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Check prices for these dates

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27 Dec - 28 Dec
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28 Dec - 29 Dec
Next weekend
2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

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Our top choices for Santa Cruz de la Sierra hotels

Lobby
Hospedium Hotel Soterraña

Hospedium Hotel Soterraña

Hospedium Hotel Soterraña
3.0 star property
Madronera
8.8 out of 10, Excellent, (37)
This colonial hotel offers relaxation in Madronera with 2 bars and 2 restaurants for dining options. Enjoy the outdoor terrace and garden after a day of exploring, plus convenient amenities like free WiFi and parking.
"Kostenloser Parkplatz und Sauberkeit sind positiv hervorzuheben. Der Ort bietet so gut eie nichts. Wir waren im Nebengebäude untergebracht. Man kommt sich abgeschoben vor, weil es Personal und Frühstück nur im Haupthaus auf der anderen Straßenseite gibt. Das Zimmer war sehr dunkel (dunkle Einrichtung, kleines Fenster, unzureichendes Lampenlicht). Abendessen gibt es erst ab 20.00 Uhr. "
Germany
Bärbel
The price is ฿2,292
฿2,521 total
includes taxes & fees
29 Dec - 30 Dec
Hospedium Hotel Soterraña
Front of property
Finca la Desa

Finca la Desa

Finca la Desa
3.0 star property
Miajadas
9.6 out of 10, Exceptional, (5)
"Buenas situación , personal amable y buena comida"
Spain
José Jesús
The price is ฿2,524
฿2,777 total
includes taxes & fees
28 Dec - 29 Dec
Finca la Desa
Outdoor pool
Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (327)
Set in historic Trujillo, this 16th-century palace hotel offers an outdoor pool where guests can relax after sightseeing. The restaurant serves delicious meals, and the bar provides refreshing drinks. Plaza Mayor and Francisco Pizarro's statue are located nearby.
"Just excellent, Service from all staff is perfect "
Mexico
Jor
The price is ฿1,943
฿2,137 total
includes taxes & fees
26 Jan - 27 Jan 2026
Eurostars Palacio Santa Marta
Hallway
Parador de Trujillo

Parador de Trujillo

Parador de Trujillo
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (224)
Escape to a historic haven with garden terrace and café near Palace of the Dukes of San Carlos. This former monastery offers refreshing swims, drinks at the bar, and easy access to Pizarro's statue in charming Trujillo.
"Very nice hotel, good parking, well located, "
United States
Edgar
The price is ฿2,654
฿2,919 total
includes taxes & fees
8 Jan - 9 Jan 2026
Parador de Trujillo
Breakfast, lunch, dinner served; Regional cuisine
Hostal Hueso

Hostal Hueso

Hostal Hueso
2.0 star property
Trujillo
8.2 out of 10, Very good, (23)
Discover historic charm near Juan Pizarro de Orellana Palace and Palacio de la Conquista. This hostal offers room service and a restaurant where you can savour local flavours after exploring Trujillo's ancient streets.
"Excelent location, excelent staf"
United States
ALFRED
The price is ฿1,997
฿2,197 total
includes taxes & fees
28 Dec - 29 Dec
Hostal Hueso
Interior
Plaza Sandra

Plaza Sandra

Plaza Sandra
3.0 star property
Trujillo
9.6 out of 10, Exceptional, (51)
This peaceful aparthotel features kitchenettes and sofa beds in spacious apartments. Take a refreshing dip in the outdoor pool, enjoy garden views from the terrace, or book a rejuvenating massage—all just minutes from historic Trujillo attractions.
"Good staff and beautiful place "
United States
Juan
Plaza Sandra
Interior
Hotel Izan Trujillo

Hotel Izan Trujillo

Hotel Izan Trujillo
4.0 star property
Trujillo
8.8 out of 10, Excellent, (209)
Experience the charm of Spain at this hotel with a seasonal outdoor pool and terrace. El Refectorio restaurant serves delicious regional cuisine, while the bar offers refreshing drinks. Near Museo de Vino y Queso and just steps from historic palaces.
"We enjoyed our stay, albeit just for one night. Nice hotel. Totally recommend. "
United Kingdom
Younes
The price is ฿2,255
฿2,480 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Izan Trujillo
Property grounds
Hostal León

