
"Very clean place, the staff very friendly at all times. Very close to the basilica, would stay there again"
The price is ฿2,194
฿2,621 total
includes taxes & fees
6 Sept - 7 Sept
City Express by Marriott Ciudad de México La Villa
Autoparador del Valle
Reception

Autoparador del Valle

3.0 star property
7.2 out of 10, Good, (5)
"Affordable nice room"
Autoparador del Valle
Lamartine Boutique Hotel Polanco
Superior Studio Suite, 1 King Bed, Balcony | Balcony

Lamartine Boutique Hotel Polanco

5.0 star property
10.0 out of 10, Exceptional, (14)
"Fantastic place. Beautiful, reasonable price and helpful staff."
The price is ฿7,799
฿9,320 total
includes taxes & fees
28 Sept - 29 Sept
Lamartine Boutique Hotel Polanco
Edgar Allan Poe 227 By Ömora
Exclusive Apartment, 1 Bedroom, Patio | Terrace/patio

Edgar Allan Poe 227 By Ömora

3.5 star property
10.0 out of 10, Exceptional, (23)
"Will definitely stay here again. Can’t say one bad thing about this place. "
The price is ฿2,839
฿3,393 total
includes taxes & fees
1 Sept - 2 Sept
Edgar Allan Poe 227 By Ömora
RHM Spaces - Santa Maria
Single Room | 1 bedroom, free WiFi

RHM Spaces - Santa Maria

2.0 star property
7.0 out of 10, Good, (57)
"Convenient place for 1-2 person stay"
The price is ฿407
฿486 total
includes taxes & fees
31 Aug - 1 Sept
RHM Spaces - Santa Maria
Gran Hotel Panorama
Interior entrance

Gran Hotel Panorama

3.0 star property
8.4 out of 10, Very good, (970)
"Friendly staff "
The price is ฿666
฿796 total
includes taxes & fees
31 Aug - 1 Sept
Gran Hotel Panorama
KALI La Raza Mexico City
Breakfast buffet

KALI La Raza Mexico City

2.5 star property
9.4 out of 10, Exceptional, (164)
"Great place to stay"
KALI La Raza Mexico City
Collection O Casa Anzures Thematic, Mexico City
Deluxe Studio, 1 Bedroom | Balcony

Collection O Casa Anzures Thematic, Mexico City

3.0 star property
8.8 out of 10, Excellent, (115)
"A creative and unique space."
The price is ฿1,496
฿1,863 total
includes taxes & fees
17 Sept - 18 Sept
Collection O Casa Anzures Thematic, Mexico City
UTOPIC Polanco by ULIV
Standard Double Suite | City view

UTOPIC Polanco by ULIV

4.5 star property
9.0 out of 10, Wonderful, (618)
"It’s a good place to stay, specially if going for business purposes"
UTOPIC Polanco by ULIV
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

More cheap stays in Santa Cruz

Casa Olea

Casa Olea

C. de Francisco Díaz Covarrubias, 76, Mexico City, CDMX
The price is ฿1,999 per night from 3 Sept to 4 Sept
฿1,999
฿2,389 total
3 Sept - 4 Sept
includes taxes & fees
9.4/10 Exceptional! (450 reviews)

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place for a stay in Santa Cruz?

Located 18.9 mi (30.5 km) from the heart of Santa Cruz, Hyatt Regency Mexico City is a top choice for your stay, based on our traveller data. Two other choices for your stay in the area are InterContinental Presidente Mexico City by IHG and Casa Olea. See all available top hotels, or vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

What is staying in Santa Cruz like?

Those travelling to Santa Cruz will definitely enjoy the sights to see and things to do. There are 1817 hotels and other accommodation options in the surrounding area. Find out more about Santa Cruz.

What are the top places to visit in Santa Cruz?

Places to visit in the wider area include Hacienda La Concepcion, National Museum of the Viceroyalty and San Marcos Power Center. You'll also find Xochitla Ecological Park and Arcos del Sitio in the area. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.

What's the seasonal weather like in Santa Cruz?

The hottest months are usually April and May, with an average temperature of 18°C, while the coldest months are January and December, with an average of 14°C. The rainiest months in Santa Cruz are August, July, September and June, with each month seeing an average of 186 mm of rainfall.