Hostal León

Hostal León
2.0 star property
Trujillo
7.6 out of 10, Good, (52)
Located near Museo de Vino y Queso and Palace of the Dukes of San Carlos, this cosy hostal offers free WiFi and daily housekeeping. Enjoy convenient access to Trujillo's historic attractions during your authentic Spanish getaway.
"Bien "
Spain
Antonio Manuel
The price is ฿1,827
฿2,009 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hostal León
Food court
Casa Rural Las Canteras

Casa Rural Las Canteras

Casa Rural Las Canteras
3.0 star property
Trujillo
8.2 out of 10, Very good, (33)
Set in Trujillo, this rural retreat offers a peaceful garden and terrace for relaxation. The on-site restaurant serves authentic dishes, while the bar provides refreshing drinks. Just minutes from Trujillo Castle and Pizarro House Museum.
"Limpieza correcta "
Spain
Carlos
The price is ฿2,956
฿3,251 total
includes taxes & fees
28 Dec - 29 Dec
Casa Rural Las Canteras
Coffee shop
Hospedium Hotel Triana

Hospedium Hotel Triana

Hospedium Hotel Triana
3.0 star property
Miajadas
7.8 out of 10, Good, (19)
Escape to this welcoming retreat featuring a restaurant, bar, and convenient deli. Free WiFi and parking enhance your stay while exploring Miajadas, just a short drive from Don Benito Station.
"This is a very convenient stop-over between Santander and Barbate/Vejer/Conil where we were staying. Simple, clean room,super helpful staff and great food at an amazing price. Free car parking in a plot next to the hotel. We've stayed here before and will do so again."
United Kingdom
tina
The price is ฿2,790
฿3,069 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hospedium Hotel Triana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz de la Sierra Hotel Reviews

Finca El Azahar

Finca El Azahar

10/10 Excellent
"Stunning, warm, beautiful, "
Alex 1-night trip
Posted 7 months ago
Finca El Azahar

More cheap stays in Santa Cruz de la Sierra

Hostal León

Hostal León

Campillo 11 Trujillo Caceres
The price is ฿1,827 per night from 4 Jan to 5 Jan
฿1,827
฿2,009 total
4 Jan - 5 Jan 2026
includes taxes & fees
7.6/10 Good! (51 reviews)

Frequently asked questions

What's the best place to stay in Santa Cruz de la Sierra?
Parador de Trujillo, located 0.1 mi (0.1 km) from the heart of Santa Cruz de la Sierra, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Eurostars Palacio Santa Marta and Hotel Izan Trujillo. See all available top hotels, or vacation rentals in Santa Cruz de la Sierra.
If I need to cancel my hotel reservation in Santa Cruz de la Sierra, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz de la Sierra.
What are some accommodation options with pools in Santa Cruz de la Sierra?
Parador de Trujillo: Offers a snack bar/deli, a seasonal outdoor pool and complimentary high-speed (wired) Internet access. View all hotels with pools in Santa Cruz de la Sierra.
How is it staying in Santa Cruz de la Sierra?
Those travelling to Santa Cruz de la Sierra will definitely enjoy the sights to see and things to do. In Santa Cruz de la Sierra, there are 9 hotels and other accommodation options to choose from. Find out more about Santa Cruz de la Sierra.
What should I do while I'm visiting Santa Cruz de la Sierra?
Places to visit in the wider area include Juan Pizarro de Orellana Palace, City Walls and Plaza Mayor. You'll also find Trujillo Castle and Museo de Vino y Queso in the area. Take a look at what more there is to see and do in Expedia's Santa Cruz de la Sierra guide.
What's the seasonal weather in Santa Cruz de la Sierra?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 9°C. Average annual precipitation for Santa Cruz de la Sierra is 571 mm.